PMID- 35863418 OWN - NLM STAT- MEDLINE DCOM- 20220928 LR - 20220928 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 307 IP - Pt 1 DP - 2022 Nov TI - Association of single and multiple prefluoroalkyl substances exposure with preterm birth: Results from a Chinese birth cohort study. PG - 135741 LID - S0045-6535(22)02234-2 [pii] LID - 10.1016/j.chemosphere.2022.135741 [doi] AB - BACKGROUND: Perfluoroalkyl substances (PFASs) are persistent organic pollutants that may lead the adverse birth outcomes, including preterm birth (PTB). However, previous studies have reported inconsistent results on the association between PFASs and PTB, and lack of the epidemiological evidence regarding the effect of PFASs mixture on PTB. This study aimed to explore association of individual and multiple exposure to PFASs with PTB. METHODS: The study subjects were consisted of 1341 pregnant women from Guangxi Zhuang Birth Cohort in Guangxi, China, from June 2015 to April 2019. Nine PFASs concentrations in the maternal serum were examined by ultrahigh liquid performance chromatography-tandem mass spectrometry, and the gestational weeks were obtained from medical records. We applied binary logistics regression model to explore correlation between individual PFAS and PTB and inspected the combined effect of PFASs mixture on PTB by applying Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) regression models. RESULTS: In adjusted logistics regression model, perfluorooctane sulfonate (PFOS), perfluoroheptanoic acid (PFHpA), perfluorobutanesulfonic acid (PFBS), summation operatorperfluorinated sulfonic acids (PFSA), and summation operatorPFASs were positively associated with the risk of PTB. In contrast, perfluoroundecanoic acid (PFUnA), perfluorohexane sulfonate (PFHxS), and perfluorooctanoic acid (PFOA) were negatively associated with the risk of PTB. These associations of n PFOS and PFHpA with PTB were found to be more pronounced in male infants. Restricted cubic splines (RCSs) showed an inverse U-shaped relationship between PFBS and PTB. Analysis from BKMR model showed a positive association between PFASs mixture and PTB, and no evidence of interactions among the nine PFASs were detected. Additionally, PFHpA, PFOS, and PFBS were identified as the main contributors for the effect of PFASs mixture on increasing the risk of PTB by BKMR and WQS models. CONCLUSION: Prenatal exposure to higher levels of PFASs mixture was associated with higher risk of PTB. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Liao, Qian AU - Liao Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Tang, Peng AU - Tang P AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Song, Yanye AU - Song Y AD - The Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, Guangxi, China. FAU - Liu, Bihu AU - Liu B AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Huang, Huishen AU - Huang H AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Liang, Jun AU - Liang J AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Lin, Mengrui AU - Lin M AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Shao, Yantao AU - Shao Y AD - The Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, Guangxi, China. FAU - Liu, Shun AU - Liu S AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Pan, Dongxiang AU - Pan D AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. Electronic address: gxpandongxiang@163.com. FAU - Huang, Dongping AU - Huang D AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. Electronic address: dongpinghuang@gxmu.edu.cn. FAU - Qiu, Xiaoqiang AU - Qiu X AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. Electronic address: xqqiu9999@163.com. LA - eng PT - Journal Article DEP - 20220718 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Alkanesulfonates) RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 0 (Sulfonic Acids) RN - 0 (perfluorobutanesulfonic acid) RN - 9H2MAI21CL (perfluorooctane sulfonic acid) SB - IM MH - Alkanesulfonates MH - *Alkanesulfonic Acids MH - Bayes Theorem MH - Birth Cohort MH - China/epidemiology MH - Cohort Studies MH - *Environmental Pollutants MH - Female MH - *Fluorocarbons/toxicity MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - Persistent Organic Pollutants MH - Pregnancy MH - *Premature Birth/chemically induced/epidemiology MH - Sulfonic Acids OTO - NOTNLM OT - Bayesian kernel machine regression OT - Guangxi Zhuang birth cohort OT - Perfluoroalkyl substances OT - Preterm birth OT - Weighted quantile sum regression COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/07/22 06:00 MHDA- 2022/09/28 06:00 CRDT- 2022/07/21 19:32 PHST- 2022/03/09 00:00 [received] PHST- 2022/07/12 00:00 [revised] PHST- 2022/07/13 00:00 [accepted] PHST- 2022/07/22 06:00 [pubmed] PHST- 2022/09/28 06:00 [medline] PHST- 2022/07/21 19:32 [entrez] AID - S0045-6535(22)02234-2 [pii] AID - 10.1016/j.chemosphere.2022.135741 [doi] PST - ppublish SO - Chemosphere. 2022 Nov;307(Pt 1):135741. doi: 10.1016/j.chemosphere.2022.135741. Epub 2022 Jul 18.