PMID- 35851677
OWN - NLM
STAT- MEDLINE
DCOM- 20230321
LR  - 20230321
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 201
IP  - 5
DP  - 2023 May
TI  - Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with 
      Type 2 Diabetes.
PG  - 2266-2273
LID - 10.1007/s12011-022-03357-6 [doi]
AB  - We aimed to explore whether an elevated blood lead level (BLL) is associated with 
      visceral adipose dysfunction in patients with type 2 diabetes mellitus (T2DM). 
      Four thousand one hundred and fourteen diabetic participants were enrolled from 
      seven communities in Shanghai in 2018 in the cross-sectional METAL study. BLL was 
      measured by graphite furnace atomic absorption spectrometry. Visceral adiposity 
      index (VAI) and lipid accumulation product (LAP)were calculated by simple 
      anthropometric and biochemical parameters. We found that medians (IQR) of BLL 
      were 26.0 mug/L (18.0-37.0) for men and 25.0 mug/L (18.0-35.0) for women, 
      respectively. In men, each doubling of BLL was associated with a 2.0% higher VAI 
      (95% CI, 0.6 to 3.5%) and 1.8% higher LAP (95% CI, 0.2 to 3.3%) after full 
      adjustment. Using the lowest BLL quartile as the referent group, significant 
      positive trends were observed for BLL with VAI and LAP. In women, each doubling 
      of BLL was associated with a 1.9% higher LAP (95% CI, 0.6 to 3.1%). Additionally, 
      there was a marginally significant positive association between BLL and VAI, 
      either using log2-transformed concentrations as continuous variables or 
      categorized in quartiles. In conclusion, lead exposure is associated with 
      visceral adipose dysfunction in patients with T2DM. Further prospective studies 
      are warranted to confirm our findings.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Chen, Chi
AU  - Chen C
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, 639, Zhizaoju Road, 
      Shanghai, 200011, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, 639, Zhizaoju Road, 
      Shanghai, 200011, China.
FAU - Zhang, Haojie
AU  - Zhang H
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, 639, Zhizaoju Road, 
      Shanghai, 200011, China.
FAU - Wang, Yuying
AU  - Wang Y
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, 639, Zhizaoju Road, 
      Shanghai, 200011, China.
FAU - Yu, Shiyan
AU  - Yu S
AD  - Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Zhou, Shuo
AU  - Zhou S
AD  - Department of Anesthesiology, Shenzhen People's Hospital (The Second Clinical 
      Medical College, Jinan University, The First Affiliated Hospital, Southern 
      University of Science and Technology), Shenzhen, China.
FAU - Chen, Yi
AU  - Chen Y
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, 639, Zhizaoju Road, 
      Shanghai, 200011, China.
FAU - Xia, Fangzhen
AU  - Xia F
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, 639, Zhizaoju Road, 
      Shanghai, 200011, China.
FAU - Zhai, Hualing
AU  - Zhai H
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, 639, Zhizaoju Road, 
      Shanghai, 200011, China. zhaihualing@126.com.
FAU - Wang, Ningjian
AU  - Wang N
AD  - Department of Endocrinology and Metabolism, Huangpu Branch, Shanghai Ninth 
      People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 
      China. wnj486@126.com.
FAU - Lu, Yingli
AU  - Lu Y
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, 639, Zhizaoju Road, 
      Shanghai, 200011, China. luyingli2008@126.com.
LA  - eng
PT  - Journal Article
DEP - 20220718
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Lead
MH  - Adiposity
MH  - Cross-Sectional Studies
MH  - China
MH  - Obesity, Abdominal/complications
MH  - Body Mass Index
OTO - NOTNLM
OT  - Epidemiology
OT  - Lead
OT  - Type 2 diabetes mellitus
OT  - Visceral adipose dysfunction
EDAT- 2022/07/20 06:00
MHDA- 2023/03/22 06:00
CRDT- 2022/07/19 08:39
PHST- 2022/04/13 00:00 [received]
PHST- 2022/07/10 00:00 [accepted]
PHST- 2022/07/20 06:00 [pubmed]
PHST- 2023/03/22 06:00 [medline]
PHST- 2022/07/19 08:39 [entrez]
AID - 10.1007/s12011-022-03357-6 [pii]
AID - 10.1007/s12011-022-03357-6 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2023 May;201(5):2266-2273. doi: 10.1007/s12011-022-03357-6. 
      Epub 2022 Jul 18.