PMID- 35857090 OWN - NLM STAT- MEDLINE DCOM- 20230412 LR - 20230412 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) VI - 273 IP - 3 DP - 2023 Apr TI - Eye movement indices as predictors of conversion to psychosis in individuals at clinical high risk. PG - 553-563 LID - 10.1007/s00406-022-01463-z [doi] AB - Eye movement abnormalities have been established as an "endophenotype" of schizophrenia. However, less is known about the possibility of these abnormalities as biomarkers for psychosis conversion among clinical high risk (CHR) populations. In the present study, 108 CHR individuals and 70 healthy controls (HC) underwent clinical assessments and eye-tracking tests, comprising fixation stability and free-viewing tasks. According to three-year follow-up outcomes, CHR participants were further stratified into CHR-converter (CHR-C; n = 21) and CHR-nonconverter (CHR-NC; n = 87) subgroups. Prediction models were constructed using Cox regression and logistic regression. The CHR-C group showed more saccades of the fixation stability test (no distractor) and a reduced saccade amplitude of the free-viewing test than HC. Moreover, the CHR-NC group exhibited excessive saccades and an increased saccade amplitude of the fixation stability test (no distractor; with distractor) compared with HC. Furthermore, two indices could effectively discriminate CHR-C from CHR-NC with an area under the receiver-operating characteristic (ROC) curve of 0.80, including the saccade number of the fixation stability test (no distractor) and the saccade amplitude of the free-viewing test. Combined with negative symptom scores of the Scale of Prodromal Symptoms, the area was 0.81. These findings support that eye movement alterations might emerge before the onset of clinically overt psychosis and could assist in predicting psychosis transition among CHR populations. CI - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. FAU - Zhang, Dan AU - Zhang D AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. FAU - Xu, Lihua AU - Xu L AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. FAU - Xie, Yuou AU - Xie Y AD - First Clinical Medical College of Nanjing Medical University, Nanjing, 211103, People's Republic of China. FAU - Tang, Xiaochen AU - Tang X AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. FAU - Hu, Yegang AU - Hu Y AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. FAU - Liu, Xu AU - Liu X AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. FAU - Wu, Guisen AU - Wu G AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. FAU - Qian, Zhenying AU - Qian Z AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. FAU - Tang, Yingying AU - Tang Y AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. FAU - Liu, Zhi AU - Liu Z AD - Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, 200444, People's Republic of China. AD - School of Communication and Information Engineering, Shanghai University, Shanghai, 200444, People's Republic of China. FAU - Chen, Tao AU - Chen T AD - Senior Research Fellow, Labor and Worklife Program, Harvard University, Cambridge, MA, USA. AD - Big Data Research Lab, University of Waterloo, Waterloo, ON, Canada. AD - Niacin (Shanghai) Technology Co., Ltd., Shanghai, People's Republic of China. FAU - Liu, HaiChun AU - Liu H AD - Department of Automation, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China. FAU - Zhang, Tianhong AU - Zhang T AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. zhang_tianhong@126.com. FAU - Wang, Jijun AU - Wang J AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China. jijunwang27@163.com. AD - CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, People's Republic of China. jijunwang27@163.com. AD - Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai, People's Republic of China. jijunwang27@163.com. LA - eng GR - 2016YFC1306800/Ministry of Science and Technology of China, National Key R&D Program of China/ GR - 81671332/National Natural Science Foundation of China/ GR - 81971251/National Natural Science Foundation of China/ GR - 81671329/National Natural Science Foundation of China/ GR - 81871050/National Natural Science Foundation of China/ GR - 62171269/National Natural Science Foundation of China/ GR - No. 2018SHZDZX01/Shanghai Municipal Science and Technology Major Project/ GR - (16JC1420200/Science and Technology Commission of Shanghai Municipality/ GR - 16ZR1430500/Science and Technology Commission of Shanghai Municipality/ GR - 19410710800/Science and Technology Commission of Shanghai Municipality/ GR - 19411969100/Science and Technology Commission of Shanghai Municipality/ GR - 19441907800/Science and Technology Commission of Shanghai Municipality/ GR - 20ZR1448600/Science and Technology Commission of Shanghai Municipality/ GR - 21S31903100/Science and Technology Commission of Shanghai Municipality/ GR - 202040361/Shanghai Municipal Health Commission/ GR - DLY201817/Clinical Research Center at Shanghai Jiao Tong University School of Medicine/ GR - ZH2018ZDB03/Shanghai Jiao Tong University Foundation/ GR - ZH2018QNB19/Shanghai Jiao Tong University Foundation/ GR - CRC2018ZD01/The Clinical Research Center at Shanghai Mental Health Center/ GR - CRC2018ZD04/The Clinical Research Center at Shanghai Mental Health Center/ GR - CRC2018YB01/The Clinical Research Center at Shanghai Mental Health Center/ GR - CRC2019ZD02/The Clinical Research Center at Shanghai Mental Health Center/ GR - 2019-zd01/Shanghai Mental Health Center/ GR - 21DZ2300400/"To the youth" Psychological class for middle school students/ PT - Journal Article DEP - 20220720 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 SB - IM MH - Humans MH - Eye Movements MH - *Psychotic Disorders/diagnosis MH - *Schizophrenia/diagnosis MH - Risk Factors MH - Saccades MH - Prodromal Symptoms OTO - NOTNLM OT - Eye movement OT - Schizophrenia OT - Transition OT - Ultra high risk EDAT- 2022/07/21 06:00 MHDA- 2023/04/12 06:42 CRDT- 2022/07/20 11:15 PHST- 2021/08/15 00:00 [received] PHST- 2022/06/27 00:00 [accepted] PHST- 2023/04/12 06:42 [medline] PHST- 2022/07/21 06:00 [pubmed] PHST- 2022/07/20 11:15 [entrez] AID - 10.1007/s00406-022-01463-z [pii] AID - 10.1007/s00406-022-01463-z [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2023 Apr;273(3):553-563. doi: 10.1007/s00406-022-01463-z. Epub 2022 Jul 20.