PMID- 35868966
OWN - NLM
STAT- MEDLINE
DCOM- 20220928
LR  - 20230308
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 31
IP  - 10
DP  - 2022 Oct
TI  - Determining Underlying Mechanisms of Early Vascular Ageing by Clustered Analysis: 
      The African-PREDICT Study.
PG  - 1376-1384
LID - S1443-9506(22)00270-0 [pii]
LID - 10.1016/j.hlc.2022.05.042 [doi]
AB  - OBJECTIVE: Identifying individuals at increased risk of early vascular ageing 
      (EVA) is paramount to inform intervention and prevention strategies and curb the 
      increasing burden of cardiovascular disease. METHODS: We stratified and 
      phenotyped pre-screened young apparently healthy South African adults (20-30 yrs) 
      (n=1,041) into vascular ageing profile groups based on carotid femoral pulse wave 
      velocity (cfPWV) percentiles (healthy vascular ageing [HVA]; average vascular 
      ageing [AVA] and EVA). We further compared various anthropometric, cardiovascular 
      (CV), oxidative stress and lifestyle risk factors and determined factor scores to 
      explore associations between CV measures and factor clusters to explore 
      associations in those at risk of EVA. RESULTS: Young adults in the EVA group 
      displayed marked phenotypic characteristics in terms of anthropometry, CV, and 
      lifestyle risk factors, even though cfPWV were within healthy ranges. Blood 
      pressure (brachial and central) and cfPWV were all incrementally higher across 
      all three vascular ageing groups (p-trend </=0.011). Hypertension, lifestyle risk 
      factors such as self-reported smoking and alcohol consumption were all highest in 
      the EVA group (p-trend </=0.046). Additionally, in the EVA group only, cfPWV (adj. 
      R(2)=0.028; beta=0.171; p=0.042) associated positively with Factor 2 (oxidative 
      stress and antioxidant capacity). No associations existed between Factor 1 (basic 
      lipids) and any anthropometric or CV measures (p>0.050). CONCLUSION: Young adults 
      with higher cfPWV presented with a less favourable vascular profile and more 
      unhealthy lifestyle behaviours compared to groups with lower cfPWV. In the EVA 
      group, cfPWV positively associated with a cluster of oxidative stress and 
      antioxidant capacity. Early lifestyle behaviours may have the ability to modify 
      the balance between oxidants and antioxidants, potentially contributing to early 
      onset arterial stiffness.
CI  - Copyright (c) 2022 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      Published by Elsevier B.V. All rights reserved.
FAU - Craig, Ashleigh
AU  - Craig A
AD  - Hypertension in Africa Research Team (HART); North-West University, 
      Potchefstroom, South Africa.
FAU - Smith, Wayne
AU  - Smith W
AD  - Hypertension in Africa Research Team (HART); North-West University, 
      Potchefstroom, South Africa; MRC Research Unit for Hypertension and 
      Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
FAU - Mels, Catharina M C
AU  - Mels CMC
AD  - Hypertension in Africa Research Team (HART); North-West University, 
      Potchefstroom, South Africa; MRC Research Unit for Hypertension and 
      Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
FAU - Breet, Yolandi
AU  - Breet Y
AD  - Hypertension in Africa Research Team (HART); North-West University, 
      Potchefstroom, South Africa; MRC Research Unit for Hypertension and 
      Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
FAU - Roux, Shani Botha-le
AU  - Roux SB
AD  - Hypertension in Africa Research Team (HART); North-West University, 
      Potchefstroom, South Africa; MRC Research Unit for Hypertension and 
      Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
FAU - Jacobs, Adriaan
AU  - Jacobs A
AD  - Hypertension in Africa Research Team (HART); North-West University, 
      Potchefstroom, South Africa; MRC Research Unit for Hypertension and 
      Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
FAU - Gafane-Matemane, Lebo F
AU  - Gafane-Matemane LF
AD  - Hypertension in Africa Research Team (HART); North-West University, 
      Potchefstroom, South Africa; MRC Research Unit for Hypertension and 
      Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
FAU - Kruger, Ruan
AU  - Kruger R
AD  - Hypertension in Africa Research Team (HART); North-West University, 
      Potchefstroom, South Africa; MRC Research Unit for Hypertension and 
      Cardiovascular Disease, North-West University, Potchefstroom, South Africa. 
      Electronic address: ruan.kruger@nwu.ac.za.
LA  - eng
GR  - MC_PC_16095/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20220720
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
RN  - 0 (Antioxidants)
RN  - 0 (Lipids)
RN  - 0 (Oxidants)
SB  - IM
CIN - Heart Lung Circ. 2022 Nov;31(11):1427-1428. PMID: 36436839
MH  - Aging
MH  - Antioxidants
MH  - Blood Pressure/physiology
MH  - Humans
MH  - Lipids
MH  - Oxidants
MH  - *Pulse Wave Analysis
MH  - Risk Factors
MH  - *Vascular Stiffness/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Early vascular ageing
OT  - Lifestyle risk factors
OT  - Oxidative stress
OT  - Pulse wave velocity
EDAT- 2022/07/23 06:00
MHDA- 2022/09/28 06:00
CRDT- 2022/07/22 22:05
PHST- 2022/01/10 00:00 [received]
PHST- 2022/05/02 00:00 [revised]
PHST- 2022/05/12 00:00 [accepted]
PHST- 2022/07/23 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/07/22 22:05 [entrez]
AID - S1443-9506(22)00270-0 [pii]
AID - 10.1016/j.hlc.2022.05.042 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2022 Oct;31(10):1376-1384. doi: 10.1016/j.hlc.2022.05.042. Epub 
      2022 Jul 20.