PMID- 35851317
OWN - NLM
STAT- MEDLINE
DCOM- 20220721
LR  - 20220927
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jul 18
TI  - Branched-chain and aromatic amino acid levels response to an oral glucose load 
      associated with gestational diabetes mellitus.
PG  - 12257
LID - 10.1038/s41598-022-16539-y [doi]
LID - 12257
AB  - Serum branched chain amino acids (BCAAs) and aromatic amino acids (AAAs) are 
      associated with obesity, insulin resistance and type 2 diabetes mellitus (T2DM). 
      We investigated the levels of these amino acids in women with gestational 
      diabetes mellitus (GDM) and examined their changes in response to an oral glucose 
      tolerance test (OGTT). 110 women were enrolled and underwent a 75-g OGTT during 
      their second trimester; 43 women were diagnosed with GDM and 67 women did not 
      have GDM (non-GDM women). During the OGTT, fasting, 1-h, and 2-h blood samples 
      were obtained. BCAA and AAA levels were measured by liquid chromatography-tandem 
      mass spectrometry. The differences in BCAA and AAA levels between GDM and non-GDM 
      women were not evident during fasting but became significant after glucose 
      loading. Glucose ingestion decreased the levels of BCAAs and AAAs in both groups. 
      Notably, GDM women showed a delayed and blunted decrease in these amino acids 
      compared to non-GDM women. The risks of 2-h changes in BCAAs and AAAs for GDM 
      women were significant. We identified that the differences in BCAA and AAA levels 
      between GDM women and controls, which were not evident during fasting, could be 
      provoked by performing an OGTT.
CI  - (c) 2022. The Author(s).
FAU - Gao, BeiBei
AU  - Gao B
AD  - Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou Municipal Hospital, Suzhou, 215000, China.
FAU - Shen, Qiong
AU  - Shen Q
AD  - Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou Municipal Hospital, Suzhou, 215000, China.
FAU - Wu, Ying
AU  - Wu Y
AD  - Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou Municipal Hospital, Suzhou, 215000, China.
FAU - Cao, MengDie
AU  - Cao M
AD  - Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou Municipal Hospital, Suzhou, 215000, China.
FAU - Zhang, QiWu
AU  - Zhang Q
AD  - Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou Municipal Hospital, Suzhou, 215000, China.
FAU - Chen, Lei
AU  - Chen L
AD  - Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou Municipal Hospital, Suzhou, 215000, China. szslyynfm@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220718
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Amino Acids)
RN  - 0 (Amino Acids, Aromatic)
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Blood Glucose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Amino Acids
MH  - Amino Acids, Aromatic
MH  - Amino Acids, Branched-Chain
MH  - Blood Glucose/metabolism
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - *Diabetes, Gestational
MH  - Female
MH  - Glucose
MH  - Humans
MH  - Pregnancy
PMC - PMC9293928
COIS- The authors declare no competing interests.
EDAT- 2022/07/20 06:00
MHDA- 2022/07/22 06:00
PMCR- 2022/07/18
CRDT- 2022/07/19 08:16
PHST- 2021/12/30 00:00 [received]
PHST- 2022/07/12 00:00 [accepted]
PHST- 2022/07/19 08:16 [entrez]
PHST- 2022/07/20 06:00 [pubmed]
PHST- 2022/07/22 06:00 [medline]
PHST- 2022/07/18 00:00 [pmc-release]
AID - 10.1038/s41598-022-16539-y [pii]
AID - 16539 [pii]
AID - 10.1038/s41598-022-16539-y [doi]
PST - epublish
SO  - Sci Rep. 2022 Jul 18;12(1):12257. doi: 10.1038/s41598-022-16539-y.