PMID- 35844729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220719
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 10
DP  - 2022
TI  - The Effect of Vitamin D Supplementation in Children With Asthma: A Meta-Analysis.
PG  - 840617
LID - 10.3389/fped.2022.840617 [doi]
LID - 840617
AB  - BACKGROUND: An increasing number of studies have suggested that vitamin D can be 
      used to treat childhood asthma, but its clinical effects are still unclear. We 
      conducted this meta-analysis to examine the latest estimates of the effectiveness 
      and safety of using vitamin D to treat childhood asthma. METHODS: The PubMed, The 
      Cochrane Library, ScienceDirect, Embase, Scopus, Ovid MEDLINE, Web of Science, 
      and Google Scholar databases were searched for randomized controlled trials 
      (RCTs) describing vitamin D supplementation interventions for asthmatic children. 
      Asthma exacerbation, vitamin D levels, the predicted percentage of forced 
      expiratory volume in the first second (FEV1%) and adverse effects (AEs) were 
      analyzed as the main outcome measures. RESULTS: After screening, eight RCTs with 
      738 children were included. Compared with placebos, vitamin D supplementation had 
      a stronger effect on serum vitamin D levels [mean difference (MD) = 13.51 (4.24, 
      22.79), p = 0.004]. The pooled results indicated that no significant changes were 
      found between the groups in asthma control, as measured by adopting the following 
      indicators: asthma exacerbation [risk ratio (RR) = 0.92 (0.68, 1.25), p = 0.60]; 
      Childhood Asthma Control Test (CACT) scores [MD = 0.15 (-0.43, 0.74), p = 0.61]; 
      hospitalizations for asthma exacerbation [RR = 1.20 (0.48, 2.96), p = 0.70]; 
      acute care visits [RR = 1.13 (0.77, 1.65), p = 0.63]; steroid use [RR = 1.03 
      (0.41, 2.57), p = 0.95]; and fractional exhaled nitric oxide (FeNO) [MD =-3.95 
      (-22.87, 14.97), p = 0.68]. However, vitamin D supplementation might reduce the 
      FEV1% [MD = -4.77 (-9.35, -0.19), p = 0.04] and the percentage of predicted 
      forced vital capacity (FVC%) [MD =-5.01 (-9.99, -0.02), p = 0.05] in patients. 
      Subgroup analysis revealed no difference in AEs between the two groups. 
      CONCLUSIONS: Vitamin D supplementation significantly increased patients' serum 
      vitamin D levels, but it had no benefit for asthma control. However, vitamin D 
      supplementation might reduce patients' lung function. It is essential to 
      systemically search for more large-scale, rigorous, and well-designed RCTs to 
      fully confirm these conclusions. SYSTEMATIC REVIEW REGISTRATION: 
      https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021288838, 
      PROSPERO CRD42021288838.
CI  - Copyright (c) 2022 Hao, Xu, Luo, Liu, Xie and Zhang.
FAU - Hao, Meiqi
AU  - Hao M
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
AD  - Jiangxi Medical College, Nanchang University, Nanchang, China.
FAU - Xu, Ruoxin
AU  - Xu R
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
AD  - Jiangxi Medical College, Nanchang University, Nanchang, China.
FAU - Luo, Nachuan
AU  - Luo N
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
AD  - Jiangxi Medical College, Nanchang University, Nanchang, China.
FAU - Liu, Miaowen
AU  - Liu M
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
AD  - Jiangxi Medical College, Nanchang University, Nanchang, China.
FAU - Xie, Junping
AU  - Xie J
AD  - Department of Respiratory and Critical Care Medicine, The Second Affiliated 
      Hospital of Nanchang University, Nanchang, China.
FAU - Zhang, Wenxiong
AU  - Zhang W
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
LA  - eng
PT  - Systematic Review
DEP - 20220629
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC9277022
OTO - NOTNLM
OT  - asthma
OT  - children
OT  - meta-analysis
OT  - systematic review
OT  - vitamin D
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/19 06:00
MHDA- 2022/07/19 06:01
PMCR- 2022/06/29
CRDT- 2022/07/18 03:40
PHST- 2021/12/21 00:00 [received]
PHST- 2022/06/03 00:00 [accepted]
PHST- 2022/07/18 03:40 [entrez]
PHST- 2022/07/19 06:00 [pubmed]
PHST- 2022/07/19 06:01 [medline]
PHST- 2022/06/29 00:00 [pmc-release]
AID - 10.3389/fped.2022.840617 [doi]
PST - epublish
SO  - Front Pediatr. 2022 Jun 29;10:840617. doi: 10.3389/fped.2022.840617. eCollection 
      2022.