PMID- 35876123
OWN - NLM
STAT- MEDLINE
DCOM- 20230807
LR  - 20230807
IS  - 1536-7290 (Electronic)
IS  - 1536-7290 (Linking)
VI  - 23
IP  - 8
DP  - 2023 Aug
TI  - Circulating sestrins and force velocity profiling in older adults with type 2 
      diabetes.
PG  - 1710-1719
LID - 10.1080/17461391.2022.2106158 [doi]
AB  - Type 2 diabetes mellitus (T2DM) in old age affects the musculoskeletal system 
      causing loss of muscle mass, strength, and physical function. Stress-inducible 
      proteins named sestrins are potential novel biomarkers of muscle function due to 
      their ability to suppress oxidative stress and prevent muscle degeneration. Our 
      aim was to determine the association between different force-velocity (F-V) 
      profiles with body composition, physical performance, and glucose control in 
      older adults with T2DM. We also intended to determine the potential utility of 
      sestrin 1 (Sesn1) and 2 (Sesn2) as biomarkers of physical functionality. 
      Fifty-nine participants (69-79 years) were classified in 3 groups according to 
      their F-V profile based on the leg press exercise: nondeficit (N(DEF )= 40.7%), 
      force deficit (F(DEF )= 28.8%), and velocity deficit (V(DEF )= 30.5%). Both 
      V(DEF) and F(DEF) groups showed lower muscle power than N(DEF) (Cohen's d 0.87 
      and 0.75 for effect size, respectively). Serum Sesn2 levels, maximal dynamic 
      strength, arms and legs fat-free mass were reduced in F(DEF) compared to the 
      N(DEF) group (p < 0.05), whereas glycated haemoglobin (HbA1c) and fasting glucose 
      levels were similar among groups. ROC analysis revealed the distinction between 
      the N(DEF) and F(DEF) group based on Sesn2 concentrations (<0.72 ng/mL), 
      suggesting their potential use as functional biomarkers for early intervention 
      through exercise. Older adults with T2DM show different F-V profiles, related to 
      low levels of Sesn2, impaired body composition and physical performance, and may 
      be taken into consideration to target exercise training in this specific 
      population.Highlights The influence of different F-V deficit profiles on body 
      composition, physical function and circulating sestrins in older adults with type 
      2 diabetes were studied.Both force and velocity deficits negatively affected 
      muscle power.Force deficits are associated to low circulating sestrin 2 levels 
      and regional fat-free mass.Basal serum sestrin 2 levels are potential biomarkers 
      to characterise F-V profiles.
FAU - Gonzalez-Martos, Raquel
AU  - Gonzalez-Martos R
AUID- ORCID: 0000-0003-3340-1794
AD  - ImFINE Research Group, Department of Health and Human Performance, Universidad 
      Politecnica de Madrid, Madrid, Spain.
AD  - Cancer Stem Cell Research Group, Department of Biotechnology-Vegetal Biology, 
      Centro de Tecnologia Biomedica, Universidad Politecnica de Madrid, Madrid, Spain.
AD  - GENUD Toledo Research Group, Universidad Castilla-La Mancha, Toledo, Spain.
FAU - Aparicio-Ugarriza, Raquel
AU  - Aparicio-Ugarriza R
AUID- ORCID: 0000-0001-7342-5972
AD  - ImFINE Research Group, Department of Health and Human Performance, Universidad 
      Politecnica de Madrid, Madrid, Spain.
AD  - CIBER of Biomedical Research Networking Center on Physiopathology of Obesity and 
      Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
FAU - Alcazar, Julian
AU  - Alcazar J
AUID- ORCID: 0000-0002-1090-5482
AD  - GENUD Toledo Research Group, Universidad Castilla-La Mancha, Toledo, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 
      ISCIII, Madrid, Spain.
FAU - Ramirez-Castillejo, Carmen
AU  - Ramirez-Castillejo C
AUID- ORCID: 0000-0002-1877-3381
AD  - Cancer Stem Cell Research Group, Department of Biotechnology-Vegetal Biology, 
      Centro de Tecnologia Biomedica, Universidad Politecnica de Madrid, Madrid, Spain.
FAU - Reihmane, Dace
AU  - Reihmane D
AUID- ORCID: 0000-0003-4929-4436
AD  - Department of Human Physiology and Biochemistry, Riga Stradins University, Riga, 
      Latvia.
FAU - Menendez-Rey, Adrian
AU  - Menendez-Rey A
AUID- ORCID: 0000-0003-0326-6392
AD  - Cancer Stem Cell Research Group, Department of Biotechnology-Vegetal Biology, 
      Centro de Tecnologia Biomedica, Universidad Politecnica de Madrid, Madrid, Spain.
FAU - Gonzalez-Gross, Marcela
AU  - Gonzalez-Gross M
AUID- ORCID: 0000-0001-7757-3235
AD  - ImFINE Research Group, Department of Health and Human Performance, Universidad 
      Politecnica de Madrid, Madrid, Spain.
AD  - CIBER of Biomedical Research Networking Center on Physiopathology of Obesity and 
      Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
FAU - Guadalupe-Grau, Amelia
AU  - Guadalupe-Grau A
AUID- ORCID: 0000-0003-2573-4572
AD  - ImFINE Research Group, Department of Health and Human Performance, Universidad 
      Politecnica de Madrid, Madrid, Spain.
AD  - GENUD Toledo Research Group, Universidad Castilla-La Mancha, Toledo, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 
      ISCIII, Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20220819
PL  - Germany
TA  - Eur J Sport Sci
JT  - European journal of sport science
JID - 101146739
RN  - 0 (Sestrins)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Sestrins
MH  - *Diabetes Mellitus, Type 2
MH  - Muscle, Skeletal/physiology
MH  - Body Composition
MH  - Biomarkers
MH  - Muscle Strength/physiology
OTO - NOTNLM
OT  - Performance
OT  - aging
OT  - biochemistry
OT  - body composition
OT  - musculoskeletal
EDAT- 2022/07/26 06:00
MHDA- 2023/08/07 06:42
CRDT- 2022/07/25 05:54
PHST- 2023/08/07 06:42 [medline]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/07/25 05:54 [entrez]
AID - 10.1080/17461391.2022.2106158 [doi]
PST - ppublish
SO  - Eur J Sport Sci. 2023 Aug;23(8):1710-1719. doi: 10.1080/17461391.2022.2106158. 
      Epub 2022 Aug 19.