PMID- 35846493
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220719
IS  - 1394-195X (Print)
IS  - 2180-4303 (Electronic)
IS  - 1394-195X (Linking)
VI  - 29
IP  - 3
DP  - 2022 Jun
TI  - The Effect of PRKAA2 Variation on Type 2 Diabetes Mellitus in the Asian 
      Population: A Systematic Review and Meta-Analysis.
PG  - 5-16
LID - 10.21315/mjms2022.29.3.2 [doi]
AB  - The prevalence of type 2 diabetes mellitus (T2DM) is increasing among Asians. The 
      adenosine monophosphate-activated protein kinase (AMPK) increases T2DM risk 
      through insulin resistance. Glucose levels are related to AMPK subunit alpha2 encoded 
      by PRKAA2. This systematic review and meta-analysis aimed to analyse the 
      association between PRKAA2 variation and T2DM risk. Publication search related to 
      PRKAA2 and T2DM used PubMed, ProQuest, and ScienceDirect databases. Article 
      selection based on inclusion and exclusion criteria only included Japanese and 
      Chinese populations. This meta-analysis used five genotype models to estimate the 
      effect of PRKAA2 variation and T2DM risk. Additionally, a fixed-effect model was 
      selected to measure the pooled size effect if P > 0.05 or I(2) < 50%. Qualitative 
      analysis included four eligible studies, and meta-analysis included only two 
      studies because both showed data concerning rs2746342 variation. Patients with G 
      allele are 1.45 times more likely to have T2DM than patients with T allele (95% 
      confidence interval [CI]: 1.20, 1.76; P: 0.0001). Notably, patients who had GG 
      genotype have 1.96 times higher risk of T2DM compared with those with TT genotype 
      (95% CI: 1.34, 2.87; P: 0.0005), dominant model (odds ratio [OR]: 1.75; 95% CI: 
      1.32, 2.31; P: 0.001), and recessive model (OR: 1.43; 95% CI: 1.01, 2.01; P: 
      0.04). PRKAA2 variation, especially in rs2746342, has an association with T2DM 
      risk in the G allele, additive, dominant, and recessive models. G allele might be 
      the most contributable factor in increasing T2DM susceptibility.
CI  - (c) Penerbit Universiti Sains Malaysia, 2022.
FAU - Virginia, Dita Maria
AU  - Virginia DM
AD  - Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, 
      Yogyakarta, Indonesia.
AD  - Faculty of Pharmacy, Sanata Dharma University, Yogyakarta, Indonesia.
FAU - Dwiprahasto, Iwan
AU  - Dwiprahasto I
AD  - Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, 
      Yogyakarta, Indonesia.
FAU - Wahyuningsih, Mae Sri Hartati
AU  - Wahyuningsih MSH
AD  - Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, 
      Yogyakarta, Indonesia.
FAU - Nugrahaningsih, Dwi Aris Agung
AU  - Nugrahaningsih DAA
AD  - Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, 
      Yogyakarta, Indonesia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220628
PL  - Malaysia
TA  - Malays J Med Sci
JT  - The Malaysian journal of medical sciences : MJMS
JID - 101126308
PMC - PMC9249426
OTO - NOTNLM
OT  - AMP-activated protein kinase
OT  - Asian
OT  - genetic variation
OT  - risk factor
OT  - type 2 diabetes mellitus
COIS- Conflict of Interest None.
EDAT- 2022/07/19 06:00
MHDA- 2022/07/19 06:01
PMCR- 2022/06/01
CRDT- 2022/07/18 04:03
PHST- 2020/06/12 00:00 [received]
PHST- 2021/07/16 00:00 [accepted]
PHST- 2022/07/18 04:03 [entrez]
PHST- 2022/07/19 06:00 [pubmed]
PHST- 2022/07/19 06:01 [medline]
PHST- 2022/06/01 00:00 [pmc-release]
AID - 02mjms2903_ra [pii]
AID - 10.21315/mjms2022.29.3.2 [doi]
PST - ppublish
SO  - Malays J Med Sci. 2022 Jun;29(3):5-16. doi: 10.21315/mjms2022.29.3.2. Epub 2022 
      Jun 28.