PMID- 35846982
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220719
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2022
DP  - 2022
TI  - Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A 
      Potential Link with Disease Severity.
PG  - 5395248
LID - 10.1155/2022/5395248 [doi]
LID - 5395248
AB  - A growing number of studies indicate the potential involvement of various 
      populations of bone marrow-derived stem cells (BMSCs) in tissue repair. However, 
      the mobilization of BMSCs to the peripheral blood (PB) in acute and chronic 
      pancreatitis (AP and CP) has not been investigated. A total of 78 patients were 
      assigned into AP, CP, and healthy control groups in this study. Using flow 
      cytometry, we found that VSELs, EPCs, and CD133(+)SCs were mobilized to the PB of 
      patients with both AP and CP. Interestingly, AP and CP patients exhibited lower 
      absolute number of circulating MSCs in the PB compared to healthy individuals. SC 
      mobilization to the PB was more evident in patients with AP than CP and in 
      patients with moderate/severe AP than mild AP. Using ELISA, we found a 
      significantly increased HGF concentration in the PB of patients with AP and SDF1alpha 
      in the PB of patients with CP. We noted a significant positive correlation 
      between SDF1alpha concentration and the mobilized population of CD133(+)SCs in AP and 
      between C5a and the mobilized population of VSELs moderate/severe AP. Thus, bone 
      marrow-derived SCs may play a role in the regeneration of pancreatic tissue in 
      both AP and CP, and mobilization of VSELs to the PB depends on the severity of 
      AP.
CI  - Copyright (c) 2022 Krzysztof Dabkowski et al.
FAU - Dabkowski, Krzysztof
AU  - Dabkowski K
AUID- ORCID: 0000-0002-5386-9004
AD  - Department of Gastroenterology, Faculty of Medicine and Dentistry, Pomeranian 
      Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
FAU - Labedz-Maslowska, Anna
AU  - Labedz-Maslowska A
AD  - Department of Cell Biology, Faculty of Biochemistry, Biophysics and 
      Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
FAU - Dolegowska, Barbara
AU  - Dolegowska B
AD  - Department of Microbiology, Immunology and Laboratory Medicine, Faculty of 
      Medicine and Dentistry, Aleja Powstancow Wielkopolskich 72, 70-111 Szczecin, 
      Poland.
FAU - Safranow, Krzysztof
AU  - Safranow K
AUID- ORCID: 0000-0001-9415-2758
AD  - Department of Biochemistry and Medical Chemistry, Faculty of Medicine and 
      Dentistry Pomeranian Medical University, Aleja Powstancow Wielkopolskich 72, 
      70-111 Szczecin, Poland.
FAU - Budkowska, Marta
AU  - Budkowska M
AD  - Department of Medical Analytics, Faculty of Medicine and Dentistry Pomeranian 
      Medical University, Aleja Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
FAU - Zuba-Surma, Ewa
AU  - Zuba-Surma E
AD  - Department of Cell Biology, Faculty of Biochemistry, Biophysics and 
      Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
FAU - Starzynska, Teresa
AU  - Starzynska T
AD  - Department of Gastroenterology, Faculty of Medicine and Dentistry, Pomeranian 
      Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
LA  - eng
PT  - Journal Article
DEP - 20220708
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC9286984
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/19 06:00
MHDA- 2022/07/19 06:01
PMCR- 2022/07/08
CRDT- 2022/07/18 04:09
PHST- 2022/04/15 00:00 [received]
PHST- 2022/06/27 00:00 [accepted]
PHST- 2022/07/18 04:09 [entrez]
PHST- 2022/07/19 06:00 [pubmed]
PHST- 2022/07/19 06:01 [medline]
PHST- 2022/07/08 00:00 [pmc-release]
AID - 10.1155/2022/5395248 [doi]
PST - epublish
SO  - Stem Cells Int. 2022 Jul 8;2022:5395248. doi: 10.1155/2022/5395248. eCollection 
      2022.