PMID- 35860295
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220722
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 16
DP  - 2022
TI  - Structure-Function Decoupling: A Novel Perspective for Understanding the 
      Radiation-Induced Brain Injury in Patients With Nasopharyngeal Carcinoma.
PG  - 915164
LID - 10.3389/fnins.2022.915164 [doi]
LID - 915164
AB  - Radiation-induced functional and structural brain alterations are well documented 
      in patients with nasopharyngeal carcinoma (NPC), followed by radiotherapy (RT); 
      however, alterations in structure-function coupling remain largely unknown. 
      Herein, we aimed to assess radiation-induced structure-function decoupling and 
      its importance in predicting radiation encephalopathy (RE). We included 62 
      patients with NPC (22 patients in the pre-RT cohort, 18 patients in the 
      post-RT-RE(+ve) cohort, and 22 patients in the post-RT-RE(-ve) cohort). A metric 
      of regional homogeneity (ReHo)/voxel-based morphometry (VBM) was used to detect 
      radiation-induced structure-function decoupling, which was then used as a feature 
      to construct a predictive model for RE. Compared with the pre-RT group, patients 
      in the post-RT group (which included post-RT-RE(+ve) and post-RT-RE(-ve)) showed 
      higher ReHo/VBM coupling values in the substantia nigra (SN), the putamen, and 
      the bilateral thalamus and lower values in the brain stem, the cerebellum, the 
      bilateral medial temporal lobes (MTLs), the bilateral insula, the right 
      precentral and postcentral gyri, the medial prefrontal cortex (MPFC), and the 
      left inferior parietal lobule (IPL). In the post-RT group, negative correlations 
      were observed between maximum dosage of RT (MDRT) to the ipsilateral temporal 
      lobe and ReHo/VBM values in the ipsilateral middle temporal gyrus (MTG). 
      Moreover, structure-function decoupling in the bilateral superior temporal gyrus 
      (STG), the bilateral precentral and postcentral gyri, the paracentral lobules, 
      the right precuneus and IPL, and the right MPFC exhibited excellent predictive 
      performance (accuracy = 88.0%) in identifying patients likely to develop RE. 
      These findings show that ReHo/VBM may be a novel effective imaging metric that 
      reflects the neural mechanism underlying RE in patients with NPC.
CI  - Copyright (c) 2022 Kang, Chen, Ding, Li, Gao, Liu and Zhang.
FAU - Kang, Ya-Fei
AU  - Kang YF
AD  - Shaanxi Provincial Key Research Center of Child Mental and Behavioral Health, 
      School of Psychology, Shaanxi Normal University, Xi'an, China.
FAU - Chen, Rui-Ting
AU  - Chen RT
AD  - Department of Radiology, Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Ding, Hao
AU  - Ding H
AD  - Department of Radiology, Affiliated Hospital of Guilin Medical University, 
      Guilin, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Li, Li
AU  - Li L
AD  - State Key Laboratory of Oncology in South China, Collaborative Innovation Center 
      for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
FAU - Gao, Jian-Ming
AU  - Gao JM
AD  - State Key Laboratory of Oncology in South China, Department of Radiation 
      Oncology, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen 
      University Cancer Center, Guangzhou, China.
FAU - Liu, Li-Zhi
AU  - Liu LZ
AD  - State Key Laboratory of Oncology in South China, Collaborative Innovation Center 
      for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
FAU - Zhang, You-Ming
AU  - Zhang YM
AD  - Department of Radiology, Xiangya Hospital, Central South University, Changsha, 
      China.
AD  - National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, 
      Central South University, Changsha, China.
LA  - eng
PT  - Journal Article
DEP - 20220704
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9289669
OTO - NOTNLM
OT  - ReHo/VBM
OT  - individual prediction
OT  - nasopharyngeal carcinoma
OT  - radiation encephalopathy
OT  - structure-function coupling
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/22 06:00
MHDA- 2022/07/22 06:01
PMCR- 2022/01/01
CRDT- 2022/07/21 02:28
PHST- 2022/04/07 00:00 [received]
PHST- 2022/06/09 00:00 [accepted]
PHST- 2022/07/21 02:28 [entrez]
PHST- 2022/07/22 06:00 [pubmed]
PHST- 2022/07/22 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2022.915164 [doi]
PST - epublish
SO  - Front Neurosci. 2022 Jul 4;16:915164. doi: 10.3389/fnins.2022.915164. eCollection 
      2022.