PMID- 35853345
OWN - NLM
STAT- MEDLINE
DCOM- 20220824
LR  - 20220912
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 35
DP  - 2022
TI  - A systematic review on resting state functional connectivity in patients with 
      neurodegenerative disease and hallucinations.
PG  - 103112
LID - S2213-1582(22)00177-2 [pii]
LID - 10.1016/j.nicl.2022.103112 [doi]
LID - 103112
AB  - Hallucinations are a complex and multidimensional phenomenon which can differ 
      based on the involved pathology, typology and sensory modality. Hallucinations 
      are common in patients with neurodegenerative diseases. Recent sparse evidence 
      from resting state functional magnetic resonance imaging (rs-fMRI) studies has 
      identified altered functional connectivity in those patients within several brain 
      networks, such as the default mode, attentional and sensory ones, without, 
      however, providing an organized picture of the mechanisms involved. This 
      systematic review, following PRISMA guidelines, aims at critically analyzing the 
      current literature on the brain networks associated with the phenomenon of 
      hallucinations in patients with neurodegenerative diseases. Ten rs-fMRI studies 
      fulfilled our selection criteria. All these studies focused on synucleinopathies, 
      and most of them focused on visual hallucinations and were characterized by a 
      heterogeneous methodology. Thus, instead of offering a definite picture of the 
      mechanisms underlying hallucinations in neurodegeneration, this systematic review 
      encourages further research especially concerning tauopathies. Notwithstanding, 
      the findings overall suggest a disruption in the top-down (associated with memory 
      intrusion and difficulty of inhibition) and in the bottom-up processes 
      (associated with the sensory areas involved in the hallucinations). Further 
      investigations are needed in order to disentangle the brain mechanisms involved 
      in hallucinations and to overcome possible limitations characterizing the current 
      literature.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Spinosa, Vittoria
AU  - Spinosa V
AD  - Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical 
      Research in Neurology, University of Bari "Aldo Moro", "Pia Fondazione Cardinale 
      G. Panico", Tricase, Lecce, Italy; Department of Basic Medicine, Neuroscience, 
      and Sense Organs, University of Bari "Aldo Moro", Bari, Italy.
FAU - Brattico, Elvira
AU  - Brattico E
AD  - Center for Music in the Brain (MIB), Department of Clinical Medicine, Aarhus 
      University & Royal Academy of Music Aarhus/Aalborg, Aarhus, Denmark; Department 
      of Education, Psychology, Communication, University of Bari "Aldo Moro", Bari, 
      Italy.
FAU - Campo, Fulvia
AU  - Campo F
AD  - Center for Music in the Brain (MIB), Department of Clinical Medicine, Aarhus 
      University & Royal Academy of Music Aarhus/Aalborg, Aarhus, Denmark; Department 
      of Education, Psychology, Communication, University of Bari "Aldo Moro", Bari, 
      Italy.
FAU - Logroscino, Giancarlo
AU  - Logroscino G
AD  - Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical 
      Research in Neurology, University of Bari "Aldo Moro", "Pia Fondazione Cardinale 
      G. Panico", Tricase, Lecce, Italy; Department of Basic Medicine, Neuroscience, 
      and Sense Organs, University of Bari "Aldo Moro", Bari, Italy. Electronic 
      address: giancarlo.logroscino@uniba.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20220713
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
MH  - Brain
MH  - Brain Mapping
MH  - Hallucinations/diagnostic imaging/etiology/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Neurodegenerative Diseases/pathology
PMC - PMC9421441
OTO - NOTNLM
OT  - Hallucination
OT  - Neurodegenerative disorders
OT  - Predictive coding
OT  - Resting state fMRI
OT  - Systematic review
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/07/20 06:00
MHDA- 2022/08/25 06:00
PMCR- 2022/07/13
CRDT- 2022/07/19 18:20
PHST- 2022/03/01 00:00 [received]
PHST- 2022/06/17 00:00 [revised]
PHST- 2022/07/10 00:00 [accepted]
PHST- 2022/07/20 06:00 [pubmed]
PHST- 2022/08/25 06:00 [medline]
PHST- 2022/07/19 18:20 [entrez]
PHST- 2022/07/13 00:00 [pmc-release]
AID - S2213-1582(22)00177-2 [pii]
AID - 103112 [pii]
AID - 10.1016/j.nicl.2022.103112 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2022;35:103112. doi: 10.1016/j.nicl.2022.103112. Epub 2022 Jul 
      13.