PMID- 35848373 OWN - NLM STAT- MEDLINE DCOM- 20221130 LR - 20230113 IS - 1097-0193 (Electronic) IS - 1065-9471 (Print) IS - 1065-9471 (Linking) VI - 43 IP - 18 DP - 2022 Dec 15 TI - Automatic auditory processing features in distinct subtypes of patients at clinical high risk for psychosis: Forecasting remission with mismatch negativity. PG - 5452-5464 LID - 10.1002/hbm.26021 [doi] AB - Individuals at clinical high risk (CHR) for psychosis exhibit a compromised mismatch negativity (MMN) response, which indicates dysfunction of pre-attentive deviance processing. Event-related potential and time-frequency (TF) information, in combination with clinical and cognitive profiles, may provide insight into the pathophysiology and psychopathology of the CHR stage and predict the prognosis of CHR individuals. A total of 92 individuals with CHR were recruited and followed up regularly for up to 3 years. Individuals with CHR were classified into three clinical subtypes demonstrated previously, specifically 28 from Cluster 1 (characterized by extensive negative symptoms and cognitive deficits), 31 from Cluster 2 (characterized by thought and behavioral disorganization, with moderate cognitive impairment), and 33 from Cluster 3 (characterized by the mildest symptoms and cognitive deficits). Auditory MMN to frequency and duration deviants was assessed. The event-related spectral perturbation (ERSP) and inter-trial coherence (ITC) were acquired using TF analysis. Predictive indices for remission were identified using logistic regression analyses. As expected, reduced frequency MMN (fMMN) and duration MMN (dMMN) responses were noted in Cluster 1 relative to the other two clusters. In the TF analysis, Cluster 1 showed decreased theta and alpha ITC in response to deviant stimuli. The regression analyses revealed that dMMN latency and alpha ERSP to duration deviants, theta ITC to frequency deviants and alpha ERSP to frequency deviants, and fMMN latency were significant MMN predictors of remission for the three clusters. MMN variables outperformed behavioral variables in predicting remission of Clusters 1 and 2. Our findings indicate relatively disrupted automatic auditory processing in a certain CHR subtype and a close affinity between these electrophysiological indexes and clinical profiles within different clusters. Furthermore, MMN indexes may serve as predictors of subsequent remission from the CHR state. These findings suggest that the auditory MMN response is a potential neurophysiological marker for distinct clinical subtypes of CHR. CI - (c) 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. FAU - Wu, GuiSen AU - Wu G AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. FAU - Tang, XiaoChen AU - Tang X AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. FAU - Gan, RanPiao AU - Gan R AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. FAU - Zeng, JiaHui AU - Zeng J AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. FAU - Hu, YeGang AU - Hu Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. FAU - Xu, LiHua AU - Xu L AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. FAU - Wei, YanYan AU - Wei Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. FAU - Tang, YingYing AU - Tang Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. FAU - Chen, Tao AU - Chen T AD - Big Data Research Lab, University of Waterloo, Ontario, Canada. AD - Labor and Worklife Program, Harvard University, Cambridge, Massachusetts, USA. AD - Niacin (Shanghai) Technology Co., Ltd., Shanghai, People's Republic of China. FAU - Liu, HaiChun AU - Liu H AD - Department of Automation, Shanghai Jiao Tong University, Shanghai, People's Republic of China. FAU - Li, ChunBo AU - Li C AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. FAU - Wang, JiJun AU - Wang J AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. AD - CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Beijing, People's Republic of China. AD - Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai, People's Republic of China. FAU - Zhang, TianHong AU - Zhang T AUID- ORCID: 0000-0002-5379-7119 AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220718 PL - United States TA - Hum Brain Mapp JT - Human brain mapping JID - 9419065 SB - IM MH - Humans MH - *Schizophrenia MH - Electroencephalography MH - *Psychotic Disorders MH - Auditory Perception/physiology MH - Evoked Potentials/physiology MH - Evoked Potentials, Auditory/physiology MH - Acoustic Stimulation PMC - PMC9704791 OTO - NOTNLM OT - event-related spectral perturbation OT - inter-trial coherence OT - mismatch negativity OT - remission OT - subtypes OT - ultra-high risk COIS- The authors declare no conflict of interest. EDAT- 2022/07/19 06:00 MHDA- 2022/12/01 06:00 PMCR- 2022/07/18 CRDT- 2022/07/18 05:23 PHST- 2022/06/21 00:00 [revised] PHST- 2022/05/19 00:00 [received] PHST- 2022/07/02 00:00 [accepted] PHST- 2022/07/19 06:00 [pubmed] PHST- 2022/12/01 06:00 [medline] PHST- 2022/07/18 05:23 [entrez] PHST- 2022/07/18 00:00 [pmc-release] AID - HBM26021 [pii] AID - 10.1002/hbm.26021 [doi] PST - ppublish SO - Hum Brain Mapp. 2022 Dec 15;43(18):5452-5464. doi: 10.1002/hbm.26021. Epub 2022 Jul 18.