PMID- 35854898
OWN - NLM
STAT- MEDLINE
DCOM- 20220721
LR  - 20220728
IS  - 1178-2005 (Electronic)
IS  - 1176-9106 (Print)
IS  - 1176-9106 (Linking)
VI  - 17
DP  - 2022
TI  - Serum Derivatives of Reactive Oxygen Metabolites are Associated with Severity of 
      Chronic Obstructive Pulmonary Disease and Affected by a p53 Gene Polymorphism.
PG  - 1589-1600
LID - 10.2147/COPD.S366792 [doi]
AB  - PURPOSE: Oxidative stress is known to activate tumor suppressor p53, which 
      inhibits cell cycle progression and induces apoptosis. Levels of p53 in lung 
      tissues from patients with chronic obstructive pulmonary disease (COPD) are 
      increased compared with levels in nonsmokers or smokers without emphysema. A 
      polymorphism in p53 codon 72 (rs1042522) is associated with emphysematous changes 
      in patients with COPD. However, whether oxidative stress in the serum is 
      associated with the p53 polymorphism and disease severity in COPD patients is 
      unclear. PATIENTS AND METHODS: A total of 251 patients with a history of smoking 
      more than 10 pack-years were enrolled in this study, and serum levels of 
      derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant 
      potential (BAP), and d-ROMs/BAP ratio (oxidative stress index; OSI) were 
      measured. The percent low-attenuation area (LAA%) and cross-sectional area of the 
      erector spinae muscles (ESM(CSA)) at the Th(12) level were calculated from chest 
      high-resolution computed tomography images. p53 codon 72 C/G genotyping was 
      performed using polymerase chain reaction-restriction fragment length 
      polymorphism analysis. RESULTS: In patients carrying the p53 GG genotype, LAA% 
      was significantly higher than in those carrying the CC genotype. d-ROM levels and 
      OSI were associated with COPD severity and correlated with airflow limitation and 
      markers of muscle atrophy (ESM(CSA) and creatinine/cystatin C ratio). 
      Associations between markers of oxidative stress and COPD severity were observed 
      primarily in patients carrying the p53 codon 72 GG genotype. CONCLUSION: 
      Susceptibility to pulmonary emphysema and responses to oxidative stress may be 
      affected by the p53 gene polymorphism.
CI  - (c) 2022 Yamamura et al.
FAU - Yamamura, Koichi
AU  - Yamamura K
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
FAU - Nojiri, Masafumi
AU  - Nojiri M
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
FAU - Nishiki, Kazuaki
AU  - Nishiki K
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
FAU - Kato, Ryo
AU  - Kato R
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
FAU - Shinomiya, Shohei
AU  - Shinomiya S
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
FAU - Takahara, Yutaka
AU  - Takahara Y
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
FAU - Oikawa, Taku
AU  - Oikawa T
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
FAU - Ishizaki, Takeshi
AU  - Ishizaki T
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
FAU - Toga, Hirohisa
AU  - Toga H
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
FAU - Mizuno, Shiro
AU  - Mizuno S
AD  - Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220713
PL  - New Zealand
TA  - Int J Chron Obstruct Pulmon Dis
JT  - International journal of chronic obstructive pulmonary disease
JID - 101273481
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (TP53 protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - *Emphysema/complications
MH  - Humans
MH  - Polymorphism, Genetic
MH  - *Pulmonary Disease, Chronic Obstructive/complications/diagnosis/genetics
MH  - *Pulmonary Emphysema/blood/diagnosis/genetics
MH  - *Reactive Oxygen Species/blood
MH  - Tumor Suppressor Protein p53/genetics
PMC - PMC9289177
OTO - NOTNLM
OT  - low attenuation area
OT  - oxidative stress
OT  - sarcopenia
OT  - smoking status
COIS- The authors report no conflicts of interest in this work. The authors confirm 
      that the data supporting the findings of this study are available within the 
      article.
EDAT- 2022/07/21 06:00
MHDA- 2022/07/22 06:00
PMCR- 2022/07/13
CRDT- 2022/07/20 02:07
PHST- 2022/03/17 00:00 [received]
PHST- 2022/07/04 00:00 [accepted]
PHST- 2022/07/20 02:07 [entrez]
PHST- 2022/07/21 06:00 [pubmed]
PHST- 2022/07/22 06:00 [medline]
PHST- 2022/07/13 00:00 [pmc-release]
AID - 366792 [pii]
AID - 10.2147/COPD.S366792 [doi]
PST - epublish
SO  - Int J Chron Obstruct Pulmon Dis. 2022 Jul 13;17:1589-1600. doi: 
      10.2147/COPD.S366792. eCollection 2022.