PMID- 35853854
OWN - NLM
STAT- MEDLINE
DCOM- 20220721
LR  - 20230119
IS  - 2041-4889 (Electronic)
VI  - 13
IP  - 7
DP  - 2022 Jul 19
TI  - Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an 
      indispensable coactivator for HIF-1alpha-induced transcription of CKAP2.
PG  - 625
LID - 10.1038/s41419-022-04880-z [doi]
LID - 625
AB  - Earlier studies have suggested deleted in lymphocytic leukemia 1 (DLEU1), a long 
      non-coding RNA, is a prognostic biomarker for breast cancer. Here we explored the 
      malignant behaviors and underlying mechanisms regulated by DLEU1 in breast 
      cancer. We demonstrated that up-regulation of DLEU1 was detected in breast cancer 
      tissues and cells, particularly in tumors of higher malignancy. DLEU1 knockdown 
      inhibited the growth and the motility of breast cancer cells. Mechanistically, 
      DLEU1 interacted with HIF-1alpha to collectively activate the transcription of CKAP2. 
      By activating ERK and STAT3 signaling, CKAP2 essentially mediated the pro-tumor 
      activities of DLEU1. In vivo, depletion of DLEU1 inhibited xenograft growth and 
      metastasis of breast cancer cells. Therefore, DLEU1, by acting as a coactivator 
      for HIF-1alpha, up-regulates CKAP2 expression and promotes malignancy of breast 
      cancer. Targeting DLEU1, HIF-1alpha, or CKAP2 may thus benefit breast cancer 
      treatment.
CI  - (c) 2022. The Author(s).
FAU - Ma, He Nan
AU  - Ma HN
AD  - Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou 
      University People's Hospital, Henan University People's Hospital, Zhengzhou, 
      450003, Henan Province, China.
FAU - Chen, Hai Jun
AU  - Chen HJ
AD  - Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou 
      University People's Hospital, Henan University People's Hospital, Zhengzhou, 
      450003, Henan Province, China.
FAU - Liu, Ji Quan
AU  - Liu JQ
AD  - Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou 
      University People's Hospital, Henan University People's Hospital, Zhengzhou, 
      450003, Henan Province, China.
FAU - Li, Wen Tao
AU  - Li WT
AUID- ORCID: 0000-0001-5160-1664
AD  - Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou 
      University People's Hospital, Henan University People's Hospital, Zhengzhou, 
      450003, Henan Province, China. liwentaolwt86@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220719
PL  - England
TA  - Cell Death Dis
JT  - Cell death & disease
JID - 101524092
RN  - 0 (CKAP2 protein, human)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DLEU1 lncRNA, human)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - *Breast Neoplasms/genetics/metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/physiology
MH  - Cell Proliferation/physiology
MH  - *Cytoskeletal Proteins/genetics/metabolism
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism
MH  - *RNA, Long Noncoding/genetics/metabolism
MH  - Transcriptional Activation
MH  - Tumor Suppressor Proteins/genetics/metabolism
PMC - PMC9296616
COIS- The authors declare no competing interests.
EDAT- 2022/07/20 06:00
MHDA- 2022/07/22 06:00
PMCR- 2022/07/19
CRDT- 2022/07/19 23:15
PHST- 2021/06/04 00:00 [received]
PHST- 2022/04/22 00:00 [accepted]
PHST- 2022/02/16 00:00 [revised]
PHST- 2022/07/19 23:15 [entrez]
PHST- 2022/07/20 06:00 [pubmed]
PHST- 2022/07/22 06:00 [medline]
PHST- 2022/07/19 00:00 [pmc-release]
AID - 10.1038/s41419-022-04880-z [pii]
AID - 4880 [pii]
AID - 10.1038/s41419-022-04880-z [doi]
PST - epublish
SO  - Cell Death Dis. 2022 Jul 19;13(7):625. doi: 10.1038/s41419-022-04880-z.