PMID- 35861756
OWN - NLM
STAT- MEDLINE
DCOM- 20221110
LR  - 20221110
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 26
IP  - 11
DP  - 2022 Nov
TI  - Relationship between chronic periodontitis and inflammatory cytokines in patients 
      undergoing maintenance hemodialysis.
PG  - 6699-6709
LID - 10.1007/s00784-022-04629-0 [doi]
AB  - OBJECTIVES: To investigate the correlation between serum and gingival crevicular 
      fluid (GCF) levels of inflammatory cytokines and the association with periodontal 
      parameters in patients with maintenance hemodialysis (MHD) and healthy control. 
      MATERIALS AND METHODS: Patients who were undergoing MHD were enrolled as the MHD 
      group. Healthy individuals who underwent oral examination were selected as the 
      control group after matching for the MHD group. All participants underwent a 
      full-mouth periodontal evaluation, and the levels of eight inflammatory 
      cytokines, including IL-1beta, IL-17, IL-6, IL-8, and tumor necrosis factor-alpha 
      (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-8 
      (MMP-8), and C-reactive protein (CRP), in the GCF and serum were measured. 
      RESULTS: A total of 63 MHD patients and 75 healthy persons were included. The 
      prevalence of moderate/severe periodontitis was significantly higher in the MHD 
      group than in the control group (88.9 vs. 66.7%, P < 0.05). The GCF levels of 
      CRP, TNF-alpha, MCP-1, and MMP-8 were higher in patients in the MHD group with 
      moderate/severe periodontitis than in the control group (P < 0.05). Serum CRP, 
      MCP-1, TNF-alpha, and MMP-8 levels were positively correlated with the GCF CRP levels 
      (P < 0.05). The GCF and serum CRP levels were positively correlated with the 
      periodontal clinical parameters (P < 0.05). CONCLUSIONS: Serum CRP, MCP-1, TNF-alpha, 
      and MMP-8 may relate with the GCF CRP levels. The GCF and serum CRP levels 
      correlated positively with the periodontal clinical parameters, including the 
      VPI, PPD, and CAL, indicating that CRP may play an important role between 
      periodontitis and ESRD. CLINICAL RELEVANCE: The present study indicated that GCF 
      and serum CRP levels correlated positively with the periodontal clinical 
      parameters, and the CRP levels may be selected as an indicator to evaluate the 
      severity of inflammation and the effectiveness, prognosis of periodontal 
      treatment in ESRD patients.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Lu, Haixia
AU  - Lu H
AD  - Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai 
      Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao 
      Tong University; National Center for Stomatology; National Clinical Research 
      Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit 
      of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical 
      Sciences, 639 Zhizaoju Road, Shanghai, China.
FAU - Wu, Hongyu
AU  - Wu H
AD  - Department of Endodontics, Shanghai Stomatological Hospital, Fudan University; 
      Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan 
      University, 356 Beijingdong Road, Shanghai, China.
FAU - Yang, Yuanmeng
AU  - Yang Y
AD  - Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai 
      Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao 
      Tong University; National Center for Stomatology; National Clinical Research 
      Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit 
      of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical 
      Sciences, 639 Zhizaoju Road, Shanghai, China.
FAU - Feng, Xiping
AU  - Feng X
AD  - Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai 
      Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao 
      Tong University; National Center for Stomatology; National Clinical Research 
      Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit 
      of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical 
      Sciences, 639 Zhizaoju Road, Shanghai, China.
FAU - Ma, Xiaoxin
AU  - Ma X
AD  - Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai 
      Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao 
      Tong University; National Center for Stomatology; National Clinical Research 
      Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit 
      of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical 
      Sciences, 639 Zhizaoju Road, Shanghai, China.
FAU - Xie, Yingxin
AU  - Xie Y
AD  - Department of Nephrology, Shanghai Ninth People's Hospital, College of 
      Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, 
      Shanghai, China.
FAU - Xie, Danshu
AU  - Xie D
AD  - Department of Nephrology, Shanghai Ninth People's Hospital, College of 
      Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, 
      Shanghai, China.
FAU - Wang, Wenji
AU  - Wang W
AD  - Department of Nephrology, Shanghai Ninth People's Hospital, College of 
      Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, 
      Shanghai, China.
FAU - Lo, Edward Chin Man
AU  - Lo ECM
AD  - Dental Public Health, Faculty of Dentistry, University of Hong Kong, 34 Hospital 
      Road, Hong Kong, China.
FAU - Ye, Wei
AU  - Ye W
AUID- ORCID: 0000-0001-8001-2834
AD  - Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai 
      Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao 
      Tong University; National Center for Stomatology; National Clinical Research 
      Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit 
      of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical 
      Sciences, 639 Zhizaoju Road, Shanghai, China. jyyewei@163.com.
LA  - eng
GR  - 2019-I2M-5-037/CAMS Innovation Fund for Medical Sciences/
GR  - 19MC1910600/Shanghai Clinical Research Center for Oral Diseases/
GR  - 201918069/Clinical Research Program of ninth People's Hospital, Shanghai JiaoTong 
      University School of Medicine/
GR  - 201940041/General Project of the Shanghai Municipal Health Committee/
GR  - SHDC2020CR5015/Clinical Research Plan of SHDC/
PT  - Journal Article
DEP - 20220721
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
MH  - Humans
MH  - *Chronic Periodontitis/therapy
MH  - Matrix Metalloproteinase 8
MH  - Cytokines
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - Gingival Crevicular Fluid/chemistry
MH  - C-Reactive Protein/analysis
MH  - Renal Dialysis
MH  - *Kidney Failure, Chronic/therapy
OTO - NOTNLM
OT  - End-stage renal disease
OT  - Gingival crevicular fluid
OT  - Inflammatory cytokines
OT  - Maintenance hemodialysis
OT  - Periodontitis
EDAT- 2022/07/22 06:00
MHDA- 2022/11/11 06:00
CRDT- 2022/07/21 11:03
PHST- 2022/03/18 00:00 [received]
PHST- 2022/07/12 00:00 [accepted]
PHST- 2022/07/22 06:00 [pubmed]
PHST- 2022/11/11 06:00 [medline]
PHST- 2022/07/21 11:03 [entrez]
AID - 10.1007/s00784-022-04629-0 [pii]
AID - 10.1007/s00784-022-04629-0 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2022 Nov;26(11):6699-6709. doi: 10.1007/s00784-022-04629-0. 
      Epub 2022 Jul 21.