PMID- 35869340 OWN - NLM STAT- MEDLINE DCOM- 20221215 LR - 20221215 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 29 IP - 60 DP - 2022 Dec TI - The association between essential trace element mixture and atherosclerotic cardiovascular disease risk among Chinese community-dwelling older adults. PG - 90351-90363 LID - 10.1007/s11356-022-22066-0 [doi] AB - The evidence about the association of the essential trace element (ETE) mixture with atherosclerotic cardiovascular disease (ASCVD) amongst older adults is limited. This study aims to evaluate the associations of single ETEs and the ETE mixture with the 10-year ASCVD risks and its predicting factors in Chinese community-dwelling older adults. A total of 607 community-dwelling older adults were included in this study. Blood levels of vanadium (V), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), and selenium (Se) were assessed by inductively coupled plasma mass spectrometry. The predicted 10-year ASCVD risk was calculated using the Prediction for ASCVD Risk in China (China-PAR) equations. Traditional linear regressions and Bayesian kernel machine regression (BKMR) were used to assess the associations of single ETEs and the ETE mixture with the 10-year ASCVD risks and its predicting factors such as systolic blood pressure (SBP), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), diabetes, and waist circumference (WC). In linear regression models, blood Cr levels were negatively associated with the 10-year ASCVD risks after adjustment for covariates (beta = - 0.07, 95% CI = - 0.11 ~ - 0.03); The 3th quartile (Q3) of Se levels was also associated with a lower 10-year ASCVD risks when compared with the lowest quartile (Q1) of Se levels (beta(Q3) vs. (Q1): - 0.12, 95% CI = - 0.22 ~ - 0.02). In BKMR models, the negative associations of Cr and Se with the 10-year ASCVD risks were observed. Higher blood levels of ETE mixture were associated with decreased 10-year ASCVD risks in a dose-response pattern, with Cr having the highest value of the posterior inclusion probability (PIP) within the mixture. Furthermore, a positive association between Cr and HDL-C and a negative association between Se and SBP were found in both linear regression and BKMR models. Cr and Se were negatively associated with the 10-year ASCVD risks, individually and as a mixture. ETE mixture showed a linear dose-response association with decreased 10-year ASCVD risks, with Cr being the most important component within the mixture. The negative association of the ETE mixture with the 10-year ASCVD risks may be attributed to Cr and Se, mainly mediated by HDL-C and SBP, respectively. Further cohort studies are needed to clarify this association. CI - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Meng, Xiang-Long AU - Meng XL AD - School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. FAU - Wang, Yuan AU - Wang Y AD - School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. FAU - Wang, Hong-Li AU - Wang HL AD - School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. FAU - Nie, Huan-Huan AU - Nie HH AD - School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. FAU - Cheng, Bei-Jing AU - Cheng BJ AD - School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. FAU - Cao, Hong-Juan AU - Cao HJ AD - Lu'an Municipal Center for Disease Control and Prevention, Lu'an, 237008, Anhui, China. FAU - Li, Xiu-de AU - Li XD AD - School of Public Health, Department of Nutrition and Food Hygiene, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Wang, Su-Fang AU - Wang SF AD - School of Public Health, Department of Nutrition and Food Hygiene, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Chen, Gui-Mei AU - Chen GM AD - School of Health Services Management, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Tao, Fang-Biao AU - Tao FB AD - MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Sheng, Jie AU - Sheng J AD - MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Yang, Lin-Sheng AU - Yang LS AD - School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China. yanglinsheng@ahmu.edu.cn. LA - eng GR - 2016YFC1305900/Key Technology Research and Development Program of Shandong/ GR - 0303011224/Innovative Team and Outstanding Talent Program of Colleges and Universities in Guangxi/ GR - KJ2017A189/the Key Scientific Research Fund of Anhui Provincial Education Department/ GR - Xj201525/Grants for Scientific Research of BSKY from Anhui Medical University/ PT - Journal Article DEP - 20220722 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Trace Elements) RN - 97C5T2UQ7J (Cholesterol) SB - IM MH - Humans MH - Aged MH - *Trace Elements MH - Independent Living MH - Bayes Theorem MH - *Cardiovascular Diseases MH - East Asian People MH - Cholesterol OTO - NOTNLM OT - Atherosclerotic cardiovascular disease OT - Bayesian kernel machine regression OT - Essential trace element mixture OT - Older adults OT - The China-PAR Equations EDAT- 2022/07/23 06:00 MHDA- 2022/12/15 06:00 CRDT- 2022/07/22 23:34 PHST- 2022/04/06 00:00 [received] PHST- 2022/07/13 00:00 [accepted] PHST- 2022/07/23 06:00 [pubmed] PHST- 2022/12/15 06:00 [medline] PHST- 2022/07/22 23:34 [entrez] AID - 10.1007/s11356-022-22066-0 [pii] AID - 10.1007/s11356-022-22066-0 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2022 Dec;29(60):90351-90363. doi: 10.1007/s11356-022-22066-0. Epub 2022 Jul 22.