PMID- 35853407
OWN - NLM
STAT- MEDLINE
DCOM- 20220815
LR  - 20220815
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 272
DP  - 2022 Sep
TI  - Efficacy test of a plant-based porcine circovirus type 2 (PCV2) virus-like 
      particle vaccine against four PCV2 genotypes (2a, 2b, 2d, and 2e) in pigs.
PG  - 109512
LID - S0378-1135(22)00182-1 [pii]
LID - 10.1016/j.vetmic.2022.109512 [doi]
AB  - The objective of this study was to evaluate the efficacy of a recombinant porcine 
      circovirus type 2 (PCV2) vaccine based from a Nicotiana benthamiana expression 
      system against four different co-challenges with PCV2 genotypes (2a, 2b, 2d, and 
      2e) and porcine reproductive and respiratory syndrome virus (PRRSV). Pigs in the 
      vaccinated groups each received a 1.0 mL intramuscularly of plant-based PCV2a 
      vaccine in the neck muscle at 21 days of age. Vaccinates were then co-challenged 
      with a combination of one of four PCV2 genotypes (2a, 2b, 2d, and 2e) and PRRSV 
      at 42 days of age. Regardless of the PCV2 genotype used for challenge, 
      vaccination significantly reduced clinical signs, reduced the level of PCV2 load 
      in both blood and lymph nodes, and reduced the severity of lymphoid lesions in 
      pigs. Vaccination resulted in significantly higher titers of neutralizing 
      antibody against the corresponding PCV2 genotype evaluated and increased the 
      frequency of PCV2-specific interferon-gamma secreting cells. The results of this 
      study demonstrated that a plant-based PCV2 vaccine conferred protection against a 
      dual challenge with four different PCV2 genotypes when combined with PRRSV based 
      on clinical, virological, immunological and pathological evaluation.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, Republic of Korea.
FAU - Suh, Jeongmin
AU  - Suh J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, Republic of Korea.
FAU - Cho, Hyejean
AU  - Cho H
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, Republic of Korea.
FAU - Min, Kyungmin
AU  - Min K
AD  - BioApplications Inc., Pohang Techno Park Complex, 394 Jigok-ro, Nam-gu, Pohang 
      37668, Republic of Korea.
FAU - Choi, Bo-Hwa
AU  - Choi BH
AD  - BioApplications Inc., Pohang Techno Park Complex, 394 Jigok-ro, Nam-gu, Pohang 
      37668, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20220712
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Virus-Like Particle)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral
MH  - *Circoviridae Infections/prevention & control/veterinary
MH  - *Circovirus/genetics
MH  - Genotype
MH  - *Porcine respiratory and reproductive syndrome virus/genetics
MH  - Swine
MH  - *Swine Diseases
MH  - *Vaccines, Virus-Like Particle/genetics
MH  - *Viral Vaccines
OTO - NOTNLM
OT  - Plant-based porcine circovirus type 2 vaccine
OT  - Porcine circovirus associated disease
OT  - Porcine circovirus type 2d
EDAT- 2022/07/20 06:00
MHDA- 2022/08/16 06:00
CRDT- 2022/07/19 18:25
PHST- 2022/04/07 00:00 [received]
PHST- 2022/07/02 00:00 [revised]
PHST- 2022/07/09 00:00 [accepted]
PHST- 2022/07/20 06:00 [pubmed]
PHST- 2022/08/16 06:00 [medline]
PHST- 2022/07/19 18:25 [entrez]
AID - S0378-1135(22)00182-1 [pii]
AID - 10.1016/j.vetmic.2022.109512 [doi]
PST - ppublish
SO  - Vet Microbiol. 2022 Sep;272:109512. doi: 10.1016/j.vetmic.2022.109512. Epub 2022 
      Jul 12.