PMID- 35863207
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220902
IS  - 1873-5150 (Electronic)
IS  - 0887-8994 (Linking)
VI  - 134
DP  - 2022 Sep
TI  - HLA-DRB1 *1502 Is Associated With Anti-N-Methyl-D-aspartate Receptor Encephalitis 
      in Thai Children.
PG  - 93-99
LID - S0887-8994(22)00119-9 [pii]
LID - 10.1016/j.pediatrneurol.2022.06.014 [doi]
AB  - BACKGROUND: Anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is one 
      of the most common types of autoimmune encephalitis. Most patients have no 
      apparent immunologic triggers, which suggests a genetic predisposition. This 
      study was conducted to identify human leukocyte antigen (HLA) class II alleles 
      associated with anti-NMDARE in Thai children. METHODS: This case-control study 
      enrolled patients younger than 18 years who were diagnosed with anti-NMDARE 
      between January 2010 and December 2020. A "good outcome" was determined as a 
      patient with a modified Rankin scale score of less than 2 at any follow-up visit. 
      HLA genotypes were determined at four-digit alleles using reverse 
      sequence-specific oligonucleotide probe hybridization. The HLA class II allele 
      frequency in patients was compared with that in a database of 101 healthy control 
      Thai children. RESULTS: Thirty-four patients were enrolled with a mean age of 
      12.8 +/- 5.6 years (females 85.3%). The HLA-DRB1 *1502 allele frequency was 
      significantly higher in patients than in controls (odds ratio, 2.32; 95% 
      confidence interval, 1.11-4.8, P = 0.023). A good outcome was noted in 14 of 14 
      (100%) HLA-DRB1 *1502-positive patients (median time to a good outcome, 6 months) 
      and 14 of 17 (82.3%) HLA-DRB1 *1502-negative patients (median time to a good 
      outcome, 3 months). Two (11.8%) HLA-DRB1 *1502-positive patients had one relapse 
      each, and six (35.3%) HLA-DRB1 *1502-negative patients had one to three relapses. 
      CONCLUSIONS: HLA-DRB1 *1502 was significantly associated with anti-NMDARE in our 
      patients. Most patients had good outcomes. HLA-DRB1 *1502-positive patients tended 
      to require a longer time to achieve a good outcome but had less frequent relapses 
      than HLA-DRB1 *1502-negative patients.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Anurat, Kingthong
AU  - Anurat K
AD  - Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, 
      Mahidol University, Samut Prakan, Thailand.
FAU - Watcharakuldilok, Piangor
AU  - Watcharakuldilok P
AD  - Department of Pediatrics, Buriram Hospital, Buriram, Thailand.
FAU - Sakpichaisakul, Kullasate
AU  - Sakpichaisakul K
AD  - Department of Pediatrics, Queen Sirikit National Institute of Child Health, 
      Ministry of Public Health, College of Medicine, Rangsit University, Bangkok, 
      Thailand.
FAU - Khongkhatithum, Chaiyos
AU  - Khongkhatithum C
AD  - Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Mahasirimongkol, Surakameth
AU  - Mahasirimongkol S
AD  - Department of Medical Sciences, Medical Genetics Section, National Institute of 
      Health, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Kunhapan, Punna
AU  - Kunhapan P
AD  - Department of Medical Sciences, Medical Genetics Section, National Institute of 
      Health, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Inunchot, Wimala
AU  - Inunchot W
AD  - Department of Medical Sciences, Medical Genetics Section, National Institute of 
      Health, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Wattanapokayakit, Sukanya
AU  - Wattanapokayakit S
AD  - Department of Medical Sciences, Medical Genetics Section, National Institute of 
      Health, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Munggaranonchai, Orathai
AU  - Munggaranonchai O
AD  - Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Thampratankul, Lunliya
AU  - Thampratankul L
AD  - Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand. Electronic address: lunliya.tha@mahidol.ac.th.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220626
PL  - United States
TA  - Pediatr Neurol
JT  - Pediatric neurology
JID - 8508183
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - *Anti-N-Methyl-D-Aspartate Receptor Encephalitis/genetics
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Neoplasm Recurrence, Local
MH  - Thailand
OTO - NOTNLM
OT  - Anti-NMDA receptor encephalitis
OT  - Genetic predisposition
OT  - HLA class II
OT  - HLA-DRB1 *1502
OT  - Thai children
EDAT- 2022/07/22 06:00
MHDA- 2022/08/17 06:00
CRDT- 2022/07/21 18:23
PHST- 2022/01/10 00:00 [received]
PHST- 2022/06/14 00:00 [revised]
PHST- 2022/06/15 00:00 [accepted]
PHST- 2022/07/22 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/07/21 18:23 [entrez]
AID - S0887-8994(22)00119-9 [pii]
AID - 10.1016/j.pediatrneurol.2022.06.014 [doi]
PST - ppublish
SO  - Pediatr Neurol. 2022 Sep;134:93-99. doi: 10.1016/j.pediatrneurol.2022.06.014. 
      Epub 2022 Jun 26.