PMID- 35846201
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220719
IS  - 2688-6146 (Electronic)
IS  - 2688-6146 (Linking)
VI  - 3
IP  - 1
DP  - 2022 Feb
TI  - Redefining the high-grade B cell lymphoma with double/triple rearrangements of 
      MYC and BCL2/BCL6 genes. Learning from a case report.
PG  - 171-174
LID - 10.1002/jha2.310 [doi]
AB  - We report a patient initially diagnosed with a triple hit high-grade B cell 
      lymphoma (HGBL-TH), in which further morphologic, immunohistochemical, and 
      next-generation sequencing studies of subsequent specimens disclosed it to be a 
      germinal center diffuse large B cell lymphoma (GC-DLBCL) with BCL2/BCL6 gene 
      translocations, PVT1-deletion, and gain of MYC genes evolving from a previous 
      follicular lymphoma. However, fluorescence in situ hybridization (FISH) studies 
      with the break-apart probe for MYC gene showed a fusion and two separated signals 
      (red and green, respectively) leading to the interpretation of MYC gene 
      translocation and a false diagnosis of a TH-lymphoma, according to the recent WHO 
      classification. Nevertheless, PVT1 deletion plus MYC gain/amplification has been 
      described as a cause of the double-hi transcription profile. These data highlight 
      the need for new criteria to identify these highly aggressive lymphomas.
CI  - (c) 2021 The Authors. eJHaem published by British Society for Haematology and John 
      Wiley & Sons Ltd.
FAU - Rodriguez-Pinilla, Socorro Maria
AU  - Rodriguez-Pinilla SM
AUID- ORCID: 0000-0002-2191-1327
AD  - Pathology Department Hospital Universitario Fundacion Jimenez Diaz (FJD) Madrid 
      Spain.
FAU - Salgado, Rocio Nieves
AU  - Salgado RN
AD  - Cytogenetic Department Hospital Universitario Fundacion Jimenez Diaz (FJD) Madrid 
      Spain.
FAU - Chamizo, Cristina
AU  - Chamizo C
AD  - Pathology Department Hospital Universitario Fundacion Jimenez Diaz (FJD) Madrid 
      Spain.
FAU - Santonja, Carlos
AU  - Santonja C
AD  - Pathology Department Hospital Universitario Fundacion Jimenez Diaz (FJD) Madrid 
      Spain.
FAU - Stewart, Peter
AU  - Stewart P
AD  - Patrick G Johnston Centre for Cancer Research Queen's University Belfast Belfast 
      UK.
FAU - Carvajal, Nerea
AU  - Carvajal N
AD  - Pathology Department Hospital Universitario Fundacion Jimenez Diaz (FJD) Madrid 
      Spain.
FAU - McCafferty, Neil
AU  - McCafferty N
AD  - Patrick G Johnston Centre for Cancer Research Queen's University Belfast Belfast 
      UK.
FAU - Manso, Rebeca
AU  - Manso R
AD  - Pathology Department Hospital Universitario Fundacion Jimenez Diaz (FJD) Madrid 
      Spain.
FAU - Morillo, Daniel
AU  - Morillo D
AD  - Haematology Department Hospital Universitario Fundacion Jimenez Diaz Madrid 
      Spain.
FAU - Piris, Miguel Angel
AU  - Piris MA
AD  - Pathology Department Hospital Universitario Fundacion Jimenez Diaz (FJD) Madrid 
      Spain.
FAU - Gonzalez de Castro, David
AU  - Gonzalez de Castro D
AD  - Patrick G Johnston Centre for Cancer Research Queen's University Belfast Belfast 
      UK.
LA  - eng
PT  - Journal Article
DEP - 20211109
PL  - United States
TA  - EJHaem
JT  - EJHaem
JID - 101761942
PMC - PMC9175839
OTO - NOTNLM
OT  - B-cell lymphomas with double or triple hits
OT  - MYC
OT  - PVT1
OT  - fluorescence in situ hybridization
OT  - follicular lymphoma
COIS- Dr. Piris is sponsored by TAKEDA. The other authors have no conflicts to declare.
EDAT- 2022/07/19 06:00
MHDA- 2022/07/19 06:01
PMCR- 2021/11/09
CRDT- 2022/07/18 03:59
PHST- 2021/06/28 00:00 [received]
PHST- 2021/09/14 00:00 [revised]
PHST- 2021/09/20 00:00 [accepted]
PHST- 2022/07/18 03:59 [entrez]
PHST- 2022/07/19 06:00 [pubmed]
PHST- 2022/07/19 06:01 [medline]
PHST- 2021/11/09 00:00 [pmc-release]
AID - JHA2310 [pii]
AID - 10.1002/jha2.310 [doi]
PST - epublish
SO  - EJHaem. 2021 Nov 9;3(1):171-174. doi: 10.1002/jha2.310. eCollection 2022 Feb.