PMID- 35871643
OWN - NLM
STAT- MEDLINE
DCOM- 20220726
LR  - 20221207
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Jul 24
TI  - Surgical outcomes associated with sleep apnea syndrome in Stanford A aortic 
      dissection patients.
PG  - 329
LID - 10.1186/s12872-022-02775-7 [doi]
LID - 329
AB  - BACKGROUND: Patients suffering from aortic dissection (AD) often experience sleep 
      apnea syndrome (SAS), which aggravates their respiratory function and aortic 
      false lumen expansion. METHODS: We analyzed the peri-operative data of Stanford A 
      AD patients, with or without SAS, between January 2017 and June 2019. Subjects 
      were separated into SAS positive (SAS(+)) and SAS negative (SAS(-)) cohorts, 
      based on the Apnea-Hypopnea Index (AHI) and the Oxygen Desaturation Index (ODI). 
      We next analyzed variables between the SAS(+) and SAS(-) groups. RESULTS: 155, 
      out of 198 AAD patients, were enlisted for this study. SAS(+) patients exhibited 
      higher rates of pneumonia (p < 0.001), heart failure (HF, p = 0.038), acute 
      kidney injury (AKI, p = 0.001), ventilation time (p = 0.009), and hospitalization 
      duration (p < 0.001). According to subsequent follow-ups, the unstented aorta 
      false lumen dilatation (FLD) rate increased markedly, with increasing degree of 
      SAS (p < 0.001, according to AHI and ODI). The SAS(+) patients exhibited worse 
      cumulative survival rate (p = 0.025). The significant risk factors (RF) for poor 
      survival were: severe (p = 0.002) or moderate SAS (p = 0.008), prolonged 
      ventilation time (p = 0.018), AKI (p = 0.015), HF New York Heart Association 
      (NYHA) IV (p = 0.005) or III (p = 0.015), pneumonia (p = 0.005), Marfan syndrome 
      (p = 0.010), systolic blood pressure (BP) upon arrival (p = 0.009), and BMI >/= 30 
      (p = 0.004). CONCLUSIONS: SAS(+) Stanford A AD patients primarily exhibited 
      higher rates of complications and low survival rates in the mid-time follow-up. 
      Hence, the RFs associated with poor survival must be monitored carefully in SAS 
      patients. Moreover, the FLD rate is related to the degree of SAS, thus treating 
      SAS may mitigate FLD.
CI  - (c) 2022. The Author(s).
FAU - Luo, Zeng-Rong
AU  - Luo ZR
AD  - Department of Cardiovascular Surgery and Cardiac Disease Center, Union Hospital, 
      Fujian Medical University, Fuzhou, 350001, P. R. China.
AD  - Key Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fujian 
      Province University, Fuzhou, P. R. China.
FAU - Yu, Ling-Li
AU  - Yu LL
AD  - Department of Cardiovascular Surgery and Cardiac Disease Center, Union Hospital, 
      Fujian Medical University, Fuzhou, 350001, P. R. China.
AD  - Key Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fujian 
      Province University, Fuzhou, P. R. China.
FAU - Chen, Liang-Wan
AU  - Chen LW
AD  - Department of Cardiovascular Surgery and Cardiac Disease Center, Union Hospital, 
      Fujian Medical University, Fuzhou, 350001, P. R. China. chenliangwan0782@163.com.
AD  - Key Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fujian 
      Province University, Fuzhou, P. R. China. chenliangwan0782@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220724
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Acute Kidney Injury
MH  - *Aortic Dissection/complications/diagnostic imaging/surgery
MH  - Blood Pressure
MH  - Humans
MH  - Oxygen
MH  - *Sleep Apnea Syndromes
MH  - Treatment Outcome
PMC - PMC9310499
OTO - NOTNLM
OT  - Dilatation
OT  - Follow-up
OT  - Sleep apnea syndrome
OT  - Stanford A aortic dissection
OT  - Survival rate
COIS- All authors declare that they have no competing interests.
EDAT- 2022/07/25 06:00
MHDA- 2022/07/27 06:00
PMCR- 2022/07/24
CRDT- 2022/07/24 23:14
PHST- 2022/02/16 00:00 [received]
PHST- 2022/07/19 00:00 [accepted]
PHST- 2022/07/24 23:14 [entrez]
PHST- 2022/07/25 06:00 [pubmed]
PHST- 2022/07/27 06:00 [medline]
PHST- 2022/07/24 00:00 [pmc-release]
AID - 10.1186/s12872-022-02775-7 [pii]
AID - 2775 [pii]
AID - 10.1186/s12872-022-02775-7 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2022 Jul 24;22(1):329. doi: 10.1186/s12872-022-02775-7.