PMID- 35875993
OWN - NLM
STAT- MEDLINE
DCOM- 20230424
LR  - 20230424
IS  - 1478-6427 (Electronic)
IS  - 1478-6419 (Linking)
VI  - 37
IP  - 10
DP  - 2023 May
TI  - Systematic characterisation of the effective components of five Callicarpa 
      species with UPLC-Q-TOF-MS and evaluation of their anti-hyperuricaemic activity.
PG  - 1662-1667
LID - 10.1080/14786419.2022.2102628 [doi]
AB  - Callicarpa kwangtungensis (C. Kw), C. macrophylla (C. Ma), C. nudiflora (C. Nu), 
      C. formosana (C. Fo), and C. kochiana (C. Ko) were medicinal plant resource in 
      China. In this study, the UPLC/Q-TOF-MS analysis was performed and 151 compounds 
      were identified. PCA analysis metabolic profiles of C. Nu, C. Ko and C. Kw leaves 
      differ significantly from the other two Callicarpa species, while C. Fo and C. Ma 
      share similar chemical constituents. OPLS-DA highlight with an S-plot indicated 
      that there are 14 robust known chemical markers enabling the differentiation 
      between these five Callicarpa plants. C. Ma, C. Nu, and C. Fo leaves extracts 
      treatment effectively reversed the body weight loss, uric acid and creatinine 
      content, hepatic XOD activity, kidney, liver, and ankle tissues injury and 
      inflammation induced by potassium oxonate in hyperuricemia mice. While Ko and C. 
      Kw leaves extracts treatment showed less improvement in hyperuricemia mice.
FAU - Feng, Shixiu
AU  - Feng S
AD  - Fairylake Botanical Garden, Shenzhen & Chinese Academy of Sciences, Key 
      Laboratory of South Subtropical Plant Diversity, Shenzhen, China.
FAU - Wang, Luolin
AU  - Wang L
AD  - Department of gastroenterology, Shenzhen People's Hospital, (The Second Clinical 
      Medical College, Jinan University; The First Affiliated Hospital, Southern 
      University of Science and Technology), Shenzhen, China.
FAU - Deng, Li
AU  - Deng L
AD  - Fairylake Botanical Garden, Shenzhen & Chinese Academy of Sciences, Key 
      Laboratory of South Subtropical Plant Diversity, Shenzhen, China.
FAU - Zhang, Min
AU  - Zhang M
AD  - Fairylake Botanical Garden, Shenzhen & Chinese Academy of Sciences, Key 
      Laboratory of South Subtropical Plant Diversity, Shenzhen, China.
FAU - Ma, Wenyu
AU  - Ma W
AD  - Fairylake Botanical Garden, Shenzhen & Chinese Academy of Sciences, Key 
      Laboratory of South Subtropical Plant Diversity, Shenzhen, China.
FAU - Liang, Xiangping
AU  - Liang X
AD  - College of life sciences, Qinghai Normal University, Xining, China.
FAU - Xie, Huichun
AU  - Xie H
AD  - College of life sciences, Qinghai Normal University, Xining, China.
FAU - Yi, Bo
AU  - Yi B
AD  - Department of Pharmacy, the 928th Hospital of PLA Joint Logistics Support Force, 
      Haikou, China.
LA  - eng
PT  - Journal Article
DEP - 20220723
PL  - England
TA  - Nat Prod Res
JT  - Natural product research
JID - 101167924
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Callicarpa/chemistry
MH  - *Hyperuricemia/drug therapy
MH  - Inflammation
MH  - Metabolome
MH  - *Plants, Medicinal/chemistry
MH  - Chromatography, High Pressure Liquid
MH  - Mass Spectrometry
OTO - NOTNLM
OT  - Callicarpa
OT  - OPLS-DA
OT  - PCA
OT  - UPLC/Q-TOF-MS
OT  - hyperuricaemia
EDAT- 2022/07/26 06:00
MHDA- 2023/04/20 06:42
CRDT- 2022/07/25 04:53
PHST- 2023/04/20 06:42 [medline]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/07/25 04:53 [entrez]
AID - 10.1080/14786419.2022.2102628 [doi]
PST - ppublish
SO  - Nat Prod Res. 2023 May;37(10):1662-1667. doi: 10.1080/14786419.2022.2102628. Epub 
      2022 Jul 23.