PMID- 35872243
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20221210
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 129
IP  - 6
DP  - 2022 Dec
TI  - Relationship between low serum immunoglobulin E levels and malignancies in 9/11 
      World Trade Center responders.
PG  - 769-775
LID - S1081-1206(22)00598-1 [pii]
LID - 10.1016/j.anai.2022.07.012 [doi]
AB  - BACKGROUND: Individuals with very low immunoglobulin E (IgE) levels have a high 
      risk of developing malignancy. Previous studies have revealed that World Trade 
      Center (WTC) responders exposed to carcinogens have an elevated risk of some 
      cancers. OBJECTIVE: To evaluate the association between low-serum IgE levels and 
      cancer development in WTC-exposed responders. METHODS: IgE levels were measured 
      in 1851 WTC responders after September 11, 2001. This is the first pilot study in 
      humans comparing the odds of developing cancer in this high-risk population, 
      between the "low-IgE" (IgE in the lowest third percentile) vs "non-low-IgE" 
      participants. RESULTS: A significantly higher proportion of hematologic 
      malignancies was found in low-IgE (4/55, 7.3%) compared with non-low-IgE 
      (26/1796, 1.5%, P < .01) responders. The proportion of solid tumors were similar 
      in both groups (5.5% vs 11.4%, P > .05). After adjustment for relevant 
      confounders (race, sex, age at blood draw, WTC arrival time, smoking status), the 
      low-IgE participants had 7.81 times greater odds (95% confidence interval, 
      1.77-29.35) of developing hematologic cancer when compared with non-low-IgE 
      participants. The hematologic cancers found in this cohort were leukemia (n = 1), 
      multiple myeloma (n = 1), and lymphoma (n = 2). No statistical significance was 
      found when estimating the odds ratio for solid tumors in relation to IgE levels. 
      CONCLUSION: WTC responders with low serum IgE levels had the highest odds of 
      developing hematologic malignancies. This hypothesis-generating study suggests 
      that low serum IgE levels might be associated with the development of specific 
      malignancies in at-risk individuals exposed to carcinogens. Larger, multicenter 
      studies with adequate follow-up of individuals with different IgE levels are 
      needed to better evaluate this relationship.
CI  - Copyright (c) 2022 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Ferastraoaru, Denisa
AU  - Ferastraoaru D
AD  - Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York. 
      Electronic address: dferastr@montefiore.org.
FAU - Zeig-Owens, Rachel
AU  - Zeig-Owens R
AD  - Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York; 
      Fire Department of the City of New York (FDNY), Brooklyn, New York.
FAU - Goldfarb, David G
AU  - Goldfarb DG
AD  - Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York; 
      Fire Department of the City of New York (FDNY), Brooklyn, New York.
FAU - Mueller, Alexandra K
AU  - Mueller AK
AD  - Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York; 
      Fire Department of the City of New York (FDNY), Brooklyn, New York.
FAU - Hall, Charles B
AU  - Hall CB
AD  - Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.
FAU - Weiden, Michael D
AU  - Weiden MD
AD  - Fire Department of the City of New York (FDNY), Brooklyn, New York; New York 
      University Grossman School of Medicine, New York, New York.
FAU - Schwartz, Theresa
AU  - Schwartz T
AD  - Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York; 
      Fire Department of the City of New York (FDNY), Brooklyn, New York.
FAU - Prezant, David J
AU  - Prezant DJ
AD  - Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York; 
      Fire Department of the City of New York (FDNY), Brooklyn, New York.
FAU - Rosenstreich, David
AU  - Rosenstreich D
AD  - Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220721
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Carcinogens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Ann Allergy Asthma Immunol. 2022 Dec;129(6):663-664. PMID: 36464394
MH  - Humans
MH  - *September 11 Terrorist Attacks
MH  - Pilot Projects
MH  - *Neoplasms/epidemiology
MH  - Carcinogens
MH  - *Hematologic Neoplasms/epidemiology
MH  - Immunoglobulin E
MH  - New York City/epidemiology
EDAT- 2022/07/26 06:00
MHDA- 2022/12/07 06:00
CRDT- 2022/07/25 01:53
PHST- 2022/05/18 00:00 [received]
PHST- 2022/06/21 00:00 [revised]
PHST- 2022/07/11 00:00 [accepted]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/07/25 01:53 [entrez]
AID - S1081-1206(22)00598-1 [pii]
AID - 10.1016/j.anai.2022.07.012 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2022 Dec;129(6):769-775. doi: 
      10.1016/j.anai.2022.07.012. Epub 2022 Jul 21.