PMID- 35849234
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20221122
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 59
DP  - 2022 Dec
TI  - Association of increased risk of cardiovascular diseases with higher levels of 
      perfluoroalkylated substances in the serum of adults.
PG  - 89081-89092
LID - 10.1007/s11356-022-22021-z [doi]
AB  - Evidence showing the association of perfluoroalkylated substance (PFAS) exposure 
      with CVD risk is scarce. The objective of this study was to explore the 
      relationships of CVD risk with mixed or individual serum PFAS levels among 
      general adults. We analyzed combined data of 7904 adults who participated in the 
      National Health and Nutrition Examination Survey 2003-2012 with a Bayesian kernel 
      machine regression (BKMR) to examine the relationships of individual or mixed 
      PFAS exposure with total CVD risk. A logistic regression model and restricted 
      cubic spline (RCS) regression with multivariate adjustment were conducted to 
      assess the relationships between individual serum PFAS levels and the risk of 
      total CVD or its subtypes. A mediation model was applied to investigate how 
      C-reactive protein (CRP) levels mediate the strength of the association. The BKMR 
      results indicated a positive relationship between mixed PFAS exposure and total 
      CVD risk; among the PFASs, perfluorooctane sulfonic acid (PFOS) had the highest 
      posterior inclusion probability. As determined by logistic regression, a log-unit 
      change in PFOS levels was positively related to a higher risk of heart attack and 
      stroke in males (both P < 0.05). A nonlinear relationship was found between PFOS 
      levels and stroke risk (P for nonlinearity = 0.04), as illustrated in the RCS 
      plot. The mediation analysis showed that CRP levels mediated 8% and 1.2% of the 
      relationship between serum PFOS and PFNA levels, respectively, and the prevalence 
      of stroke. A significant relationship between higher serum PFAS concentrations 
      and an increased risk of CVD was observed, mainly in males.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Feng, Xinghui
AU  - Feng X
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, 72 Guangzhou Road, Nanjing, 210008, China.
FAU - Long, Guangfeng
AU  - Long G
AD  - Department of Clinical Laboratory, Children's Hospital of Nanjing Medical 
      University, Nanjing, 210008, China.
FAU - Zeng, Guowei
AU  - Zeng G
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, 72 Guangzhou Road, Nanjing, 210008, China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, 72 Guangzhou Road, Nanjing, 210008, China.
FAU - Song, Binqian
AU  - Song B
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, 72 Guangzhou Road, Nanjing, 210008, China.
FAU - Wu, Kai-Hong
AU  - Wu KH
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, 72 Guangzhou Road, Nanjing, 210008, China. pumcwu@sina.com.
LA  - eng
GR  - ZDRCA2016073/Medical Science and Technology Development Foundation, Jiangsu 
      Provincial Commission of Health and Family Planning/
PT  - Journal Article
DEP - 20220718
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - 0 (Fluorocarbons)
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Male
MH  - *Fluorocarbons
MH  - Nutrition Surveys
MH  - *Cardiovascular Diseases/epidemiology
MH  - Bayes Theorem
MH  - *Alkanesulfonic Acids
MH  - *Stroke
MH  - *Environmental Pollutants
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Cardiovascular disease
OT  - Mediation analysis
OT  - NHANES
OT  - Perfluoroalkylated substances
EDAT- 2022/07/19 06:00
MHDA- 2022/11/23 06:00
CRDT- 2022/07/18 11:18
PHST- 2022/05/13 00:00 [received]
PHST- 2022/07/11 00:00 [accepted]
PHST- 2022/07/19 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/07/18 11:18 [entrez]
AID - 10.1007/s11356-022-22021-z [pii]
AID - 10.1007/s11356-022-22021-z [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Dec;29(59):89081-89092. doi: 
      10.1007/s11356-022-22021-z. Epub 2022 Jul 18.