PMID- 35845001
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230916
IS  - 2688-6146 (Electronic)
IS  - 2688-6146 (Linking)
VI  - 1
IP  - 2
DP  - 2020 Nov
TI  - Improvement in progressive multifocal leukoencephalopathy after 
      pembrolizumab-induced immune reconstruction inflammatory syndrome in a patient 
      with follicular lymphoma.
PG  - 585-588
LID - 10.1002/jha2.56 [doi]
AB  - Progressive multifocal leukoencephalopathy (PML) may develop in follicular 
      lymphoma patients treated with bendamustine-rituximab. In this report, treatment 
      with pembrolizumab successfully inhibited the clinical progression of PML by 
      promoting radiologically demonstrated immune restoration inflammatory syndrome 
      (IRIS), allowing complete clearance of the virus. These findings may further 
      support the use of pembrolizumab in PML with special consideration for the 
      potential occurrence of IRIS.
CI  - (c) 2020 The Authors. eJHaem published by British Society for Haematology and John 
      Wiley & Sons Ltd.
FAU - Dufour, Ines
AU  - Dufour I
AD  - Department of Hematology Universite catholique de Louvain, Cliniques 
      universitaires Saint-Luc Brussels Belgium.
FAU - Duprez, Thierry
AU  - Duprez T
AD  - Department of Radiology and Medical Imaging Universite catholique de Louvain, 
      Cliniques universitaires Saint-Luc Brussels Belgium.
FAU - Wertz, Marie
AU  - Wertz M
AD  - Department of Neurology Clinique Notre-Dame de Grace Gosselies Belgium.
FAU - Saussoy, Pascale
AU  - Saussoy P
AD  - Hematology Laboratory Universite catholique de Louvain, Cliniques universitaires 
      Saint-Luc Brussels Belgium.
FAU - Ackermans, Nathalie
AU  - Ackermans N
AD  - Department of Neurology Universite catholique de Louvain, Cliniques 
      universitaires Saint-Luc Brussels Belgium.
FAU - El Sankari, Souraya
AU  - El Sankari S
AD  - Department of Neurology Universite catholique de Louvain, Cliniques 
      universitaires Saint-Luc Brussels Belgium.
FAU - van Pesch, Vincent
AU  - van Pesch V
AD  - Department of Neurology Universite catholique de Louvain, Cliniques 
      universitaires Saint-Luc Brussels Belgium.
FAU - Van Den Neste, Eric
AU  - Van Den Neste E
AUID- ORCID: 0000-0002-7846-4185
AD  - Department of Hematology Universite catholique de Louvain, Cliniques 
      universitaires Saint-Luc Brussels Belgium.
LA  - eng
PT  - Case Reports
DEP - 20201023
PL  - United States
TA  - EJHaem
JT  - EJHaem
JID - 101761942
PMC - PMC9175693
OTO - NOTNLM
OT  - Follicular lymphoma
OT  - JC virus
OT  - immune reconstruction inflammatory syndrome
OT  - pembrolizumab
OT  - progressive multifocal leukoencephalopathy
COIS- The authors declare no conflict of interest.Ines Dufour, Eric Van Den Neste, 
      Thierry Duprez, Marie Wertz, Pascale Saussoy, Nathalie Ackermans, Souraya El 
      Sankari, and Vincent van Pesch contributed to patient management, data 
      collection, and revised the paper. Ines Dufour and Eric Van Den Neste wrote the 
      paper.
EDAT- 2020/10/23 00:00
MHDA- 2020/10/23 00:01
PMCR- 2020/10/23
CRDT- 2022/07/18 03:44
PHST- 2020/06/15 00:00 [received]
PHST- 2020/06/23 00:00 [revised]
PHST- 2020/06/24 00:00 [accepted]
PHST- 2022/07/18 03:44 [entrez]
PHST- 2020/10/23 00:00 [pubmed]
PHST- 2020/10/23 00:01 [medline]
PHST- 2020/10/23 00:00 [pmc-release]
AID - JHA256 [pii]
AID - 10.1002/jha2.56 [doi]
PST - epublish
SO  - EJHaem. 2020 Oct 23;1(2):585-588. doi: 10.1002/jha2.56. eCollection 2020 Nov.