PMID- 35879632
OWN - NLM
STAT- MEDLINE
DCOM- 20221215
LR  - 20221215
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 60
DP  - 2022 Dec
TI  - Acute and sublethal effects of acrylamide on the freshwater fish Anabas 
      testudineus (Bloch, 1792).
PG  - 90835-90851
LID - 10.1007/s11356-022-22155-0 [doi]
AB  - Acrylamide, a synthetic compound, has a wide range of industrial applications 
      that find multiple ways to reach aquatic ecosystem. The median lethal 
      concentration of acrylamide determined using probit analysis in the fish Anabas 
      testudineus was 132 microg L(-1) concentration together with altered behavioral 
      patterns. Hematological and antioxidant status was evaluated at a sublethal 
      concentration (one-tenth of LC(50)-96 h), i.e., 13.2 microg L(-1) concentration for 
      24, 48, 72, and 96 h. A reduction in erythrocytes count, hemoglobin content, and 
      packed cell volume with a significant (P < 0.05) increase in leukocyte counts and 
      differential counts were observed. Erythrocyte indices like mean corpuscular 
      volume (MCV) and mean corpuscular hemoglobin (MCH) increased, whereas the mean 
      corpuscular hemoglobin concentration (MCHC) showed a significant (P < 0.05) 
      decrease when compared with control groups. The activities of superoxide 
      dismutase, catalase, and glutathione reductase in gill tissues showed significant 
      (P < 0.05) reduction, whereas the levels of hydrogen peroxide and lipid 
      peroxidation increased significantly (P < 0.05) indicating oxidative stress. The 
      findings suggest that acrylamide at sublethal concentration caused alteration in 
      hematological parameters and induced oxidative stress in gill tissue of the fish 
      A. testudineus. Hence, restrictions on the use of acrylamide in food and 
      industrial products are recommended since humans are the direct consumer of fish 
      products.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Ligina, Velliyath
AU  - Ligina V
AD  - Endocrinology and Toxicology Laboratory, Department of Zoology, University of 
      Calicut, Malappuram District, Kerala, 673 635, India.
FAU - Martin, Ranjana
AU  - Martin R
AD  - Endocrinology and Toxicology Laboratory, Department of Zoology, University of 
      Calicut, Malappuram District, Kerala, 673 635, India.
FAU - Aiswarya, Moolamkottil Venugopalan
AU  - Aiswarya MV
AD  - Endocrinology and Toxicology Laboratory, Department of Zoology, University of 
      Calicut, Malappuram District, Kerala, 673 635, India.
FAU - Mashirin, Kajahussain Reeha
AU  - Mashirin KR
AD  - Endocrinology and Toxicology Laboratory, Department of Zoology, University of 
      Calicut, Malappuram District, Kerala, 673 635, India.
FAU - Chitra, Kumari Chidambaran
AU  - Chitra KC
AUID- ORCID: 0000-0002-5090-8709
AD  - Endocrinology and Toxicology Laboratory, Department of Zoology, University of 
      Calicut, Malappuram District, Kerala, 673 635, India. kcchitra@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20220725
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 20R035KLCI (Acrylamide)
SB  - IM
MH  - Humans
MH  - *Acrylamide/toxicity
MH  - *Ecosystem
OTO - NOTNLM
OT  - Acrylamide
OT  - Acute toxicity
OT  - Anabas testudineus
OT  - Behavior
OT  - Hematology
OT  - Oxidative stress
OT  - Sublethal effects
EDAT- 2022/07/26 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/07/25 23:40
PHST- 2021/11/23 00:00 [received]
PHST- 2022/07/19 00:00 [accepted]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/07/25 23:40 [entrez]
AID - 10.1007/s11356-022-22155-0 [pii]
AID - 10.1007/s11356-022-22155-0 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Dec;29(60):90835-90851. doi: 
      10.1007/s11356-022-22155-0. Epub 2022 Jul 25.