PMID- 35846303
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220802
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Association of Serum 25 (OH) Vitamin D With Chronic Kidney Disease Progression in 
      Type 2 Diabetes.
PG  - 929598
LID - 10.3389/fendo.2022.929598 [doi]
LID - 929598
AB  - OBJECTIVES: Growing evidence demonstrated that vitamin D levels had been linked 
      to type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) in light of 
      various extraskeletal effects. Therefore, the present study aimed to evaluate the 
      association of 25-hydroxyvitamin D [25(OH)D] level with the clinicopathological 
      features and CKD progression in T2DM. METHODS: A total of 182 patients with T2DM 
      with CKD stages 1 through 4 (G1-G4) were retrospectively included. Identification 
      of the serum 25(OH)D level associated with CKD progression was executed by 
      Kaplan-Meier survival analysis and Cox proportional hazards models. We further 
      performed sensitivity analyses with a time-weighted average (TWA) of the serum 
      25(OH)D level in 75 participants to reinforce the findings. RESULTS: The median 
      serum 25(OH)D level was 26 (IQR, 14; 39) nmol/L in the study participants. Median 
      follow-up time was 42 months, during which 70 (38%) patients confronted CKD 
      progression. Cumulative kidney outcomes were significantly higher in the lowest 
      tertile of the serum 25(OH)D level in Kaplan-Meier analyses (P < 0.001). 
      Consistently, the analyses of Cox proportional hazards regression models 
      indicated a significantly greater risk for CKD progression in the lowest tertile 
      of the serum 25(OH)D level compared with the highest tertile of the serum 25(OH)D 
      level (P = 0.03). These relationships remained robust with further sensitivity 
      analysis of data with TWA of the serum 25(OH)D level, showing an independent 
      association between lower TWA of the serum 25(OH)D level and an unfavorable renal 
      outcome in patients with T2DM with CKD. CONCLUSIONS: Our findings demonstrated 
      that patients with T2DM with a decreased 25(OH)D level had deteriorated renal 
      function. Both lower levels of baseline and TWA of serum 25(OH)D were associated 
      with an increased risk of CKD progression in patients with T2DM, which suggested 
      that the long-term maintenance of optimal vitamin D levels from early in life 
      might be associated with reduced future risk of CKD development in T2DM.
CI  - Copyright (c) 2022 Duan, Lu, Wu, Zhang, Nie, Sun, Huang, Guo, Zhang, Xing and Yuan.
FAU - Duan, Suyan
AU  - Duan S
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Lu, Fang
AU  - Lu F
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Wu, Buyun
AU  - Wu B
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Zhang, Chengning
AU  - Zhang C
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Nie, Guangyan
AU  - Nie G
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Sun, Lianqin
AU  - Sun L
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Huang, Zhimin
AU  - Huang Z
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Guo, Honglei
AU  - Guo H
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Zhang, Bo
AU  - Zhang B
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Xing, Changying
AU  - Xing C
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
FAU - Yuan, Yanggang
AU  - Yuan Y
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220630
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Vitamins)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - *Renal Insufficiency, Chronic/complications
MH  - Retrospective Studies
MH  - Vitamin D
MH  - *Vitamin D Deficiency/complications
MH  - Vitamins
PMC - PMC9279917
OTO - NOTNLM
OT  - 25-hydroxyvitamin D
OT  - CKD progression
OT  - diabetic kidney disease
OT  - non-diabetic kidney disease
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/19 06:00
MHDA- 2022/07/20 06:00
PMCR- 2022/01/01
CRDT- 2022/07/18 04:00
PHST- 2022/04/27 00:00 [received]
PHST- 2022/05/30 00:00 [accepted]
PHST- 2022/07/18 04:00 [entrez]
PHST- 2022/07/19 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.929598 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jun 30;13:929598. doi: 
      10.3389/fendo.2022.929598. eCollection 2022.