PMID- 35871156
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20220929
IS  - 1477-2566 (Electronic)
IS  - 1465-3249 (Linking)
VI  - 24
IP  - 10
DP  - 2022 Oct
TI  - A comprehensive human leukocyte antigen analysis of 36 782 cord blood units 
      stored in the Australian Public Cord Blood Banking Network.
PG  - 990-998
LID - S1465-3249(22)00682-X [pii]
LID - 10.1016/j.jcyt.2022.06.002 [doi]
AB  - BACKGROUND AND AIMS: The network of public cord blood banks (CBBs) in Australia, 
      known as AusCord, comprises CBBs located in Brisbane, Sydney and Melbourne. A 
      novel comprehensive analysis has been performed to determine whether the 
      cryopreserved, searchable cord blood unit (CBU) inventory of approximately 36 000 
      units share similar tissue types or haplotypes. METHODS: Human leukocyte antigen 
      (HLA) data was analysed using Microsoft Excel following standardisation of typing 
      data. RESULTS: The analysis has found that the majority of stored, searched and 
      released CBU exhibit a tissue type that is unique within and between the CBBs. 
      Therefore, each collection performed by the CBBs is likely to comprise a tissue 
      type that is not already stored among the total AusCord inventory. HLA alleles 
      (HLA-A*34, HLA-B*56, HLA-DRB1*08:03), which are uncommon in European populations, 
      were associated with Pacific Islander and/or Indigenous Australian populations 
      and confirmed to be more frequent among donors who, when screened, 
      self-identified as these ethnicities. CONCLUSIONS: These data indicate that (i) 
      continued addition of CBU to existing inventories is likely to further increase 
      the HLA diversity and (ii) screening donors for ethnicity or strategically 
      locating collection sites where ethnic minorities reside can successfully result 
      in collection of rare HLA associated with ethnic minority groups for whom finding 
      donors might otherwise be more difficult.
CI  - Copyright (c) 2022 International Society for Cell & Gene Therapy. Published by 
      Elsevier Inc. All rights reserved.
FAU - Klamer, Guy
AU  - Klamer G
AD  - Sydney Cord Blood Bank, Sydney Children's Hospital, Randwick, NSW, Australia; 
      School of Women's and Children's Health, Faculty of Medicine, University of New 
      South Wales, Randwick, NSW, Australia. Electronic address: 
      Guy.Klamer@health.nsw.gov.au.
FAU - Sue, Jessica
AU  - Sue J
AD  - Sydney Cord Blood Bank, Sydney Children's Hospital, Randwick, NSW, Australia.
FAU - Trickett, Annette
AU  - Trickett A
AD  - Bone Marrow Transplant Laboratory, Randwick Hospitals, NSW Health Pathology, 
      Randwick, NSW, Australia.
FAU - Ko, Kap-Hyoun
AU  - Ko KH
AD  - Sydney Cord Blood Bank, Sydney Children's Hospital, Randwick, NSW, Australia.
FAU - Johnson, Phillip
AU  - Johnson P
AD  - Queensland Cord Blood Bank at the Mater, Mater Hospital, Raymond Terrace, 
      Queensland, Australia.
FAU - Elwood, Ngaire J
AU  - Elwood NJ
AD  - BMDI Cord Blood Bank, Murdoch Children's Research Institute, Royal Children's 
      Hospital, Parkville, Victoria, Australia; Department of Paediatrics, University 
      of Melbourne, Parkville, Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220721
PL  - England
TA  - Cytotherapy
JT  - Cytotherapy
JID - 100895309
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Australia
MH  - *Blood Banks
MH  - Ethnicity
MH  - *Fetal Blood
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Minority Groups
OTO - NOTNLM
OT  - Cord blood banking
OT  - Tissue type
OT  - Transplantation
COIS- Declaration of Competing Interest The authors have no commercial, proprietary or 
      financial interest in the products or companies described in this article.
EDAT- 2022/07/24 06:00
MHDA- 2022/09/14 06:00
CRDT- 2022/07/23 23:48
PHST- 2022/02/21 00:00 [received]
PHST- 2022/05/30 00:00 [revised]
PHST- 2022/06/05 00:00 [accepted]
PHST- 2022/07/24 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/07/23 23:48 [entrez]
AID - S1465-3249(22)00682-X [pii]
AID - 10.1016/j.jcyt.2022.06.002 [doi]
PST - ppublish
SO  - Cytotherapy. 2022 Oct;24(10):990-998. doi: 10.1016/j.jcyt.2022.06.002. Epub 2022 
      Jul 21.