PMID- 35849505
OWN - NLM
STAT- MEDLINE
DCOM- 20220721
LR  - 20220810
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 74
IP  - 6
DP  - 2022 Jun 1
TI  - Endoluminal Functional Lumen Imaging Probe Is Safe in Children Under Five Years 
      Old.
PG  - e148-e152
LID - 10.1097/MPG.0000000000003430 [doi]
AB  - BACKGROUND: Endoluminal functional lumen imaging probe (EndoFLIP) is a minimally 
      invasive, novel device that uses high-resolution impedance planimetry to measure 
      important parameters of the gastrointestinal lumen that aid in the diagnosis of 
      esophageal disorders. EndoFLiP is approved by the US Food and Drug Administration 
      (FDA) for children 5 years and older. We sought to compare its safety and luminal 
      characteristics between children under 5 years of age with children 5 years and 
      older. METHODS: A single-center retrospective review was performed to identify 
      all patients < 21 years of age who underwent esophagogastroduodenoscopy (EGD) 
      with EndoFLIP between October 2017 and November 2020. Results: Sixty-seven EGDs 
      with EndoFLIP were performed in 56 patients, including 14 that were done in 
      children < 5 years and 53 in children >/=5years. The median age in the < 5-year 
      group was 1.7years (interquartile range [IQR], 0.9-4.4) and the youngest patient 
      was 1 month old. The median age in >/=5-year group was 14.3 years (IQR, 8.2-16.2). 
      Median procedure times were similar (32 minutes [IQR, 25-48] for the < 5-year 
      group; 28 minutes [IQR, 20-33] for >/=5-year group; P  = 0.08). There were no 
      adverse events or unplanned hospitalizations in either group. At 30 mL inflation, 
      the pressure of the lower esophageal sphincter (LES) was statistically different 
      between the 2 groups (P = 0.02). CONCLUSION: EndoFLIP appears to be safe for use 
      in our small cohort of children < 5 years of age and may be an important tool in 
      the management of esophageal disorders in this age group. There was no difference 
      in procedure time between our 2 age groups and there were no procedure-related 
      complications.
CI  - Copyright (c) 2022 by European Society for Pediatric Gastroenterology, Hepatology, 
      and Nutrition and North American Society for Pediatric Gastroenterology, 
      Hepatology, and Nutrition.
FAU - Hoskins, Brett
AU  - Hoskins B
AD  - The Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department 
      of Pediatrics, The Johns Hopkins University School of Medicine.
FAU - Almazan, Erik
AU  - Almazan E
AD  - The Johns Hopkins University School of Medicine, Baltimore, MD.
FAU - Mogul, Douglas
AU  - Mogul D
AD  - The Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department 
      of Pediatrics, The Johns Hopkins University School of Medicine.
FAU - Ng, Kenneth
AU  - Ng K
AD  - The Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department 
      of Pediatrics, The Johns Hopkins University School of Medicine.
LA  - eng
PT  - Journal Article
DEP - 20220224
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Electric Impedance
MH  - *Esophageal Diseases
MH  - *Esophageal Sphincter, Lower/surgery
MH  - Humans
MH  - Infant
MH  - Retrospective Studies
COIS- The authors report no conflicts of interest.
EDAT- 2022/07/19 06:00
MHDA- 2022/07/22 06:00
CRDT- 2022/07/18 12:38
PHST- 2022/07/18 12:38 [entrez]
PHST- 2022/07/19 06:00 [pubmed]
PHST- 2022/07/22 06:00 [medline]
AID - 00005176-202206000-00021 [pii]
AID - 10.1097/MPG.0000000000003430 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2022 Jun 1;74(6):e148-e152. doi: 
      10.1097/MPG.0000000000003430. Epub 2022 Feb 24.