PMID- 35847088
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231103
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 13
DP  - 2022
TI  - Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment.
PG  - 931440
LID - 10.3389/fmicb.2022.931440 [doi]
LID - 931440
AB  - Many agricultural pesticides include substances that are known to be harmful to 
      human health and while some have been banned from developed countries, they are 
      still being used in developing countries such as Brazil. Recent studies have 
      shown that low-level chronic dietary exposure to pesticides can affect the human 
      gut microbiota. This possible hazardous effect of pesticides on human health has 
      not been specifically recognized by government regulatory agencies. In Brazil, 
      for instance, of the 10 best-selling active ingredients in pesticides in 2019, 
      two are considered extremely toxic, Paraquat and Chlorpyrifos. Even though 
      Paraquat has been banned in Brazil since 2020, the values of maximum residue 
      limits (MRLs) of toxic pesticides allowed in the country are still higher than in 
      other countries. Unfortunately, many developing countries still lack the 
      resources and expertise needed to monitor adequately and systematically the 
      presence of pesticide residues on food. In this work, we raise awareness to the 
      danger the chronic exposure to high dietary levels of pesticides can pose to the 
      public, especially considering their prolonged effects on the gut microbiome.
CI  - Copyright (c) 2022 Gama, Neves and Pereira.
FAU - Gama, Jessica
AU  - Gama J
AD  - Graduate Program in Neuroscience and Cell Biology, Federal University of Para, 
      Belem, Brazil.
FAU - Neves, Bianca
AU  - Neves B
AD  - Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, 
      Brazil.
FAU - Pereira, Antonio
AU  - Pereira A
AD  - Graduate Program in Neuroscience and Cell Biology, Federal University of Para, 
      Belem, Brazil.
AD  - Institute of Technology, Federal University of Para, Belem, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220630
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC9279132
OTO - NOTNLM
OT  - dysbiosis
OT  - gut- brain axis
OT  - microbiome
OT  - neurodevelopment and plasticity
OT  - pesticides
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/19 06:00
MHDA- 2022/07/19 06:01
PMCR- 2022/06/30
CRDT- 2022/07/18 04:11
PHST- 2022/04/29 00:00 [received]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2022/07/18 04:11 [entrez]
PHST- 2022/07/19 06:00 [pubmed]
PHST- 2022/07/19 06:01 [medline]
PHST- 2022/06/30 00:00 [pmc-release]
AID - 10.3389/fmicb.2022.931440 [doi]
PST - epublish
SO  - Front Microbiol. 2022 Jun 30;13:931440. doi: 10.3389/fmicb.2022.931440. 
      eCollection 2022.