PMID- 35876649
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20221003
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 45
IP  - 9
DP  - 2022 Sep 1
TI  - Twenty-Year Temporal Trends in Risk of Ischemic Stroke in Incident Type 2 
      Diabetes: A Danish Population-Based Cohort Study.
PG  - 2144-2151
LID - 10.2337/dc22-0440 [doi]
AB  - OBJECTIVE: We examined temporal trends in risk of first-time ischemic stroke in 
      patients with incident type 2 diabetes mellitus (T2DM) and no prior 
      atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS: 
      Using nationwide health registries, we identified all patients with incident T2DM 
      without a prior hospital diagnosis of ASCVD from 1996 to 2015 in Denmark. 
      Patients were assigned to 5-year periods based on the date of T2DM diagnosis and 
      were followed for 5 years. Each patient was matched by sex and age with up to 
      three individuals from the general population. Temporal trends in ischemic stroke 
      were examined using Cox regression to compute hazard ratios (HRs). Temporal use 
      of prophylactic cardiovascular medications was also assessed. RESULTS: The study 
      comprised 288,825 patients with incident T2DM and 782,232 general population 
      individuals. From 1996-2000 to 2011-2015, the 5-year risk of first-time ischemic 
      stroke was approximately halved in the T2DM cohort (5.2% vs. 2.7%; sex- and 
      age-adjusted HR 0.52 [95% CI 0.49-0.55]). Patients diagnosed in 2011-2015 had 
      increased risk of ischemic stroke compared with individuals in the general 
      population; however, the risk difference narrowed over time (5.2% vs. 2.9% in 
      1996-1999 [difference 2.3%]; 2.7% vs. 2.0% in 2011-2015 [difference 0.7%]). Use 
      of prophylactic cardiovascular medications increased markedly during the overall 
      study period, especially use of statins (from 5% to 50%) and multiple 
      antihypertensive drugs (from 18% to 33%). CONCLUSIONS: From 1996 to 2015, the 
      5-year risk of first-time ischemic stroke was approximately halved in patients 
      with incident T2DM and no prior ASCVD, coinciding with markedly increased use of 
      prophylactic cardiovascular medications.
CI  - (c) 2022 by the American Diabetes Association.
FAU - Gyldenkerne, Christine
AU  - Gyldenkerne C
AUID- ORCID: 0000-0001-5904-7063
AD  - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
AD  - Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus 
      University Hospital, Aarhus, Denmark.
FAU - Kahlert, Johnny
AU  - Kahlert J
AD  - Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus 
      University Hospital, Aarhus, Denmark.
FAU - Olesen, Kevin K W
AU  - Olesen KKW
AD  - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
AD  - Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus 
      University Hospital, Aarhus, Denmark.
FAU - Thrane, Pernille G
AU  - Thrane PG
AD  - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Sorensen, Henrik T
AU  - Sorensen HT
AD  - Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus 
      University Hospital, Aarhus, Denmark.
FAU - Thomsen, Reimar W
AU  - Thomsen RW
AD  - Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus 
      University Hospital, Aarhus, Denmark.
FAU - Maeng, Michael
AU  - Maeng M
AD  - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
LA  - eng
SI  - figshare/10.2337/figshare.20198651
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Cohort Studies
MH  - Denmark/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Humans
MH  - *Ischemic Stroke
MH  - Risk Factors
MH  - *Stroke/diagnosis/epidemiology/etiology
EDAT- 2022/07/26 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/07/25 09:53
PHST- 2022/03/03 00:00 [received]
PHST- 2022/06/12 00:00 [accepted]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/07/25 09:53 [entrez]
AID - 147286 [pii]
AID - 10.2337/dc22-0440 [doi]
PST - ppublish
SO  - Diabetes Care. 2022 Sep 1;45(9):2144-2151. doi: 10.2337/dc22-0440.