PMID- 35851968
OWN - NLM
STAT- MEDLINE
DCOM- 20221011
LR  - 20230107
IS  - 1600-0463 (Electronic)
IS  - 0903-4641 (Print)
IS  - 0903-4641 (Linking)
VI  - 130
IP  - 11
DP  - 2022 Nov
TI  - Vancomycin-resistant Enterococcus faecium: should we screen on admission?
PG  - 657-660
LID - 10.1111/apm.13263 [doi]
AB  - Denmark has experienced an increase in the proportion of invasive 
      vancomycin-resistant Enterococcus faecium (VRE) since 2002 (e.g. <4% in 2015, 
      7.1% in 2017 and 12% in 2018). At Rigshospitalet, we employ active screening at 
      departments with high prevalence or in case of outbreaks. This includes the 
      collection of rectal swabs specifically for VRE screening. Our purpose was to 
      describe the carrier prevalence of vancomycin-resistant enterococci among acute 
      patients admitted to the Neurointensive Care Unit, Department of 
      Neuroanaesthesiology, Rigshospitalet, Copenhagen, Denmark (NICU). Between April 
      2018 and January 2019, we investigated 99 consecutive rectal swabs from patients 
      admitted to NICU. The primary outcome was prevalence of VRE carriage. The median 
      age was 64 years (range 23-87) and gender was equally distributed (Female = 47, 
      Male = 46). 26 (28%) had previously been admitted within 179 days and 67 patients 
      (72%) had no hospital admissions within 180 days prior to the admission to NICU. 
      Of the 93 rectal swabs, 2 (2%, 95% CI 0.26-7.55%) were positive for vanA and none 
      were positive for vanB. Routine screening of all patients at admission may be 
      effective in hospital settings with high VRE prevalence, whereas the benefit of 
      screening for VRE in hospitals with a low prevalence may be restricted to 
      specific patient populations.
CI  - (c) 2022 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of 
      Scandinavian Societies for Medical Microbiology and Pathology.
FAU - Hertz, Frederik Boetius
AU  - Hertz FB
AD  - Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Nielsen, Karen Leth
AU  - Nielsen KL
AD  - Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Olsen, Markus Harboe
AU  - Olsen MH
AD  - Department of Neuroanaesthesiology, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Ebdrup, Soren Roddik
AU  - Ebdrup SR
AD  - Department of Neuroanaesthesiology, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Nielsen, Christina
AU  - Nielsen C
AD  - Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Kirkby, Nikolai Soren
AU  - Kirkby NS
AD  - Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Frimodt-Moller, Niels
AU  - Frimodt-Moller N
AD  - Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Moller, Kirsten
AU  - Moller K
AD  - Department of Neuroanaesthesiology, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
AD  - Department of Clinical Medicine, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
LA  - eng
GR  - MICA-foundation/
PT  - Journal Article
DEP - 20220826
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
RN  - 0 (Anti-Bacterial Agents)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/pharmacology
MH  - *Enterococcus faecium
MH  - Female
MH  - *Gram-Positive Bacterial Infections/diagnosis/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Vancomycin
MH  - Vancomycin Resistance
MH  - *Vancomycin-Resistant Enterococci
MH  - Young Adult
PMC - PMC9805049
OTO - NOTNLM
OT  - VRE
OT  - active screening
OT  - bacteriology
OT  - clinical microbiology
OT  - multidrug resistance
COIS- Frederik Boetius Hertz have received honoraria from B. Braun Medical A/S and 
      Triggerz ApS. The remaining authors have no conflicts of interest to declare.
EDAT- 2022/07/20 06:00
MHDA- 2022/10/12 06:00
PMCR- 2022/12/31
CRDT- 2022/07/19 08:56
PHST- 2022/07/05 00:00 [received]
PHST- 2022/07/09 00:00 [accepted]
PHST- 2022/07/20 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/07/19 08:56 [entrez]
PHST- 2022/12/31 00:00 [pmc-release]
AID - APM13263 [pii]
AID - 10.1111/apm.13263 [doi]
PST - ppublish
SO  - APMIS. 2022 Nov;130(11):657-660. doi: 10.1111/apm.13263. Epub 2022 Aug 26.