PMID- 35876136
OWN - NLM
STAT- MEDLINE
DCOM- 20220812
LR  - 20220925
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 10
IP  - 31
DP  - 2022 Aug 10
TI  - Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease.
PG  - 5853-5872
LID - 10.1039/d2tb01190e [doi]
AB  - As a group of chronic and idiopathic gastrointestinal (GI) disorders, 
      inflammatory bowel disease (IBD) is characterized by recurrent intestinal mucosal 
      inflammation. Oral administration is critical for the treatment of IBD. 
      Unfortunately, it is difficult to target the bowel located in the GI tract due to 
      multiple physical barriers. The unique physicochemical properties of 
      nanoparticle-based drug delivery systems (DDSs) and their enhanced permeability 
      and retention effects in the inflamed bowel, render nanomedicines to be used to 
      implement precise drug delivery at diseased sites in IBD therapy. In this review, 
      we described the pathophysiological features of IBD, and designed strategies to 
      exploit these features for intestinal targeting. In addition, we introduced the 
      types of currently developed nano-targeted carriers, including synthetic 
      nanoparticle-based and emerging naturally derived nanoparticles (e.g., 
      extracellular vesicles and plant-derived nanoparticles). Moreover, recent 
      developments in targeted oral nanoparticles for IBD therapy were also 
      highlighted. Finally, we presented challenges associated with nanotechnology and 
      potential directions for future IBD treatment.
FAU - Li, De-Feng
AU  - Li DF
AD  - Department of Gastroenterology, Shenzhen People's Hospital (the Second Clinical 
      Medical College, Jinan University, the First Affiliated Hospital, Southern 
      University of Science and Technology), No. 1017, Dongmen North Road, Luohu 
      District, Shenzhen 518020, Guangdong, China. yao.jun@szhospital.com.
FAU - Yang, Mei-Feng
AU  - Yang MF
AD  - Department of Hematology, Yantian District People's Hospital, Shenzhen 518020, 
      Guangdong, China.
FAU - Xu, Hao-Ming
AU  - Xu HM
AD  - Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease 
      Center, Guangzhou First People's Hospital, School of Medicine, South China 
      University of Technology, Guangzhou 510030, China.
FAU - Zhu, Min-Zheng
AU  - Zhu MZ
AUID- ORCID: 0000-0002-1986-6520
AD  - Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease 
      Center, Guangzhou First People's Hospital, School of Medicine, South China 
      University of Technology, Guangzhou 510030, China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Department of Medical Administration, Huizhou Institute of Occupational Diseases 
      Control and Prevention, Huizhou 516000, Guangdong, China.
FAU - Tian, Cheng-Mei
AU  - Tian CM
AD  - Department of Emergency, Shenzhen People's Hospital (the Second Clinical Medical 
      College, Jinan University, the First Affiliated Hospital, Southern University of 
      Science and Technology), Shenzhen 518020, Guangdong, China.
FAU - Nie, Yu-Qiang
AU  - Nie YQ
AD  - Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease 
      Center, Guangzhou First People's Hospital, School of Medicine, South China 
      University of Technology, Guangzhou 510030, China.
FAU - Wang, Jian-Yao
AU  - Wang JY
AD  - Department of General Surgery, Shenzhen Children's Hospital, No. 7019, Yitian 
      Road, Futian District, Shenzhen 518026, Guangdong, China. yaozi_66@126.com.
FAU - Liang, Yu-Jie
AU  - Liang YJ
AUID- ORCID: 0000-0002-0860-4859
AD  - Shenzhen Kangning Hospital, No. 1080, Cuizu Road, Luohu District, Shenzhen 
      518020, Guangdong, China. liangyjie@126.com.
FAU - Yao, Jun
AU  - Yao J
AD  - Department of Gastroenterology, Shenzhen People's Hospital (the Second Clinical 
      Medical College, Jinan University, the First Affiliated Hospital, Southern 
      University of Science and Technology), No. 1017, Dongmen North Road, Luohu 
      District, Shenzhen 518020, Guangdong, China. yao.jun@szhospital.com.
FAU - Wang, Li-Sheng
AU  - Wang LS
AUID- ORCID: 0000-0001-5965-308X
AD  - Department of Gastroenterology, Shenzhen People's Hospital (the Second Clinical 
      Medical College, Jinan University, the First Affiliated Hospital, Southern 
      University of Science and Technology), No. 1017, Dongmen North Road, Luohu 
      District, Shenzhen 518020, Guangdong, China. yao.jun@szhospital.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220810
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
MH  - Administration, Oral
MH  - Drug Delivery Systems
MH  - Humans
MH  - *Inflammatory Bowel Diseases/drug therapy
MH  - Nanomedicine
MH  - *Nanoparticles
EDAT- 2022/07/26 06:00
MHDA- 2022/08/13 06:00
CRDT- 2022/07/25 06:03
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/08/13 06:00 [medline]
PHST- 2022/07/25 06:03 [entrez]
AID - 10.1039/d2tb01190e [doi]
PST - epublish
SO  - J Mater Chem B. 2022 Aug 10;10(31):5853-5872. doi: 10.1039/d2tb01190e.