PMID- 35859403
OWN - NLM
STAT- MEDLINE
DCOM- 20220722
LR  - 20220722
IS  - 1998-3905 (Electronic)
IS  - 0970-4388 (Linking)
VI  - 40
IP  - 2
DP  - 2022 Apr-Jun
TI  - Correlation of caries occurrence in primary teeth using human leukocyte antigen 
      typing and maternal and physiochemical factors.
PG  - 124-131
LID - 10.4103/jisppd.jisppd_76_22 [doi]
AB  - BACKGROUND: Dental caries being the leading health issue worldwide has no 
      specific cure due to its multifactorial etiology and genetic susceptibility. 
      Hence, this paper attempted to correlate the clinical and hereditary factors 
      between mother and child, to predict the caries occurrence in child in future, 
      and thereby implement early preventive measures. AIM: The aim of the study was to 
      look for an association between maternal and child's human leukocyte antigen 
      (HLA)-DR4 levels and relate it with other physiochemical factors to assess caries 
      susceptibility in children. METHODOLOGY: Saliva samples were collected from 
      children who were in the age group of 0-6 years and their mothers by spitting 
      method and swab method. The clinical indicators such as Decayed, Missing, and 
      Filled Teeth, decayed, extraction needed, and filled teeth, salivary flow rate, 
      and pH were recorded by clinical evaluation. The Streptococcus mutans count was 
      measured by culture plate followed by colony count method, and the HLA-DR4 factor 
      was assessed using ELISA. RESULTS: The results revealed a statistically 
      significant correlation between the physiochemical factors of the mother and the 
      child. The genetic factor in which the HLA-DR4 caries indicator was checked also 
      has a strong association between the mother and the offspring. Thus, a strong 
      caries prediction formula was derived through which probability of caries 
      occurrence in the child could be determined prematurely. CONCLUSION: Thus, it can 
      be concluded that using the clinical and genetic factors, the caries prediction 
      can be done for the child and preventive protocol can be started before disease 
      occurrence.
FAU - Saikia, Shraddha
AU  - Saikia S
AD  - Department of Pediatric and Preventive Dentistry, I.T.S Dental College, 
      Ghaziabad, Uttar Pradesh, India.
FAU - Mathur, Shivani
AU  - Mathur S
AD  - Department of Pediatric and Preventive Dentistry, I.T.S Dental College, 
      Ghaziabad, Uttar Pradesh, India.
FAU - Malik, Manvi
AU  - Malik M
AD  - Department of Pediatric and Preventive Dentistry, I.T.S Dental College, 
      Ghaziabad, Uttar Pradesh, India.
FAU - Gulati, Nikita
AU  - Gulati N
AD  - Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S Dental 
      College, Ghaziabad, Uttar Pradesh, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Indian Soc Pedod Prev Dent
JT  - Journal of the Indian Society of Pedodontics and Preventive Dentistry
JID - 8710631
RN  - 0 (HLA-DR4 Antigen)
MH  - Child
MH  - Child, Preschool
MH  - DMF Index
MH  - *Dental Caries/epidemiology
MH  - *Dental Caries Susceptibility
MH  - Female
MH  - HLA-DR4 Antigen
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Saliva
MH  - Streptococcus mutans
MH  - Tooth, Deciduous
OTO - NOTNLM
OT  - Children
OT  - correlation
OT  - dental caries
OT  - human leukocyte antigen genotyping
OT  - mother
OT  - physiochemical factors
COIS- None
EDAT- 2022/07/22 06:00
MHDA- 2022/07/23 06:00
CRDT- 2022/07/21 01:43
PHST- 2022/07/21 01:43 [entrez]
PHST- 2022/07/22 06:00 [pubmed]
PHST- 2022/07/23 06:00 [medline]
AID - JIndianSocPedodPrevDent_2022_40_2_124_351051 [pii]
AID - 10.4103/jisppd.jisppd_76_22 [doi]
PST - ppublish
SO  - J Indian Soc Pedod Prev Dent. 2022 Apr-Jun;40(2):124-131. doi: 
      10.4103/jisppd.jisppd_76_22.