PMID- 35875660
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220726
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 15
DP  - 2022
TI  - Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile 
      Stimuli.
PG  - 901466
LID - 10.3389/fnmol.2022.901466 [doi]
LID - 901466
AB  - Nociceptors in the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are 
      necessary for transmitting pain and itch signals. However, the molecular 
      mechanism regulating nociceptor development remains largely unknown. This study 
      identifies that the transcription factor Meis1 is generally expressed in two 
      groups of sensory neurons in the developing DRG. During prenatal and neonatal 
      stages, approximately 2/3 of Meis1+ neurons are Runx1+ nociceptors, while 1/3 of 
      Meis1+ neurons are NF200+ myelinated neurons. At postnatal stages, Meis1 
      expression in nociceptors is gradually reduced. Here, we constructed a Meis1 
      conditional knockout mouse line to selectively delete Meis1 in Nav1.8 lineage 
      nociceptors. Microarray analyses showed that differentially expressed genes in 
      the Meis1 mutant DRG were enriched in pathways related to sensory perception of 
      pain and nervous system development. In addition, Meis1 regulates the expression 
      of some marker genes of Nppb+ neurons and C-LTMRs. Furthermore, Meis1 mutant mice 
      exhibit behavioral deficits in response to light mechanical pain, static touch 
      and chemical itch. Therefore, this study reveals that Meis1 is required to 
      regulate the development of nociceptors.
CI  - Copyright (c) 2022 Cao, Huang, Lu, Jiang, Hu, Cao and Liu.
FAU - Cao, Zheng
AU  - Cao Z
AD  - Beijing Institute of Biotechnology, Beijing, China.
AD  - School of Biological Engineering and Food Science, Hubei University of 
      Technology, Wuhan, China.
FAU - Huang, Chengcheng
AU  - Huang C
AD  - Beijing Institute of Biotechnology, Beijing, China.
AD  - General Hospital of Central Theater Command, Wuhan, China.
FAU - Lu, Fumin
AU  - Lu F
AD  - Beijing Institute of Biotechnology, Beijing, China.
FAU - Jiang, Xuequan
AU  - Jiang X
AD  - Beijing Institute of Biotechnology, Beijing, China.
AD  - School of Biological Engineering and Food Science, Hubei University of 
      Technology, Wuhan, China.
FAU - Hu, Yong
AU  - Hu Y
AD  - Beijing Institute of Biotechnology, Beijing, China.
FAU - Cao, Cheng
AU  - Cao C
AD  - Beijing Institute of Biotechnology, Beijing, China.
FAU - Liu, Zijing
AU  - Liu Z
AD  - Beijing Institute of Biotechnology, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220706
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC9301487
OTO - NOTNLM
OT  - C-LTMR
OT  - Meis1
OT  - itch
OT  - microarray
OT  - nociceptor
OT  - pain
OT  - touch
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/26 06:00
MHDA- 2022/07/26 06:01
PMCR- 2022/01/01
CRDT- 2022/07/25 04:13
PHST- 2022/03/22 00:00 [received]
PHST- 2022/06/13 00:00 [accepted]
PHST- 2022/07/25 04:13 [entrez]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/07/26 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2022.901466 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2022 Jul 6;15:901466. doi: 10.3389/fnmol.2022.901466. 
      eCollection 2022.