PMID- 35877436
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220728
IS  - 1467-3045 (Electronic)
IS  - 1467-3037 (Print)
IS  - 1467-3037 (Linking)
VI  - 44
IP  - 7
DP  - 2022 Jul 6
TI  - The Expression and Prognostic Significance of VEGF and CXCR4 in Gastric Cancer: 
      Correlation with Angiogenesis, Lymphangiogenesis and Progression.
PG  - 3075-3088
LID - 10.3390/cimb44070212 [doi]
AB  - The cellular response to hypoxia includes the expression of hypoxia-inducible 
      factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) 
      and CXC chemokine receptor 4 (CXCR4). The aim of this study was to investigate 
      the expression and prognostic significance of VEGF and CXCR4, which are 
      responsible for angiogenesis and progression in gastric cancer. Twenty-eight 
      gastric cancer patients were analyzed. The mRNA expression was examined in 
      primary tumors and corresponding normal gastric mucosa by RT-PCR. The protein 
      level was examined by immunohistochemistry staining. The high expression of VEGF 
      and CXCR4 was found in 71.0 and 64.0% of tumors, respectively. The mean levels of 
      VEGF and CXCR4 were upregulated in primary tumors compared to normal mucosa (p = 
      0.0007, p = 0.0052). A correlation between VEGF expression and tumor invasion (p 
      = 0.0216) and stage (p = 0.0181) was found. CXCR4 expression correlated with 
      lymph node metastases (p = 0.0237) and stage (p = 0.0054). The VEGF expression 
      correlated with microvessel density (MVD) (p = 0.0491). The overall 3-year 
      survival rate was 46.4% and correlated negatively with high CXCR4 mRNA expression 
      (p = 0.0089). VEGF and CXCR4 play an important role in tumor progression. Their 
      overexpression correlates with a bad prognosis and may improve high-risk patient 
      selection, and these patients may obtain additional survival benefits if treated 
      more aggressively.
FAU - Kruszyna, Lukasz
AU  - Kruszyna L
AUID- ORCID: 0000-0001-5205-5765
AD  - Department of Vascular and Endovascular Surgery, Angiology and Phlebology, Poznan 
      University of Medical Sciences, Dluga (1/2) St., 61-848 Poznan, Poland.
FAU - Murawa, Dawid
AU  - Murawa D
AD  - Department of General Surgery and Surgical Oncology, Faculty of Medicine and 
      Health Sciences, University of Zielona Gora, Zyty 26 St., 65-046 Zielona Gora, 
      Poland.
FAU - Jagodzinski, Pawel Piotr
AU  - Jagodzinski PP
AUID- ORCID: 0000-0002-9046-6802
AD  - Department of Biochemistry and Molecular Biology, Poznan University of Medical 
      Sciences, Swiecickiego 6 St., 60-781 Poznan, Poland.
FAU - Oszkinis, Grzegorz
AU  - Oszkinis G
AD  - Department of Vascular and General Surgery, Institute of Medical Sciences, 
      University of Opole, Witosa 26 St., 45-401 Opole, Poland.
FAU - Krasinski, Zbigniew
AU  - Krasinski Z
AD  - Department of Vascular and Endovascular Surgery, Angiology and Phlebology, Poznan 
      University of Medical Sciences, Dluga (1/2) St., 61-848 Poznan, Poland.
LA  - eng
GR  - NN403 1696 37/Poland's Ministry of Science and Higher Education/
PT  - Journal Article
DEP - 20220706
PL  - Switzerland
TA  - Curr Issues Mol Biol
JT  - Current issues in molecular biology
JID - 100931761
PMC - PMC9324442
OTO - NOTNLM
OT  - CXCR4
OT  - VEGF
OT  - angiogenesis
OT  - gastric cancer
OT  - lymph node metastases
OT  - lymphangiogenesis
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/26 06:00
MHDA- 2022/07/26 06:01
PMCR- 2022/07/06
CRDT- 2022/07/25 12:44
PHST- 2022/05/31 00:00 [received]
PHST- 2022/06/27 00:00 [revised]
PHST- 2022/07/04 00:00 [accepted]
PHST- 2022/07/25 12:44 [entrez]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/07/26 06:01 [medline]
PHST- 2022/07/06 00:00 [pmc-release]
AID - cimb44070212 [pii]
AID - cimb-44-00212 [pii]
AID - 10.3390/cimb44070212 [doi]
PST - epublish
SO  - Curr Issues Mol Biol. 2022 Jul 6;44(7):3075-3088. doi: 10.3390/cimb44070212.