PMID- 35876150
OWN - NLM
STAT- MEDLINE
DCOM- 20221021
LR  - 20230302
IS  - 1535-3699 (Electronic)
IS  - 1535-3702 (Print)
IS  - 1535-3699 (Linking)
VI  - 247
IP  - 18
DP  - 2022 Sep
TI  - hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in 
      type 2 diabetes mellitus.
PG  - 1609-1618
LID - 10.1177/15353702221110648 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a multifactorial disorder that leads to 
      alterations in gene regulation. ncRNAs have the characteristics of tissue 
      specificity, disease specificity, timing specificity, high stability and post 
      transcriptional regulation effect. These preconditions are more conducive to 
      promote ncRNA to become a new biomarker for clinical diagnosis. Our study aims to 
      explore the relationship between circRNA, lncRNA, miRNA and T2DM, and to evaluate 
      their diagnostic value for T2DM. A total of 101 pairs of T2DM and controls were 
      conducted in the study. QRT-PCR was used to study the differential expression of 
      circRNAs, miRNAs and lncRNAs. ROC curve was used to estimate their diagnostic 
      value in T2DM. Compared with healthy controls, the expression levels of 
      hsa_circ_0071106, hsa_circ_0000284, hsa_circ_0071271, hsa-miR-29a-5p, 
      hsa-miR-3690, hsa-miR-607, lncRNA MEG3 and lncRNA TUG1were higher in T2DM (all 
      P < 0.05). The AUCs of hsa_circ_0071106, hsa-miR-607 and lncRNA TUG1 for 
      diagnosis of T2DM were 0.563,0.645 and 0.642, respectively. The combined AUC of 
      hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 was 0.798 ([0.720~0.875], 
      P < 0.001). Moreover, the sensitivity of combined diagnosis was 75.2% and the 
      specificity was 100.0%. The levels of lncRNA TUG1, hsa-miR-607 and 
      hsa_circ_0071106 in peripheral blood have potential clinical diagnostic value for 
      T2DM.
FAU - Su, Manna
AU  - Su M
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, 
      China.
FAU - Yu, Tongxin
AU  - Yu T
AD  - School of mathematics and Statistics, Shandong University, Weihai 264209, China.
FAU - Yu, Yongji
AU  - Yu Y
AD  - The Second People's Hospital of Huadu District, Guangzhou 510320, China.
FAU - Cheng, Qiuting
AU  - Cheng Q
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, 
      China.
FAU - Zheng, Yingying
AU  - Zheng Y
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, 
      China.
FAU - Liao, Rifang
AU  - Liao R
AD  - Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, 
      Guangzhou 510120, China.
FAU - Zeng, Zhuanping
AU  - Zeng Z
AUID- ORCID: 0000-0002-6893-4876
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220723
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (MIRN607 microRNA, human)
RN  - 0 (RNA, Circular)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (MicroRNAs)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - RNA, Circular/genetics
MH  - *RNA, Long Noncoding/genetics
MH  - *Diabetes Mellitus, Type 2/diagnosis/genetics
MH  - *MicroRNAs/metabolism
MH  - Biomarkers
PMC - PMC9597214
OTO - NOTNLM
OT  - ROC
OT  - T2DM
OT  - circRNA
OT  - lncRNA
OT  - miRNA
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2022/07/26 06:00
MHDA- 2022/10/22 06:00
PMCR- 2023/03/01
CRDT- 2022/07/25 06:12
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/10/22 06:00 [medline]
PHST- 2022/07/25 06:12 [entrez]
PHST- 2023/03/01 00:00 [pmc-release]
AID - 10.1177_15353702221110648 [pii]
AID - 10.1177/15353702221110648 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2022 Sep;247(18):1609-1618. doi: 
      10.1177/15353702221110648. Epub 2022 Jul 23.