PMID- 35868542
OWN - NLM
STAT- MEDLINE
DCOM- 20220809
LR  - 20220817
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 206
DP  - 2022 Sep
TI  - Long-term caloric restriction ameliorates T cell immunosenescence in mice.
PG  - 111710
LID - S0047-6374(22)00092-6 [pii]
LID - 10.1016/j.mad.2022.111710 [doi]
AB  - Aging is associated with a decrease in the function of the immune system, a 
      phenomenon known as immunosenescence, which results in reduced resistance to 
      infection. Caloric restriction (CR) is known to prolong lifespan and to regulate 
      immune function. However, whether and how CR affects immunosenescence remains 
      unclear. Here, we evaluated the effect of long- and short-term CR on 
      immunosenescence by subjecting wild-type mice to CR between 6 and 18 months of 
      age or between 17 and 18 months of age, respectively. Compared with a normal diet 
      or short-term CR, long-term CR induced marked or complete attenuation of 
      age-related decreases in the frequency of spleen NK cells and NKT cells; naive 
      CD4(+) and CD8(+) T cells; and cytokine- and granzyme B-secreting T cells. In 
      contrast, both long- and short-term CR significantly suppressed age-related 
      upregulation of the T cell exhaustion markers PD-1, Tim-3, and KLRG1, as well as 
      the transcription factors NR4A1 and TOX, which regulate the expression of genes 
      associated with the T cell exhaustion phenotype. These results suggest that CR 
      might suppress age-associated immunosenescence by regulating the expression of 
      transcription factors and target genes that control T cell exhaustion.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Asami, Takuya
AU  - Asami T
AD  - Department of Bioscience and Biotechnology, Graduate School of Agriculture, 
      Shinshu University, Minamiminowa, Nagano 399-4598, Japan.
FAU - Endo, Katsunori
AU  - Endo K
AD  - Department of Bioscience and Biotechnology, Graduate School of Agriculture, 
      Shinshu University, Minamiminowa, Nagano 399-4598, Japan.
FAU - Matsui, Rina
AU  - Matsui R
AD  - Department of Bioscience and Biotechnology, Graduate School of Agriculture, 
      Shinshu University, Minamiminowa, Nagano 399-4598, Japan.
FAU - Sawa, Toko
AU  - Sawa T
AD  - Department of Bioscience and Biotechnology, Graduate School of Agriculture, 
      Shinshu University, Minamiminowa, Nagano 399-4598, Japan.
FAU - Tanaka, Yuna
AU  - Tanaka Y
AD  - Department of Bioscience and Biotechnology, Graduate School of Agriculture, 
      Shinshu University, Minamiminowa, Nagano 399-4598, Japan.
FAU - Saiki, Takeru
AU  - Saiki T
AD  - Department of Bioscience and Biotechnology, Graduate School of Agriculture, 
      Shinshu University, Minamiminowa, Nagano 399-4598, Japan.
FAU - Tanba, Naotaka
AU  - Tanba N
AD  - Department of Bioscience and Biotechnology, Graduate School of Agriculture, 
      Shinshu University, Minamiminowa, Nagano 399-4598, Japan.
FAU - Haga, Hadsuki
AU  - Haga H
AD  - Department of Bioscience and Biotechnology, Graduate School of Agriculture, 
      Shinshu University, Minamiminowa, Nagano 399-4598, Japan.
FAU - Tanaka, Sachi
AU  - Tanaka S
AD  - Department of Bioscience and Biotechnology, Graduate School of Agriculture, 
      Shinshu University, Minamiminowa, Nagano 399-4598, Japan. Electronic address: 
      tanakasa@shinshu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220720
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - CD8-Positive T-Lymphocytes
MH  - Caloric Restriction
MH  - *Immunosenescence
MH  - Mice
MH  - Transcription Factors
OTO - NOTNLM
OT  - Aging
OT  - Caloric restriction
OT  - Immunosenescence
OT  - T cell exhaustion
EDAT- 2022/07/23 06:00
MHDA- 2022/08/10 06:00
CRDT- 2022/07/22 19:33
PHST- 2022/03/20 00:00 [received]
PHST- 2022/06/17 00:00 [revised]
PHST- 2022/07/18 00:00 [accepted]
PHST- 2022/07/23 06:00 [pubmed]
PHST- 2022/08/10 06:00 [medline]
PHST- 2022/07/22 19:33 [entrez]
AID - S0047-6374(22)00092-6 [pii]
AID - 10.1016/j.mad.2022.111710 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2022 Sep;206:111710. doi: 10.1016/j.mad.2022.111710. Epub 2022 
      Jul 20.