PMID- 35858996
OWN - NLM
STAT- MEDLINE
DCOM- 20220722
LR  - 20220929
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jul 20
TI  - Relationship between hyperhomocysteinemia and coexisting obesity with low 
      skeletal muscle mass in asymptomatic adult population.
PG  - 12439
LID - 10.1038/s41598-022-16401-1 [doi]
LID - 12439
AB  - The relationship between hyperhomocysteinemia (HHcy) and obesity with low 
      skeletal muscle mass (LMM) has not been established. We aim to assess the 
      association between HHcy and the coexistence of obesity and LMM in asymptomatic 
      adult population. We conducted a population-based cross-sectional study among 
      asymptomatic individuals who underwent measurements of plasma homocysteine and 
      body composition analysis. HHcy was defined as > 15 umol/L, obesity as body mass 
      index >/= 25 (kg/m(2)), and LMM as skeletal muscle index less than 2 SD below the 
      sex-specific mean of young adults. The participants were classified into 
      'control', 'obesity alone', 'LMM alone', and 'obesity with LMM'. Among 113,805 
      participants, the prevalence of HHcy was 8.3% in control, 8.7% in obesity alone, 
      10.0% in LMM alone, and 13.0% in obesity with LMM (p for trend < 0.001). In a 
      multivariable logistic regression analysis, the associations showed a positive 
      trend for HHcy along the groups from obesity alone, to LMM alone, and to obesity 
      with LMM. HHcy was independently associated with the presence of LMM alone 
      (adjusted odds ratio 1.186 [95% confidence interval 1.117-1.259]) and obesity 
      with LMM (1.424 [1.134-1.788]), respectively. This study demonstrated that HHcys 
      was more strongly associated with coexistence of obesity and LMM than either 
      condition alone in the adult population.
CI  - (c) 2022. The Author(s).
FAU - Yoo, Tae Kyung
AU  - Yoo TK
AD  - Department of Medicine, MetroWest Medical Center/Tufts University School of 
      Medicine, Framingham, MA, USA.
FAU - Rhim, Hye Chang
AU  - Rhim HC
AD  - Department of Medicine, MetroWest Medical Center/Tufts University School of 
      Medicine, Framingham, MA, USA.
FAU - Lee, Yong-Taek
AU  - Lee YT
AD  - Department of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, 
      Sungkyunkwan University School of Medicine, 29 Saemunanro, Jongno-gu, Seoul, 
      03181, Republic of Korea.
FAU - Yoon, Kyung Jae
AU  - Yoon KJ
AD  - Department of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, 
      Sungkyunkwan University School of Medicine, 29 Saemunanro, Jongno-gu, Seoul, 
      03181, Republic of Korea.
AD  - Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Republic of Korea.
FAU - Park, Chul-Hyun
AU  - Park CH
AD  - Department of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, 
      Sungkyunkwan University School of Medicine, 29 Saemunanro, Jongno-gu, Seoul, 
      03181, Republic of Korea. chpark0930@gmail.com.
AD  - Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Republic of Korea. chpark0930@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220720
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Female
MH  - Homocysteine
MH  - Humans
MH  - *Hyperhomocysteinemia/complications/epidemiology
MH  - Male
MH  - Muscle, Skeletal
MH  - Obesity/complications/epidemiology
MH  - Risk Factors
PMC - PMC9300668
COIS- The authors declare no competing interests.
EDAT- 2022/07/21 06:00
MHDA- 2022/07/23 06:00
PMCR- 2022/07/20
CRDT- 2022/07/20 23:46
PHST- 2022/01/21 00:00 [received]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/07/20 23:46 [entrez]
PHST- 2022/07/21 06:00 [pubmed]
PHST- 2022/07/23 06:00 [medline]
PHST- 2022/07/20 00:00 [pmc-release]
AID - 10.1038/s41598-022-16401-1 [pii]
AID - 16401 [pii]
AID - 10.1038/s41598-022-16401-1 [doi]
PST - epublish
SO  - Sci Rep. 2022 Jul 20;12(1):12439. doi: 10.1038/s41598-022-16401-1.