PMID- 35868762
OWN - NLM
STAT- MEDLINE
DCOM- 20220726
LR  - 20220726
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 294
DP  - 2022 Oct 15
TI  - Strategies for sustained release of heparin: A review.
PG  - 119793
LID - S0144-8617(22)00698-1 [pii]
LID - 10.1016/j.carbpol.2022.119793 [doi]
AB  - Heparin, a sulfate-containing linear polysaccharide, has proven preclinical and 
      clinical efficacy for a variety of disorders. Heparin, including unfractionated 
      heparin (UFH), low-molecular-weight heparin (LMWH), and 
      ultra-low-molecular-weight heparin (ULMWH), is administered systematically, in 
      the form of a solution in the clinic. However, it is eliminated quickly, due to 
      its short half-life, especially in the case of UFH and LMWH. Frequent 
      administration is required to ensure its therapeutic efficacy, leading to poor 
      patient compliance. Moreover, heparin is used to coat blood-contacting medical 
      devices to avoid thrombosis through physical interaction. However, the short-term 
      durability of heparin on the surface of the stent limits its further application. 
      Various advanced sustained-release strategies have been used to prolong its 
      half-life in vivo as preparation technologies have improved. Herein, we briefly 
      introduce the pharmacological activity and mechanisms of action of heparin. In 
      addition, the strategies for sustained release of heparin are comprehensively 
      summarized.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Yang, Xuewen
AU  - Yang X
AD  - School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, Jiangsu Province, 
      226001, China.
FAU - Wang, Qiuxiang
AU  - Wang Q
AD  - School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, Jiangsu Province, 
      226001, China.
FAU - Zhang, Aiwen
AU  - Zhang A
AD  - School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, Jiangsu Province, 
      226001, China.
FAU - Shao, Xinyao
AU  - Shao X
AD  - School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, Jiangsu Province, 
      226001, China.
FAU - Liu, Tianqing
AU  - Liu T
AD  - NICM Health Research Institute, Western Sydney University, Westmead, NSW 2145, 
      Australia.
FAU - Tang, Bo
AU  - Tang B
AD  - School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, Jiangsu Province, 
      226001, China. Electronic address: tangbo@ntu.edu.cn.
FAU - Fang, Guihua
AU  - Fang G
AD  - School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, Jiangsu Province, 
      226001, China. Electronic address: fangguihua@ntu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220630
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Anticoagulants)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/pharmacology/therapeutic use
MH  - Delayed-Action Preparations
MH  - *Heparin/therapeutic use
MH  - Heparin, Low-Molecular-Weight/pharmacology
MH  - Humans
MH  - *Thrombosis
OTO - NOTNLM
OT  - Heparin
OT  - Pharmacological activity
OT  - Sustained-release strategies
EDAT- 2022/07/23 06:00
MHDA- 2022/07/27 06:00
CRDT- 2022/07/22 21:05
PHST- 2022/04/01 00:00 [received]
PHST- 2022/06/18 00:00 [revised]
PHST- 2022/06/25 00:00 [accepted]
PHST- 2022/07/22 21:05 [entrez]
PHST- 2022/07/23 06:00 [pubmed]
PHST- 2022/07/27 06:00 [medline]
AID - S0144-8617(22)00698-1 [pii]
AID - 10.1016/j.carbpol.2022.119793 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2022 Oct 15;294:119793. doi: 10.1016/j.carbpol.2022.119793. Epub 
      2022 Jun 30.