PMID- 35873566
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220726
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 13
DP  - 2022
TI  - Characterization of Lactate Metabolism Score in Breast and Thyroid Cancers to 
      Assist Immunotherapy via Large-Scale Transcriptomic Data Analysis.
PG  - 928419
LID - 10.3389/fphar.2022.928419 [doi]
LID - 928419
AB  - Breast cancer (BC) and thyroid cancer (TC) have the highest rate of incidence, 
      especially in women. Previous studies have revealed that lactate provides 
      energetic and anabolic support to cancer cells, thus serving as an important 
      oncometabolite with both extracellular and intracellular signaling functions. 
      However, the correlation of lactate metabolism scores with thyroid and breast 
      cancer immune characteristics remains to be systematically analyzed. To 
      investigate the role of lactate at the transcriptome level and its correlation 
      with the clinical outcome of BC and TC, transcriptome data of 1,217 patients with 
      breast cancer (BC) and 568 patients with thyroid cancer (TC) were collected from 
      The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets with 
      their corresponding clinical and somatic mutation data. The lactate metabolism 
      score was calculated based on a single-sample gene set enrichment analysis 
      (ssGSEA). The results showed that lactate metabolism-related genes and lactate 
      metabolism scores was significantly associated with the survival of patients with 
      BRCA and THCA. Notably, the lactate metabolism scores were strongly correlated 
      with human leukocyte antigen (HLA) expression, tumor-infiltrating lymphocyte 
      (TIL) infiltration, and interferon (IFN) response in BC and TC. Furthermore, the 
      lactate metabolism score was an independent prognostic factor and could serve as 
      a reliable predictor of overall survival, clinical characteristics, and immune 
      cell infiltration, with the potential to be applied in immunotherapy or precise 
      chemotherapy of BC and TC.
CI  - Copyright (c) 2022 Wang, Qu, Chen, Pan, Tang, Hu, Gao, Niu, Liu, Gao and Fang.
FAU - Wang, Cheng
AU  - Wang C
AD  - Department of Breast Surgery, Huangpu Branch, Shanghai Ninth People's Hospital, 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Qu, Zheng
AU  - Qu Z
AD  - Department of Breast Surgical Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, China.
FAU - Chen, Li
AU  - Chen L
AD  - Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College 
      of Huazhong University of Science and Technology, Wuhan, China.
FAU - Pan, Yunhao
AU  - Pan Y
AD  - Department of Breast Surgery, Huangpu Branch, Shanghai Ninth People's Hospital, 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Tang, Yiqing
AU  - Tang Y
AD  - Department of Breast Surgery, Huangpu Branch, Shanghai Ninth People's Hospital, 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Hu, Guangfu
AU  - Hu G
AD  - Department of Breast Surgery, Huangpu Branch, Shanghai Ninth People's Hospital, 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Gao, Ran
AU  - Gao R
AD  - Department of Breast Surgical Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, China.
FAU - Niu, Ruijie
AU  - Niu R
AD  - Department of Breast Surgery, Huangpu Branch, Shanghai Ninth People's Hospital, 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Liu, Qiang
AU  - Liu Q
AD  - Department of Breast Surgical Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, China.
FAU - Gao, Xingyan
AU  - Gao X
AD  - Department of Breast Surgery, Huangpu Branch, Shanghai Ninth People's Hospital, 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Fang, Yi
AU  - Fang Y
AD  - Department of Breast Surgical Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220707
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC9301074
OTO - NOTNLM
OT  - breast cancer
OT  - cancer immunotherapy
OT  - immune infiltrates
OT  - lactate metabolism score
OT  - prognostic factor
OT  - thyroid cancer
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/26 06:00
MHDA- 2022/07/26 06:01
PMCR- 2022/07/07
CRDT- 2022/07/25 03:37
PHST- 2022/04/25 00:00 [received]
PHST- 2022/06/16 00:00 [accepted]
PHST- 2022/07/25 03:37 [entrez]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/07/26 06:01 [medline]
PHST- 2022/07/07 00:00 [pmc-release]
AID - 928419 [pii]
AID - 10.3389/fphar.2022.928419 [doi]
PST - epublish
SO  - Front Pharmacol. 2022 Jul 7;13:928419. doi: 10.3389/fphar.2022.928419. 
      eCollection 2022.