PMID- 35844687
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220719
IS  - 2688-6146 (Electronic)
IS  - 2688-6146 (Linking)
VI  - 2
IP  - 3
DP  - 2021 Aug
TI  - Bleeding is associated with intravenous immunoglobulin and therapeutic plasma 
      exchange use in heparin-induced thrombocytopenia: A propensity matched analysis.
PG  - 466-470
LID - 10.1002/jha2.211 [doi]
AB  - Intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE) are used 
      in select cases with heparin-induced thrombocytopenia (HIT). In a cross-sectional 
      analysis, a propensity matched sample was generated by IVIG or TPE treatment 
      status to assess the primary outcome of mortality. In 500 HIT cases, IVIG or TPE 
      was not associated with increased mortality (OR = 1.46; 95% CI: 0.81-2.63, 
      p = 0.2052) but was associated with a higher likelihood of major bleeding 
      (OR = 1.75; 95% CI: 1.03-2.96, p = 0.0376). The use of IVIG or TPE in HIT cases 
      with bleeding contraindications to standard therapies should be further 
      investigated.
CI  - (c) 2021 The Authors. eJHaem published by British Society for Haematology and John 
      Wiley & Sons Ltd.
FAU - Soares Ferreira Junior, Alexandre
AU  - Soares Ferreira Junior A
AD  - School of Medicine Barretos School of Health Sciences Dr. Paulo Prata Barretos 
      Sao Paulo Brazil.
AD  - Department of Medicine Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP) 
      Sao Jose do Rio Preto Sao Paulo Brazil.
FAU - Boyle, Stephen H
AU  - Boyle SH
AD  - Duke University School of Medicine Durham North Carolina USA.
FAU - Kuchibhatla, Maragatha
AU  - Kuchibhatla M
AD  - Department of Biostatistics and Bioinformatics Duke University School of Medicine 
      Durham North Carolina USA.
FAU - Onwuemene, Oluwatoyosi A
AU  - Onwuemene OA
AUID- ORCID: 0000-0001-7266-7101
AD  - Division of Hematology Department of Medicine Duke University School of Medicine 
      Durham North Carolina USA.
LA  - eng
PT  - Journal Article
DEP - 20210507
PL  - United States
TA  - EJHaem
JT  - EJHaem
JID - 101761942
PMC - PMC9175867
OTO - NOTNLM
OT  - National Inpatient Sample
OT  - heparin-induced thrombocytopenia
OT  - intravenous immune globulin
OT  - therapeutic plasma exchange
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/07 00:00
MHDA- 2021/05/07 00:01
PMCR- 2021/05/07
CRDT- 2022/07/18 03:40
PHST- 2021/03/30 00:00 [received]
PHST- 2021/04/14 00:00 [revised]
PHST- 2021/04/20 00:00 [accepted]
PHST- 2022/07/18 03:40 [entrez]
PHST- 2021/05/07 00:00 [pubmed]
PHST- 2021/05/07 00:01 [medline]
PHST- 2021/05/07 00:00 [pmc-release]
AID - JHA2211 [pii]
AID - 10.1002/jha2.211 [doi]
PST - epublish
SO  - EJHaem. 2021 May 7;2(3):466-470. doi: 10.1002/jha2.211. eCollection 2021 Aug.