PMID- 35872985
OWN - NLM
STAT- MEDLINE
DCOM- 20220726
LR  - 20220730
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone 
      Fracture.
PG  - 918350
LID - 10.3389/fendo.2022.918350 [doi]
LID - 918350
AB  - Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporosis. The effects of 
      T2DM and anti-diabetic agents on bone and mineral metabolism have been observed. 
      Sodium-glucose co-transporter 2 inhibitors (SGLT-2is) promote urinary glucose 
      excretion, reduce blood glucose level, and improve the cardiovascular and 
      diabetic nephropathy outcomes. In this review, we focused on the extraglycemic 
      effect and physiological regulation of SGLT-2is on bone and mineral metabolism. 
      SGLT-2is affect the bone turnover, microarchitecture, and bone strength 
      indirectly. Clinical evidence of a meta-analysis showed that SGLT-2is might not 
      increase the risk of bone fracture. The effect of SGLT-2is on bone fracture is 
      controversial, and further investigation from a real-world study is needed. Based 
      on its significant benefit on cardiovascular and chronic kidney disease (CKD) 
      outcomes, SGLT-2is are an outstanding choice. Bone mineral density (BMD) and 
      fracture risk evaluation should be considered for patients with a high risk of 
      bone fracture.
CI  - Copyright (c) 2022 Dong, Lv, Wang, Che, Wang, Huai, Wang and Xu.
FAU - Dong, Bingzi
AU  - Dong B
AD  - Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
FAU - Lv, Ruolin
AU  - Lv R
AD  - Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
FAU - Wang, Jun
AU  - Wang J
AD  - Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
FAU - Che, Lin
AU  - Che L
AD  - Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Wang, Zhongchao
AU  - Wang Z
AD  - Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
FAU - Huai, Zhouyang
AU  - Huai Z
AD  - Department of Geriatric Medicine, Yantai Yuhuangding Hospital Affiliated Hospital 
      of Qingdao University, Yantai, China.
FAU - Wang, Yangang
AU  - Wang Y
AD  - Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
FAU - Xu, Lili
AU  - Xu L
AD  - Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220707
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Minerals)
RN  - 0 (Sodium-Glucose Transporter 2 Inhibitors)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - *Fractures, Bone/etiology/prevention & control
MH  - Glucose
MH  - Humans
MH  - Minerals
MH  - *Sodium-Glucose Transporter 2 Inhibitors/pharmacology/therapeutic use
PMC - PMC9302585
OTO - NOTNLM
OT  - bone and mineral metabolism
OT  - bone fracture risk
OT  - bone turnover
OT  - sodium-glucose cotransporter-2 inhibitor
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/26 06:00
MHDA- 2022/07/27 06:00
PMCR- 2022/01/01
CRDT- 2022/07/25 03:28
PHST- 2022/04/12 00:00 [received]
PHST- 2022/05/30 00:00 [accepted]
PHST- 2022/07/25 03:28 [entrez]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/07/27 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.918350 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jul 7;13:918350. doi: 
      10.3389/fendo.2022.918350. eCollection 2022.