PMID- 35868019
OWN - NLM
STAT- MEDLINE
DCOM- 20221111
LR  - 20230120
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Print)
IS  - 1936-0851 (Linking)
VI  - 16
IP  - 8
DP  - 2022 Aug 23
TI  - Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized 
      at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters.
PG  - 13183-13198
LID - 10.1021/acsnano.2c06406 [doi]
AB  - The importance of neurotransmitter sensing in the diagnosis and treatment of many 
      psychological illnesses and neurodegenerative diseases is non-negotiable. For 
      electrochemical sensors to become widespread and accurate, a long journey must be 
      undertaken for each device, from understanding the materials at the molecular 
      level to real applications in biological fluids. We report a modification of 
      diamondized boron-doped carbon nanowalls (BCNWs) with an electropolymerized 
      polydopamine/polyzwitterion (PDA|PZ) coating revealing tunable mechanical and 
      electrochemical properties. Zwitterions are codeposited with PDA and 
      noncovalently incorporated into a structure. This approach causes a specific 
      separation of the diffusion fields generated by each nanowall during 
      electrochemical reactions, thus increasing the contribution of the steady-state 
      currents in the amperometric response. This phenomenon has a profound effect on 
      the sensing properties, leading to a 4-fold enhancement of the sensitivity (3.1 
      to 14.3 muA cm(-2) muM(-1)) and a 5-fold decrease of the limit of detection (505 to 
      89 nM) in comparison to the pristine BCNWs. Moreover, as a result of the 
      antifouling capabilities of the incorporated zwitterions, this enhancement is 
      preserved in bovine serum albumin (BSA) with a high protein concentration. The 
      presence of zwitterion facilitates the transport of dopamine in the direction of 
      the electrode by intermolecular interactions such as cation-pi and hydrogen bonds. 
      On the other hand, polydopamine units attached to the surface form molecular 
      pockets driven by hydrogen bonds and pi-pi interactions. As a result, the 
      intermediate state of dopamine-analyte oxidation is stabilized, leading to the 
      enhancement of the sensing properties.
FAU - Olejnik, Adrian
AU  - Olejnik A
AD  - Department of Metrology and Optoelectronics, Faculty of Electronics, 
      Telecommunications and Informatics, Gdansk University of Technology, Narutowicza 
      11/12 St., 80-233 Gdansk, Poland.
AD  - Centre for Plasma and Laser Engineering, The Szewalski Institute of Fluid-Flow 
      Machinery, Polish Academy of Sciences, Fiszera 14 St., 80-231 Gdansk, Poland.
FAU - Ficek, Mateusz
AU  - Ficek M
AUID- ORCID: 0000-0003-2334-9697
AD  - Department of Metrology and Optoelectronics, Faculty of Electronics, 
      Telecommunications and Informatics, Gdansk University of Technology, Narutowicza 
      11/12 St., 80-233 Gdansk, Poland.
FAU - Szkodo, Marek
AU  - Szkodo M
AD  - Institute of Manufacturing and Materials Technology, Faculty of Mechanical 
      Engineering and Ship Technology, Gdansk University of Technology, Narutowicza 
      11/12 St., 80-233 Gdansk, Poland.
FAU - Stanislawska, Alicja
AU  - Stanislawska A
AD  - Institute of Manufacturing and Materials Technology, Faculty of Mechanical 
      Engineering and Ship Technology, Gdansk University of Technology, Narutowicza 
      11/12 St., 80-233 Gdansk, Poland.
FAU - Karczewski, Jakub
AU  - Karczewski J
AD  - Institute of Nanotechnology and Materials Engineering and Advanced Materials 
      Center, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, 
      Poland.
FAU - Ryl, Jacek
AU  - Ryl J
AUID- ORCID: 0000-0002-0247-3851
AD  - Institute of Nanotechnology and Materials Engineering and Advanced Materials 
      Center, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, 
      Poland.
FAU - Dolega, Anna
AU  - Dolega A
AUID- ORCID: 0000-0003-0509-2285
AD  - Department of Inorganic Chemistry, Faculty of Chemistry, Gdansk University of 
      Technology, Narutowicza 11/12 St., 80-233 Gdansk, Poland.
FAU - Siuzdak, Katarzyna
AU  - Siuzdak K
AUID- ORCID: 0000-0001-7434-6408
AD  - Centre for Plasma and Laser Engineering, The Szewalski Institute of Fluid-Flow 
      Machinery, Polish Academy of Sciences, Fiszera 14 St., 80-231 Gdansk, Poland.
FAU - Bogdanowicz, Robert
AU  - Bogdanowicz R
AUID- ORCID: 0000-0002-7543-2620
AD  - Department of Metrology and Optoelectronics, Faculty of Electronics, 
      Telecommunications and Informatics, Gdansk University of Technology, Narutowicza 
      11/12 St., 80-233 Gdansk, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220722
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - VTD58H1Z2X (Dopamine)
RN  - 7440-44-0 (Carbon)
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - *Dopamine
MH  - *Carbon/chemistry
MH  - Electrochemical Techniques
MH  - Electrodes
MH  - Neurotransmitter Agents
PMC - PMC9413423
OTO - NOTNLM
OT  - carbon nanowalls
OT  - coelectropolymerization
OT  - diffusion fields
OT  - nanoindentation
OT  - polydopamine
OT  - sensing
OT  - zwitterions
COIS- The authors declare no competing financial interest.
EDAT- 2022/07/23 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/08/26
CRDT- 2022/07/22 16:53
PHST- 2022/07/23 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/07/22 16:53 [entrez]
PHST- 2022/08/26 00:00 [pmc-release]
AID - 10.1021/acsnano.2c06406 [doi]
PST - ppublish
SO  - ACS Nano. 2022 Aug 23;16(8):13183-13198. doi: 10.1021/acsnano.2c06406. Epub 2022 
      Jul 22.