PMID- 35878584
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221221
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 81
IP  - 6
DP  - 2022
TI  - Association between the Rostral Anterior Cingulate Cortex and Anterior Insula in 
      the Salience Network on Response to Antidepressants in Major Depressive Disorder 
      as Revealed by Isolated Effective Coherence.
PG  - 475-483
LID - 10.1159/000525338 [doi]
AB  - INTRODUCTION: Functional connectivity is attracting increasing attention for 
      understanding the pathophysiology of depression and predicting the therapeutic 
      efficacy of antidepressants. In this study, we evaluated effective connectivity 
      using isolated effective coherence (iCoh), an effective functional connectivity 
      analysis method developed from low-resolution brain electromagnetic tomography 
      (LORETA) and estimated its practical usefulness for predicting the reaction to 
      antidepressants in theta and alpha band iCoh values. METHODS: We enrolled 25 
      participants from a depression treatment randomized study (the GUNDAM study) in 
      which electroencephalography was performed before treatment. We conducted iCoh 
      between the rostral anterior cingulate cortex (rACC) and anterior insula (AI), 
      which are associated with the salience network. The patients were divided into 
      responder and nonresponder groups at 4 weeks after the start of treatment, and 
      iCoh values were compared between the two groups. Additionally, the sensitivity 
      and specificity of iCoh were calculated using the receiver-operating 
      characteristic (ROC) curve. RESULTS: The Mann-Whitney U test showed significantly 
      weaker connectivity flow from the rACC to the left AI in the alpha band in the 
      responder group. The ROC curve for the connectivity flow from the rACC to the 
      left AI in the alpha band showed 82% sensitivity and 86% specificity. 
      DISCUSSION/CONCLUSION: These findings suggest the pathological importance of 
      effective connectivity flow from the rACC to the left AI in the alpha and theta 
      bands and suggest its usefulness as a biomarker to distinguish responders to 
      antidepressants.
CI  - (c) 2022 The Author(s). Published by S. Karger AG, Basel.
FAU - Minami, Shota
AU  - Minami S
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, 
      Moriguchi, Japan.
FAU - Kato, Masaki
AU  - Kato M
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, 
      Moriguchi, Japan.
FAU - Ikeda, Shunichiro
AU  - Ikeda S
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, 
      Moriguchi, Japan.
FAU - Yoshimura, Masafumi
AU  - Yoshimura M
AD  - Department of Occupational Therapy, Faculty of Rehabilitation, Kansai Medical 
      University, Hirakata, Japan.
FAU - Ueda, Satsuki
AU  - Ueda S
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, 
      Moriguchi, Japan.
FAU - Koshikawa, Yosuke
AU  - Koshikawa Y
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, 
      Moriguchi, Japan.
FAU - Takekita, Yoshiteru
AU  - Takekita Y
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, 
      Moriguchi, Japan.
FAU - Kinoshita, Toshihiko
AU  - Kinoshita T
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, 
      Moriguchi, Japan.
FAU - Nishida, Keiichiro
AU  - Nishida K
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, 
      Moriguchi, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220725
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Humans
MH  - *Depressive Disorder, Major/diagnostic imaging/drug therapy
MH  - Gyrus Cinguli/diagnostic imaging
MH  - Theta Rhythm
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - Electroencephalography
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - Anterior insula
OT  - Antidepressants
OT  - Isolated effective coherence
OT  - Major depression
OT  - Rostral anterior cingulate cortex
EDAT- 2022/07/26 06:00
MHDA- 2022/12/17 06:00
CRDT- 2022/07/25 18:27
PHST- 2022/02/17 00:00 [received]
PHST- 2022/05/12 00:00 [accepted]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/12/17 06:00 [medline]
PHST- 2022/07/25 18:27 [entrez]
AID - 000525338 [pii]
AID - 10.1159/000525338 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2022;81(6):475-483. doi: 10.1159/000525338. Epub 2022 Jul 25.