PMID- 35853342
OWN - NLM
STAT- MEDLINE
DCOM- 20220809
LR  - 20220920
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 244
DP  - 2022 Jul
TI  - Joint association of polycyclic aromatic hydrocarbons and heavy metal exposure 
      with pulmonary function in children and adolescents aged 6-19 years.
PG  - 114007
LID - S1438-4639(22)00090-6 [pii]
LID - 10.1016/j.ijheh.2022.114007 [doi]
AB  - Studies have reported associations between polycyclic aromatic hydrocarbon (PAH) 
      or heavy metal (HM) exposure and respiratory diseases. However, evidence of their 
      joint associations with pulmonary function, especially in children and 
      adolescents aged 6-19 years, is lacking. We utilized cross-sectional data from 
      1,734 children and adolescents aged 6-19 years collected in the National Health 
      and Nutrition Examination Survey 2007-2012 and analysed mixed PAH and mixed HM 
      exposures and their joint association with pulmonary function by applying 
      weighted quantile sum (WQS) regression and Bayesian kernel machine regression 
      (BKMR). Multivariate linear regressions were carried out to determine the 
      relationships between individual urinary PAH metabolites or blood HM levels and 
      pulmonary function indices. We found that mixed PAHs and HMs were negatively 
      related to forced expiratory volume in 1 s (FEV1) in subjects aged 6-12 years 
      (all p values < 0.05). We found synergistic associations of PAH and HM exposure 
      on pulmonary function impairment, mainly in children; lead (Pb) was the most 
      damaging. In the analysis of individual PAH metabolites or HMs, Pb exposure was 
      negatively associated with FEV1 values in all subgroups (all p values < 0.05). 
      Thus, our findings indicate that increased PAH or HM exposure is associated with 
      impairments to pulmonary function and that this association is more pronounced in 
      children.
CI  - Copyright (c) 2022 Elsevier GmbH. All rights reserved.
FAU - Feng, Xinghui
AU  - Feng X
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, Nanjing, 210008, China.
FAU - Zeng, Guowei
AU  - Zeng G
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, Nanjing, 210008, China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, Nanjing, 210008, China.
FAU - Song, Binqian
AU  - Song B
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, Nanjing, 210008, China.
FAU - Wu, Kai-Hong
AU  - Wu KH
AD  - Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical 
      University, Nanjing, 210008, China. Electronic address: pumcwu@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220716
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Metals, Heavy)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Adolescent
MH  - Bayes Theorem
MH  - Child
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Lead
MH  - *Metals, Heavy
MH  - Nutrition Surveys
MH  - *Polycyclic Aromatic Hydrocarbons/urine
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Heavy metals
OT  - Joint association
OT  - Polycyclic aromatic hydrocarbons
OT  - Pulmonary function
OT  - Weighted quantile sum
EDAT- 2022/07/20 06:00
MHDA- 2022/08/10 06:00
CRDT- 2022/07/19 18:19
PHST- 2022/04/13 00:00 [received]
PHST- 2022/07/05 00:00 [revised]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/07/20 06:00 [pubmed]
PHST- 2022/08/10 06:00 [medline]
PHST- 2022/07/19 18:19 [entrez]
AID - S1438-4639(22)00090-6 [pii]
AID - 10.1016/j.ijheh.2022.114007 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2022 Jul;244:114007. doi: 10.1016/j.ijheh.2022.114007. 
      Epub 2022 Jul 16.