PMID- 35853363 OWN - NLM STAT- MEDLINE DCOM- 20220823 LR - 20220823 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 242 DP - 2022 Sep 1 TI - Associations between phthalate exposure and thyroid function in pregnant women during the first trimester. PG - 113884 LID - S0147-6513(22)00724-2 [pii] LID - 10.1016/j.ecoenv.2022.113884 [doi] AB - Phthalates are a class of environmental endocrine disruptors. Previous studies have demonstrated that phthalate exposure can affect thyroid function; however, limited studies have assessed the associations between phthalate exposure and thyroid function, especially thyroid autoimmunity in pregnant women during the first trimester. We recruited participants from a cohort of pregnant women in Beijing, China, and collected urine samples to measure ten phthalate metabolites, serum samples to measure free thyroxine (FT(4)), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb) during the first trimester. We included 325 pregnant women without thyroid diseases or dysfunction in this study. Associations between phthalate metabolites and thyroid function parameters were assessed with the Bayesian kernel machine regression (BKMR) model, multiple linear regression model, and restricted cubic spline. In the BKMR model analysis, compared to the 50th percentile, total urinary phthalate metabolites levels were negatively associated with serum TPOAb levels when phthalate metabolites were at or below the 40th percentile. Stratifying by body mass index, total urinary phthalate metabolites levels were negatively associated with serum TPOAb levels in normal weight women when phthalate metabolites were at or below the 45th percentile. However, total urinary phthalate metabolites levels were positively associated with serum TPOAb levels in underweight women when phthalate metabolites were at or below the 30th percentile. In restricted cubic spline analysis, L-shaped nonlinear associations of mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), di-(2-ethylhexyl) phthalate (SigmaDEHP), and inverted S-shaped nonlinear association of mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) with TPOAb were observed. In conclusion, our findings suggest that phthalate exposure may affect thyroid autoimmunity in underweight pregnant women during early pregnancy, and the potential effects of phthalate exposure on thyroid autoimmunity may be nonlinear. CI - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Yang, Zheng AU - Yang Z AD - Department of Toxicology, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. FAU - Zhang, Tao AU - Zhang T AD - Department of Toxicology, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. FAU - Shan, Danping AU - Shan D AD - Department of Toxicology, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. FAU - Li, Ludi AU - Li L AD - Department of Toxicology, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. FAU - Wang, Shuo AU - Wang S AD - Department of Toxicology, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. FAU - Li, Yingzi AU - Li Y AD - Department of Toxicology, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. FAU - Du, Ruihu AU - Du R AD - Department of Toxicology, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. FAU - Wu, Shaowei AU - Wu S AD - Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. FAU - Jin, Lei AU - Jin L AD - Institute of Reproductive and Child Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. FAU - Lu, Xin AU - Lu X AD - Maternal and Child Health Care Hospital of Haidian District, Beijing 100080, China. FAU - Shang, Xuejun AU - Shang X AD - Department of Andrology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China. FAU - Wang, Qi AU - Wang Q AD - Department of Toxicology, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. Electronic address: wangqi@bjmu.edu.cn. LA - eng PT - Journal Article DEP - 20220716 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - 0 (Environmental Pollutants) RN - 0 (Phthalic Acids) RN - 6O7F7IX66E (phthalic acid) RN - C42K0PH13C (Diethylhexyl Phthalate) SB - IM MH - Bayes Theorem MH - *Diethylhexyl Phthalate MH - Environmental Exposure MH - *Environmental Pollutants/toxicity/urine MH - Female MH - Humans MH - *Phthalic Acids/urine MH - Pregnancy MH - Pregnancy Trimester, First MH - Pregnant Women MH - Thinness MH - Thyroid Gland/metabolism OTO - NOTNLM OT - Bayesian kernel machine regression OT - First trimester OT - Phthalate OT - Pregnant women OT - Thyroid EDAT- 2022/07/20 06:00 MHDA- 2022/08/24 06:00 CRDT- 2022/07/19 18:22 PHST- 2022/05/09 00:00 [received] PHST- 2022/07/08 00:00 [revised] PHST- 2022/07/12 00:00 [accepted] PHST- 2022/07/20 06:00 [pubmed] PHST- 2022/08/24 06:00 [medline] PHST- 2022/07/19 18:22 [entrez] AID - S0147-6513(22)00724-2 [pii] AID - 10.1016/j.ecoenv.2022.113884 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2022 Sep 1;242:113884. doi: 10.1016/j.ecoenv.2022.113884. Epub 2022 Jul 16.