PMID- 35874897
OWN - NLM
STAT- MEDLINE
DCOM- 20220726
LR  - 20220726
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2022
DP  - 2022
TI  - Methylated RNA Immunoprecipitation Sequencing Reveals the m(6)A Landscape in Oral 
      Squamous Cell Carcinoma.
PG  - 7277583
LID - 10.1155/2022/7277583 [doi]
LID - 7277583
AB  - N6-methyladenosine (m(6)A) is the most common epigenetic modification existing in 
      eukaryocyte transcripts. However, genes related to m(6)A modification in oral 
      squamous cell carcinoma (OSCC) are still unclear. Here, methylated RNA 
      immunoprecipitation sequencing (MeRIP-Seq) was performed to map the m6A landscape 
      in OSCC and corresponding controls. The m(6)A peaks are always distributed in the 
      junction of the 3'-untranslated regions (3'-UTRs) and the coding sequences (CDS) 
      of mRNAs, as well as the entire genome of long noncoding RNA (lncRNA). 
      Furthermore, enrichment analysis showed that differentially methylated genes were 
      significantly enriched in NF-kappa B signaling pathway, Hedgehog signaling 
      pathway, etc. In summary, our findings reveal the landscape of m(6)A modification 
      on mRNAs and lncRNAs in OSCC, which may provide key clues for the 
      precision-targeted therapy of OSCC.
CI  - Copyright (c) 2022 Xi Wang et al.
FAU - Wang, Xi
AU  - Wang X
AD  - The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 
      300070, China.
FAU - Wu, Jie
AU  - Wu J
AD  - The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 
      300070, China.
FAU - Zhang, Leyu
AU  - Zhang L
AD  - The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 
      300070, China.
FAU - Zhao, Wei
AU  - Zhao W
AUID- ORCID: 0000-0002-3153-3817
AD  - The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 
      300070, China.
FAU - Deng, Jiayin
AU  - Deng J
AUID- ORCID: 0000-0002-1856-6032
AD  - The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 
      300070, China.
LA  - eng
PT  - Journal Article
DEP - 20220715
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - 3' Untranslated Regions
MH  - *Carcinoma, Squamous Cell/genetics/metabolism
MH  - *Head and Neck Neoplasms/genetics
MH  - Hedgehog Proteins/genetics
MH  - Humans
MH  - Immunoprecipitation
MH  - *Mouth Neoplasms/genetics/metabolism
MH  - *RNA, Long Noncoding/genetics/metabolism
MH  - RNA, Messenger/genetics
MH  - Squamous Cell Carcinoma of Head and Neck/genetics
PMC - PMC9307381
COIS- The authors declare that they have no competing interests.
EDAT- 2022/07/26 06:00
MHDA- 2022/07/27 06:00
PMCR- 2022/07/15
CRDT- 2022/07/25 04:00
PHST- 2022/04/13 00:00 [received]
PHST- 2022/05/27 00:00 [accepted]
PHST- 2022/07/25 04:00 [entrez]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/07/27 06:00 [medline]
PHST- 2022/07/15 00:00 [pmc-release]
AID - 10.1155/2022/7277583 [doi]
PST - epublish
SO  - J Immunol Res. 2022 Jul 15;2022:7277583. doi: 10.1155/2022/7277583. eCollection 
      2022.