PMID- 35858474
OWN - NLM
STAT- MEDLINE
DCOM- 20220825
LR  - 20220825
IS  - 2047-4849 (Electronic)
IS  - 2047-4830 (Linking)
VI  - 10
IP  - 17
DP  - 2022 Aug 24
TI  - pH-Responsive hyaluronic acid-enveloped ZIF-8 nanoparticles for 
      anti-atherosclerosis therapy.
PG  - 4837-4847
LID - 10.1039/d2bm00603k [doi]
AB  - Nanomedicines represent new promising strategies for treating atherosclerosis 
      (AS), because they enhance drug bioavailability and have lower side effects. 
      Nevertheless, nanomedicines have several challenges with these advantages, 
      including a limited circulation life, lack of precise targeting, and insufficient 
      control of drug release. Accordingly, the development of drug delivery systems 
      (DDSs) with abilities to enhance the payload delivery to the AS plaque lesion and 
      to control drug release can boost the therapeutic efficacy and safety for AS 
      treatment. Herein, we employed a one-step self-assembly approach for effectively 
      encapsulating the anti-AS drug simvastatin (SIM) in zeolitic imidazolate 
      framework-8 (ZIF-8) (SIM/ZIF-8), and then coated it with hyaluronic acid (HA) to 
      fabricate the SIM/ZIF-8@HA nanoplatform. The resulting nanoplatform could 
      efficiently accumulate in plaque regions through the specific recognition between 
      HA and CD44. Meanwhile, the acid environment breaks down ZIF-8 to release SIM. 
      The in vitro and in vivo experiments demonstrated that SIM/ZIF-8@HA could inhibit 
      the proliferation of smooth muscle cells and have good biocompatibility. 
      Moreover, SIM/ZIF-8@HA can effectively suppress the development of AS plaques 
      without any considerable side effects in mice treatments. The findings revealed 
      that SIM/ZIF-8@HA may be a promising nanomedicine for safe and efficient anti-AS 
      applications.
FAU - Obaid, Essam Abdo Mohammed Saad
AU  - Obaid EAMS
AUID- ORCID: 0000-0002-2734-4028
AD  - Key Laboratory of Biorheological and Technology of Ministry of Education, State 
      and Local Joint Engineering Laboratory for Vascular Implants, Modern Life Science 
      Experiment Teaching Center at Bioengineering College of Chongqing University, 
      Chongqing 400030, China. wangyi@cqmu.edu.cn.
FAU - Wu, Shuai
AU  - Wu S
AUID- ORCID: 0000-0003-3071-439X
AD  - Key Laboratory of Biorheological and Technology of Ministry of Education, State 
      and Local Joint Engineering Laboratory for Vascular Implants, Modern Life Science 
      Experiment Teaching Center at Bioengineering College of Chongqing University, 
      Chongqing 400030, China. wangyi@cqmu.edu.cn.
FAU - Zhong, Yuan
AU  - Zhong Y
AD  - Key Laboratory of Biorheological and Technology of Ministry of Education, State 
      and Local Joint Engineering Laboratory for Vascular Implants, Modern Life Science 
      Experiment Teaching Center at Bioengineering College of Chongqing University, 
      Chongqing 400030, China. wangyi@cqmu.edu.cn.
FAU - Yan, Meng
AU  - Yan M
AD  - Key Laboratory of Biorheological and Technology of Ministry of Education, State 
      and Local Joint Engineering Laboratory for Vascular Implants, Modern Life Science 
      Experiment Teaching Center at Bioengineering College of Chongqing University, 
      Chongqing 400030, China. wangyi@cqmu.edu.cn.
FAU - Zhu, Li
AU  - Zhu L
AD  - Key Laboratory of Biorheological and Technology of Ministry of Education, State 
      and Local Joint Engineering Laboratory for Vascular Implants, Modern Life Science 
      Experiment Teaching Center at Bioengineering College of Chongqing University, 
      Chongqing 400030, China. wangyi@cqmu.edu.cn.
FAU - Li, Bibo
AU  - Li B
AD  - Department of Oncology, Chongqing People's Hospital, Chongqing 401147, China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Key Laboratory of Biorheological and Technology of Ministry of Education, State 
      and Local Joint Engineering Laboratory for Vascular Implants, Modern Life Science 
      Experiment Teaching Center at Bioengineering College of Chongqing University, 
      Chongqing 400030, China. wangyi@cqmu.edu.cn.
AD  - College of Basic Medical Sciences, Chongqing Medical University, Chongqing 
      400016, China.
FAU - Wu, Wei
AU  - Wu W
AUID- ORCID: 0000-0003-3900-5135
AD  - Key Laboratory of Biorheological and Technology of Ministry of Education, State 
      and Local Joint Engineering Laboratory for Vascular Implants, Modern Life Science 
      Experiment Teaching Center at Bioengineering College of Chongqing University, 
      Chongqing 400030, China. wangyi@cqmu.edu.cn.
FAU - Wang, Guixue
AU  - Wang G
AUID- ORCID: 0000-0002-9192-8757
AD  - Key Laboratory of Biorheological and Technology of Ministry of Education, State 
      and Local Joint Engineering Laboratory for Vascular Implants, Modern Life Science 
      Experiment Teaching Center at Bioengineering College of Chongqing University, 
      Chongqing 400030, China. wangyi@cqmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220824
PL  - England
TA  - Biomater Sci
JT  - Biomaterials science
JID - 101593571
RN  - 1318-02-1 (Zeolites)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Animals
MH  - Drug Delivery Systems
MH  - Hyaluronic Acid/pharmacology
MH  - Hydrogen-Ion Concentration
MH  - Mice
MH  - *Nanoparticles/therapeutic use
MH  - *Zeolites
EDAT- 2022/07/21 06:00
MHDA- 2022/08/26 06:00
CRDT- 2022/07/20 17:32
PHST- 2022/07/21 06:00 [pubmed]
PHST- 2022/08/26 06:00 [medline]
PHST- 2022/07/20 17:32 [entrez]
AID - 10.1039/d2bm00603k [doi]
PST - epublish
SO  - Biomater Sci. 2022 Aug 24;10(17):4837-4847. doi: 10.1039/d2bm00603k.