PMID- 35876351
OWN - NLM
STAT- MEDLINE
DCOM- 20220805
LR  - 20230830
IS  - 1896-494X (Electronic)
IS  - 1232-1087 (Print)
IS  - 1232-1087 (Linking)
VI  - 35
IP  - 4
DP  - 2022 Aug 1
TI  - Exocrine pancreatic cancer and living near to waste sites containing hazardous 
      organic chemicals, New York State, USA - an 18-year population-based study.
PG  - 459-471
LID - 145794 [pii]
LID - 10.13075/ijomeh.1896.01886 [doi]
AB  - OBJECTIVES: The etiology of exocrine pancreatic cancer (EPC) remains unknown 
      except for family history and smoking. Despite recent medical advances, rates of 
      pancreatic cancer incidence and mortality are increasing. Although existing 
      evidence suggests a potentially causal relationship between environmental 
      chemical exposures and pancreatic cancer, whether residential exposure impacts 
      pancreatic cancer rates remains unknown. MATERIAL AND METHODS: The authors 
      identified 28 941 patients diagnosed with exocrine pancreatic cancer in New York 
      State exclusive of New York City for the years 1996-2013. Descriptive statistics 
      and negative binomial regression were used in this ecological study to compare 
      pancreatic cancer hospitalization rates among patients who lived in zip codes 
      with hazardous waste sites (HWSs) containing persistent organic pollutants (POPs) 
      and volatile organic pollutants (VOCs) compared with clean zip codes with no 
      identified hazardous waste sites. The authors assessed the effect of selected 
      known and suspected human carcinogens on the EPC hospitalization rates by 
      subgroup analyses. RESULTS: Compared with the clean sites, the pancreatic cancer 
      hospital discharge rate in the "VOCs without POPs" and "VOCs and POPs" sites, 
      after adjustment for potential confounders were 1.06 (95% CI: 1.03-1.09) and 1.05 
      (95% CI: 1.01-1.08), respectively. In the analysis by specific chemicals, rate 
      ratios (RR) for the benzene (RR = 1.12) and ethylbenzene (RR = 1.34) in the 
      non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene 
      (RR = 1.11) in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and 
      PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values 
      <0.05) compared with clean sites. CONCLUSIONS: Compared with the clean sites, the 
      pancreatic cancer hospital discharge rate in the "VOCs without POPs" and "VOCs 
      and POPs" sites, after adjustment for potential confounders were 1.06 (95% CI: 
      1.03-1.09) and 1.05 (95% CI: 1.01-1.08), respectively. In the analysis by 
      specific chemicals, rate ratios (RR) for the benzene (RR = 1.12) and ethylbenzene 
      (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and 
      tetrachloroethylene (RR = 1.11) in the chlorinated VOCs group, chlorinated 
      pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically 
      significant (p-values <0.05) compared with clean sites. Int J Occup Med Environ 
      Health. 2022;35(4):459-71.
CI  - This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL 
      license.
FAU - Weinstein, Bayarmagnai
AU  - Weinstein B
AD  - University at Albany, Rensselaer, NY, USA (Department of Environmental Health 
      Sciences, School of Public Health).
FAU - da Silva, Alan
AU  - da Silva A
AD  - University of Brasilia, Brasilia, Brazil (Department of Statistics).
FAU - Carpenter, David O
AU  - Carpenter DO
AD  - University at Albany, Rensselaer, NY, USA (Department of Environmental Health 
      Sciences, School of Public Health).
AD  - University at Albany, Rensselaer, NY, USA (Institute for Health and the 
      Environment).
LA  - eng
PT  - Journal Article
DEP - 20220725
PL  - Poland
TA  - Int J Occup Med Environ Health
JT  - International journal of occupational medicine and environmental health
JID - 9437093
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hazardous Substances)
RN  - 0 (Hazardous Waste)
RN  - 0 (Pesticides)
RN  - 290YE8AR51 (Trichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - J64922108F (Benzene)
RN  - TJ904HH8SN (Tetrachloroethylene)
SB  - IM
MH  - Benzene
MH  - *Environmental Pollutants
MH  - Hazardous Substances
MH  - Hazardous Waste
MH  - Humans
MH  - New York/epidemiology
MH  - *Pancreatic Neoplasms/chemically induced/epidemiology
MH  - *Pesticides
MH  - *Polychlorinated Biphenyls
MH  - *Tetrachloroethylene
MH  - *Trichloroethylene
PMC - PMC10464772
OTO - NOTNLM
OT  - PCBs
OT  - VOCs
OT  - benzene
OT  - pancreatic cancer
OT  - pesticides
OT  - residential exposure
EDAT- 2022/07/26 06:00
MHDA- 2022/08/06 06:00
PMCR- 2022/01/01
CRDT- 2022/07/25 07:53
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/08/06 06:00 [medline]
PHST- 2022/07/25 07:53 [entrez]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 145794 [pii]
AID - ijomeh.1896.01886 [pii]
AID - 10.13075/ijomeh.1896.01886 [doi]
PST - ppublish
SO  - Int J Occup Med Environ Health. 2022 Aug 1;35(4):459-471. doi: 
      10.13075/ijomeh.1896.01886. Epub 2022 Jul 25.