PMID- 35864782
OWN - NLM
STAT- MEDLINE
DCOM- 20220725
LR  - 20220810
IS  - 1947-6043 (Electronic)
IS  - 1947-6035 (Print)
IS  - 1947-6035 (Linking)
VI  - 13
IP  - 3
DP  - 2022 Jul-Sep
TI  - Time to Achieving Clinically Significant Outcomes After Meniscal Allograft 
      Transplantation.
PG  - 19476035221102568
LID - 10.1177/19476035221102568 [doi]
LID - 19476035221102568
AB  - PURPOSE: To determine the time to achieving minimal clinically important 
      difference (MCID) and patient acceptable symptomatic state (PASS) for commonly 
      administered patient-reported outcome (PRO) measures and risk factors affecting 
      achievement of clinically significant outcomes in patients undergoing meniscal 
      allograft transplantation (MAT). METHODS: A prospectively maintained MAT registry 
      was retrospectively reviewed from April 2014 to May 2019. Patients who underwent 
      revision MAT or did not complete preoperative PROs or one post operative time 
      point were excluded. Patients who underwent concomitant procedures were included 
      in the analysis. PROs were administered preoperatively and at 6 months, 1 year, 
      and 2 years postoperatively. Previously defined MCID and PASS thresholds were 
      utilized and Kaplan-Meier survival curve analysis with interval censoring was 
      used to calculate the cumulative percentages of MCID and PASS achievement at each 
      follow-up time interval (5-7, 11-13, and 23-25 months). RESULTS: Eighty patients 
      (age: 28.35 +/- 9.76, 50% male) who completed preoperative, 6-month (n = 69, 86% 
      compliance), and 1-year (n = 76, 95% compliance) PROs were included. The majority 
      of patients (>50%) achieved MCID and PASS on most included PROs. Workers' 
      compensation status was found to significantly delay achievement of MCID and PASS 
      on all PROs except for PASS on Knee Injury and Osteoarthritis Outcome Score 
      (KOOS) quality of life (QoL). Higher body mass index (BMI) significantly delayed 
      time to achieving MCID on KOOS Pain and activities of daily living (ADL), as well 
      as PASS on KOOS Symptoms and KOOS QoL. CONCLUSION: This study suggests that the 
      majority of patients have clinically significant improvements in pain and 
      function after MAT, with more than 50% of patients experiencing clinically 
      significant improvement within the first postoperative year. Workers' 
      compensation status and high BMI may prolong time to achievement of MCID and PASS 
      after MAT.
FAU - Huddleston, Hailey P
AU  - Huddleston HP
AD  - Rush University Medical Center, Chicago, IL, USA.
FAU - Polce, Evan M
AU  - Polce EM
AD  - Rush University Medical Center, Chicago, IL, USA.
FAU - Gilat, Ron
AU  - Gilat R
AD  - Rush University Medical Center, Chicago, IL, USA.
FAU - Mehta, Nabil
AU  - Mehta N
AUID- ORCID: 0000-0002-7255-4569
AD  - Rush University Medical Center, Chicago, IL, USA.
FAU - Alzein, Mohamad
AU  - Alzein M
AD  - Rush University Medical Center, Chicago, IL, USA.
FAU - Dandu, Navya
AU  - Dandu N
AUID- ORCID: 0000-0003-2410-7462
AD  - Rush University Medical Center, Chicago, IL, USA.
FAU - Parvaresh, Kevin C
AU  - Parvaresh KC
AD  - Rush University Medical Center, Chicago, IL, USA.
FAU - Cole, Brian J
AU  - Cole BJ
AD  - Rush University Medical Center, Chicago, IL, USA.
FAU - Yanke, Adam B
AU  - Yanke AB
AUID- ORCID: 0000-0002-9601-4217
AD  - Rush University Medical Center, Chicago, IL, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cartilage
JT  - Cartilage
JID - 101518378
SB  - IM
MH  - *Activities of Daily Living
MH  - Adolescent
MH  - Adult
MH  - Allografts
MH  - Female
MH  - Humans
MH  - Male
MH  - Pain
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC9310214
OTO - NOTNLM
OT  - allograft
OT  - knee
OT  - meniscal transplantation
OT  - meniscus
OT  - meniscus transplantation
OT  - procedures
OT  - tissue
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2022/07/23 06:00
MHDA- 2022/07/26 06:00
PMCR- 2022/07/21
CRDT- 2022/07/22 01:53
PHST- 2022/07/22 01:53 [entrez]
PHST- 2022/07/23 06:00 [pubmed]
PHST- 2022/07/26 06:00 [medline]
PHST- 2022/07/21 00:00 [pmc-release]
AID - 10.1177_19476035221102568 [pii]
AID - 10.1177/19476035221102568 [doi]
PST - ppublish
SO  - Cartilage. 2022 Jul-Sep;13(3):19476035221102568. doi: 10.1177/19476035221102568.